FGF23 signaling impairs neutrophil recruitment and host defense during CKD.

PubWeight™: 1.57‹?› | Rank: Top 4%

🔗 View Article (PMID 26878171)

Published in J Clin Invest on February 15, 2016

Authors

Jan Rossaint, Jessica Oehmichen, Hugo Van Aken, Stefan Reuter, Hermann J Pavenstädt, Melanie Meersch, Mark Unruh, Alexander Zarbock

Articles citing this

Fibroblast Growth Factor 23 and Cause-Specific Mortality in the General Population: The Northern Manhattan Study. J Clin Endocrinol Metab (2016) 0.82

Management of secondary hyperparathyroidism: how and why? Clin Exp Nephrol (2017) 0.79

Clinical features of CKD-MBD in Japan: cohort studies and registry. Clin Exp Nephrol (2016) 0.78

Extrarenal effects of FGF23. Pediatr Nephrol (2016) 0.78

Fibroblast Growth Factor 23 Levels Associate with AKI and Death in Critical Illness. J Am Soc Nephrol (2016) 0.77

Multiple faces of fibroblast growth factor-23. Curr Opin Nephrol Hypertens (2016) 0.75

Cardiac actions of fibroblast growth factor 23. Bone (2016) 0.75

Inflammation and elevated levels of fibroblast growth factor 23 are independent risk factors for death in chronic kidney disease. Kidney Int (2016) 0.75

Is Fibroblast growth factor 23 the leading cause of increased mortality among chronic kidney disease patients? A narrative review. J Adv Res (2017) 0.75

Pathways and Genes Associated with Immune Dysfunction in Sheep Paratuberculosis. Sci Rep (2017) 0.75

The systemic nature of CKD. Nat Rev Nephrol (2017) 0.75

Fibroblast Growth Factor 23 and the Risk of Infection-Related Hospitalization in Older Adults. J Am Soc Nephrol (2016) 0.75

Blockade of PLD2 Ameliorates Intestinal Mucosal Inflammation of Inflammatory Bowel Disease. Mediators Inflamm (2016) 0.75

Fibroblast Growth Factor-23-A Potential Uremic Toxin. Toxins (Basel) (2016) 0.75

FGF23 in kidney transplant: the strange case of Doctor Jekyll and Mister Hyde. Clin Kidney J (2016) 0.75

Inflammation regulates fibroblast growth factor 23 production. Curr Opin Nephrol Hypertens (2016) 0.75

Ironing out the cross talk between FGF23 and inflammation. Am J Physiol Renal Physiol (2016) 0.75

Chronic kidney disease: FGF-23 inhibits neutrophil activation. Nat Rev Nephrol (2016) 0.75

Calcineurin inhibitors regulate fibroblast growth factor 23 (FGF23) synthesis. Naunyn Schmiedebergs Arch Pharmacol (2017) 0.75

Articles cited by this

Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol (2007) 17.18

Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev (2005) 9.62

Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature (2006) 9.40

Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med (2008) 9.19

Structural basis of integrin regulation and signaling. Annu Rev Immunol (2007) 8.60

FGF23 induces left ventricular hypertrophy. J Clin Invest (2011) 7.22

Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci U S A (2001) 6.70

Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem (2006) 6.50

Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease. JAMA (2011) 5.86

Chronic kidney disease. Lancet (2011) 5.42

Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease. Kidney Int (2011) 4.74

Anti-inflammatory cytokines. Chest (2000) 4.74

Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol (2006) 3.68

The neutrophil in vascular inflammation. Nat Med (2011) 2.84

The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss. Nat Immunol (2012) 2.48

Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1. Immunity (2007) 2.43

FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality. J Clin Invest (2012) 2.41

PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop. Am J Physiol Renal Physiol (2010) 2.19

Circulating fibroblast growth factor 23 in patients with end-stage renal disease treated by peritoneal dialysis is intact and biologically active. J Clin Endocrinol Metab (2009) 2.12

GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med (2011) 2.01

2-(2-Fluorobenzamido)benzoate ethyl ester (EFB-1) inhibits superoxide production by human neutrophils and attenuates hemorrhagic shock-induced organ dysfunction in rats. Free Radic Biol Med (2011) 1.89

Update on fibroblast growth factor 23 in chronic kidney disease. Kidney Int (2012) 1.82

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling. J Exp Med (2008) 1.79

Oxidative stress in uremia: nature, mechanisms, and potential consequences. Semin Nephrol (2004) 1.65

Endothelial dysfunction, inflammation and atherosclerosis in chronic kidney disease--a cross-sectional study of predialysis, dialysis and kidney-transplantation patients. Atherosclerosis (2011) 1.63

