Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 26933761)

Published in Int J Cancer on March 25, 2016

Authors

Dominique Harnicek1, Eric Kampmann2, Kirsten Lauber3, Roman Hennel3, Ana Sofia Cardoso Martins1, Yang Guo4, Claus Belka3, Simone Mörtl5, Eike Gallmeier6, Roland Kanaar7,8, Ulrich Mansmann9, Tomas Hucl10, Lars H Lindner2, Wolfgang Hiddemann2, Rolf D Issels2

Author Affiliations

1: Hämatologikum of the Helmholtz Center Munich, German Research Center for Environmental Health, Munich, Germany.
2: Department of Medicine III, University Hospital Grosshadern, University of Munich, Munich, Germany.
3: Department of Radiation Oncology, University Hospital Grosshadern, University of Munich, Munich, Germany.
4: Department of Medicine II, University Hospital Grosshadern, University of Munich, Munich, Germany.
5: Institute of Radiation Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
6: Department of Internal Medicine, Philipps University of Marburg, Marburg, Germany.
7: Department of Genetics, Cancer Genomics Netherlands, Erasmus Medical Center, Rotterdam, The Netherlands.
8: Department of Radiation Oncology, Erasmus Medical Center, Rotterdam, The Netherlands.
9: Institute of Medical Informatics, Biostatistics, and Epidemiology, Campus Grosshadern, University of Munich, Munich, Germany.
10: Department of Gastroenterology and Hepatology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.