Chronic kidney disease worsens sepsis and sepsis-induced acute kidney injury by releasing High Mobility Group Box Protein-1. Kidney Int (2011) 1.52

Acute loss of renal function attenuates slow leukocyte rolling and transmigration by interfering with intracellular signaling. Kidney Int (2011) 1.51

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways. Blood (2010) 1.40

Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils. Blood (2010) 1.37

Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy. Cell Metab (2015) 1.27

Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo. J Exp Med (2011) 1.25

Arrest chemokines. Microcirculation (2003) 1.21

Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling. Eur J Immunol (2011) 1.19

Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytes. J Bone Miner Res (2013) 1.17

Galphai2 is required for chemokine-induced neutrophil arrest. Blood (2007) 1.16

VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis. J Cell Sci (2009) 1.13

Regulation of lymphocyte adhesion and migration by the small GTPase Rap1 and its effector molecule, RAPL. Immunol Lett (2004) 1.13

Cause of Death in Patients with Reduced Kidney Function. J Am Soc Nephrol (2015) 1.11

The influence of uraemia and haemodialysis on neutrophil phagocytosis and antimicrobial killing. Nephrol Dial Transplant (2003) 1.10

Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med (2012) 1.07

LAD-III, a leukocyte adhesion deficiency syndrome associated with defective Rap1 activation and impaired stabilization of integrin bonds. Blood (2003) 1.06

Progression of kidney disease: blocking leukocyte recruitment with chemokine receptor CCR1 antagonists. Kidney Int (2006) 1.00

Leukocyte integrin activation and deactivation: novel mechanisms of balancing inflammation. J Mol Med (Berl) (2011) 0.99

Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung. J Exp Med (2012) 0.99

Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling. Blood (2013) 0.99

Annexin A1 counteracts chemokine-induced arterial myeloid cell recruitment. Circ Res (2014) 0.97

In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines. J Exp Med (2014) 0.93

The PSGL-1-L-selectin signaling complex regulates neutrophil adhesion under flow. J Exp Med (2013) 0.93

Low Vitamin D and High Fibroblast Growth Factor 23 Serum Levels Associate with Infectious and Cardiac Deaths in the HEMO Study. J Am Soc Nephrol (2015) 0.90

Cardiac myocyte-derived follistatin-like 1 prevents renal injury in a subtotal nephrectomy model. J Am Soc Nephrol (2014) 0.90

Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone. J Biol Chem (2011) 0.90

GDF-15 prevents platelet integrin activation and thrombus formation. J Thromb Haemost (2013) 0.89

Uremia suppresses immune signal-induced CYP27B1 expression in human monocytes. Am J Nephrol (2012) 0.87

The AGC kinase inhibitor H89 attenuates airway inflammation in mouse models of asthma. PLoS One (2012) 0.82

Characterization of FGF receptor expression in human neutrophils and their contribution to chemotaxis. Am J Physiol Cell Physiol (2011) 0.81

Mutation in the CD45 inhibitory wedge modulates integrin activation and leukocyte recruitment during inflammation. J Immunol (2014) 0.80

Sinomenine protects against lipopolysaccharide-induced acute lung injury in mice via adenosine A(2A) receptor signaling. PLoS One (2013) 0.80

Associations of FGF23 With Change in Bone Mineral Density and Fracture Risk in Older Individuals. J Bone Miner Res (2015) 0.77

Articles by these authors

FGF23 induces left ventricular hypertrophy. J Clin Invest (2011) 7.22

Hydroxyethyl starches: different products--different effects. Anesthesiology (2009) 3.23

Effect of waxy maize-derived hydroxyethyl starch 130/0.4 on renal function in surgical patients. Anesthesiology (2013) 3.13

Rates and risk factors for nonadherence to the medical regimen after adult solid organ transplantation. Transplantation (2007) 2.49

Effects of combined arginine vasopressin and levosimendan on organ function in ovine septic shock. Crit Care Med (2010) 2.22

Considerations in the statistical analysis of hemodialysis patient survival. J Am Soc Nephrol (2009) 2.18

Terlipressin dose response in healthy and endotoxemic sheep: impact on cardiopulmonary performance and global oxygen transport. Intensive Care Med (2002) 2.17

Assessment of hemodynamic efficacy and safety of 6% hydroxyethylstarch 130/0.4 vs. 0.9% NaCl fluid replacement in patients with severe sepsis: the CRYSTMAS study. Crit Care (2012) 2.07

GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med (2011) 2.01

Parenteral L-alanyl-L-glutamine improves 6-month outcome in critically ill patients. Crit Care Med (2002) 1.96

Heart rate variability (HRV) in kidney failure: measurement and consequences of reduced HRV. Nephrol Dial Transplant (2007) 1.91

The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via nuclear factor kappaB and mitogen-activated protein kinase pathways. J Exp Med (2002) 1.85

Meta-analysis of risk for relapse to substance use after transplantation of the liver or other solid organs. Liver Transpl (2008) 1.83

Alveolar macrophage activation is a key initiation signal for acute lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol (2006) 1.80

Synchronized integrin engagement and chemokine activation is crucial in neutrophil extracellular trap-mediated sterile inflammation. Blood (2013) 1.80

Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice. Arterioscler Thromb Vasc Biol (2008) 1.76

Prospective clinical evaluation of a LightCycler-mediated polymerase chain reaction assay, a nested-PCR assay and a galactomannan enzyme-linked immunosorbent assay for detection of invasive aspergillosis in neutropenic cancer patients and haematological stem cell transplant recipients. Br J Haematol (2004) 1.73

Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability. EMBO J (2011) 1.69

Role of selective V1a receptor agonism in ovine septic shock. Crit Care Med (2011) 1.68

Incidence of spinal haematoma after epidural puncture: analysis from the German network for safety in regional anaesthesia. Eur J Anaesthesiol (2012) 1.66

Early clinical experiences with the new influenza A (H1N1/09). Dtsch Arztebl Int (2009) 1.65

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood (2012) 1.64

Management of pulmonary hypertension: physiological and pharmacological considerations for anesthesiologists. Anesth Analg (2003) 1.60

Quality of life of living kidney donors in Germany: a survey with the Validated Short Form-36 and Giessen Subjective Complaints List-24 questionnaires. Transplantation (2004) 1.59

High phosphate directly affects endothelial function by downregulating annexin II. Kidney Int (2012) 1.57

Single-lung ventilation for pulmonary lobe resection in a newborn. Anesth Analg (2005) 1.55

Meta-analysis of medical regimen adherence outcomes in pediatric solid organ transplantation. Transplantation (2009) 1.54

Acute loss of renal function attenuates slow leukocyte rolling and transmigration by interfering with intracellular signaling. Kidney Int (2011) 1.51

The soluble VEGF receptor sFlt1 contributes to endothelial dysfunction in CKD. J Am Soc Nephrol (2009) 1.50

Reversible cardiac sympathectomy by high thoracic epidural anesthesia improves regional left ventricular function in patients undergoing coronary artery bypass grafting: a randomized trial. Arch Surg (2003) 1.50

Therapeutic administration of thoracic epidural anesthesia reduces cardiopulmonary deterioration in ovine pulmonary embolism. Crit Care Med (2007) 1.49

Coordinated and unique functions of the E-selectin ligand ESL-1 during inflammatory and hematopoietic recruitment in mice. Blood (2013) 1.49

Inhaled nitric oxide reduces lung edema during fluid resuscitation in ovine acute lung injury. Intensive Care Med (2003) 1.47

Effects of balanced crystalloid vs. 0.9% saline-based vs. balanced 6% tetrastarch infusion on renal function and tubular integrity in ovine endotoxemic shock. Crit Care Med (2011) 1.46

Early multiple organ failure after recurrent endotoxemia in the presence of vasoconstrictor-masked hypovolemia. Crit Care Med (2003) 1.46

Delayed onset of malignant hyperthermia in desflurane anesthesia. Anesth Analg (2003) 1.44

IL-17A inhibits the expansion of IL-17A-producing T cells in mice through "short-loop" inhibition via IL-17 receptor. J Immunol (2008) 1.41

A tribute to Dr. Paul A. J. Janssen: entrepreneur extraordinaire, innovative scientist, and significant contributor to anesthesiology. Anesth Analg (2008) 1.41

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways. Blood (2010) 1.40

Intensive care medicine: a multidisciplinary approach! Eur J Anaesthesiol (2011) 1.40

Argon: neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury. Crit Care (2009) 1.40

Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity. Mol Cell Biol (2007) 1.38

Regional anaesthesia and antithrombotic agents: recommendations of the European Society of Anaesthesiology. Eur J Anaesthesiol (2010) 1.37

Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils. Blood (2010) 1.37

Influenza vaccine delivery and effectiveness in end-stage renal disease. Kidney Int (2003) 1.36

IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice. J Immunol (2007) 1.35

Evolution of raltegravir resistance during therapy. J Antimicrob Chemother (2009) 1.33

Postoperative analgesia after knee surgery: a comparison of three different concentrations of ropivacaine for continuous femoral nerve blockade. Anesth Analg (2007) 1.32

von Willebrand factor promotes leukocyte extravasation. Blood (2010) 1.31

Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation. J Exp Med (2008) 1.27

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo. J Exp Med (2011) 1.27

12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis. J Immunol (2009) 1.27

Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study. Crit Care (2010) 1.26

Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13). J Biol Chem (2008) 1.26

Adherence to the medical regimen during the first two years after lung transplantation. Transplantation (2008) 1.26

Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo. J Exp Med (2011) 1.25

Re-evaluating currently available data and suggestions for planning randomised controlled studies regarding the use of hydroxyethyl starch in critically ill patients - a multidisciplinary statement. Crit Care (2013) 1.24

Integrin Regulation during Leukocyte Recruitment. J Immunol (2013) 1.24

Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study. Crit Care (2009) 1.20

Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling. Eur J Immunol (2011) 1.19

Individual quality of life in chronic kidney disease: influence of age and dialysis modality. Clin J Am Soc Nephrol (2009) 1.18

Fatigue in patients receiving maintenance dialysis: a review of definitions, measures, and contributing factors. Am J Kidney Dis (2008) 1.18

Urinary biomarkers and renal recovery in critically ill patients with renal support. Clin J Am Soc Nephrol (2011) 1.17

Treatment of invasive fungal infections in cancer patients--recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol (2008) 1.17

Infrequent dialysis: a new paradigm for hemodialysis initiation. Semin Dial (2013) 1.16

Close relationship between clinical regression and specific serology in the follow-up of patients with alveolar echinococcosis in different clinical stages. Am J Trop Med Hyg (2009) 1.16

CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis. Blood (2010) 1.16

Effect of the interleukin-6 promoter polymorphism (-174 G/C) on the incidence and outcome of sepsis. Crit Care Med (2002) 1.16

Arginine vasopressin compromises gut mucosal microcirculation in septic rats. Crit Care Med (2004) 1.13

Acute uremia but not renal inflammation attenuates aseptic acute lung injury: a critical role for uremic neutrophils. J Am Soc Nephrol (2006) 1.12

Hepatic infestation of Echinococcus multilocularis with extension to regional lymph nodes. Langenbecks Arch Surg (2009) 1.12

Nicotinamide increases systemic vascular resistance in ovine endotoxemia. Intensive Care Med (2003) 1.12

Health related quality of life in patients with chronic kidney disease. Int Urol Nephrol (2005) 1.12

Nasotracheal intubation: a simple and effective technique to reduce nasopharyngeal trauma and tube contamination. Anesth Analg (2002) 1.09

Heme-induced heme oxygenase-1 (HO-1) in human monocytes inhibits apoptosis despite caspase-3 up-regulation. Int Immunol (2004) 1.07

Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med (2012) 1.07

More attention to respiration: a simple but effective approach to reduce postoperative mortality? Anesthesiology (2015) 1.07

Nocturia, sleep-disordered breathing, and cardiovascular morbidity in a community-based cohort. PLoS One (2012) 1.07

Comorbid conditions in kidney transplantation: association with graft and patient survival. J Am Soc Nephrol (2005) 1.06

Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury. Crit Care (2012) 1.05

Phenylephrine versus norepinephrine for initial hemodynamic support of patients with septic shock: a randomized, controlled trial. Crit Care (2008) 1.04

Impact of fatigue on outcomes in the hemodialysis (HEMO) study. Am J Nephrol (2011) 1.03

Adam17-dependent shedding limits early neutrophil influx but does not alter early monocyte recruitment to inflammatory sites. Blood (2011) 1.03

Role of arginine vasopressin and terlipressin as first-line vasopressor agents in fulminant ovine septic shock. Intensive Care Med (2009) 1.02

Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration. Am J Respir Crit Care Med (2007) 1.01

CXCR2: From Bench to Bedside. Front Immunol (2012) 1.01

Thrombospondin-1 mediates platelet adhesion at high shear via glycoprotein Ib (GPIb): an alternative/backup mechanism to von Willebrand factor. FASEB J (2003) 1.01

Long-term experience on surgical treatment of alveolar echinococcosis. Langenbecks Arch Surg (2008) 1.01

Calculation of direct antiretroviral treatment costs and potential cost savings by using generics in the German HIV ClinSurv cohort. PLoS One (2011) 1.00

Role of selective V2-receptor-antagonism in septic shock: a randomized, controlled, experimental study. Crit Care (2010) 1.00

Hazardous situation in the MR bore: induction in ECG leads causes fire. Eur Radiol (2003) 0.99