MLL rearrangements impact outcome in HOXA-deregulated T-lineage acute lymphoblastic leukemia: a Children's Oncology Group Study.

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Published in Leukemia on March 08, 2016

Authors

K Matlawska-Wasowska1, H Kang2, M Devidas3, J Wen4, R C Harvey5, C K Nickl1, S A Ness6, M Rusch7, Y Li7, M Onozawa8,9, C Martinez1, B L Wood10, B L Asselin11, I-M Chen5, K G Roberts4, A Baruchel12, J Soulier12, H Dombret12, J Zhang7, R S Larson13, E A Raetz14, W L Carroll15, N J Winick16, P D Aplan8, M L Loh17, C G Mullighan4, S P Hunger18, N A Heerema19, A J Carroll20, K P Dunsmore21, S S Winter1

Author Affiliations

1: Divisions of Hematology-Oncology and Pediatric Research, Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
2: Division of Epidemiology, Biostatistics and Preventive Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
3: Department of Biostatistics, College of Medicine, University of Florida, Gainesville, FL, USA.
4: Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA.
5: Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
6: Department of Internal Medicine, Section of Molecular Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
7: Department of Computational Biology and Bioinformatics, St Jude Children's Research Hospital, Memphis, TN, USA.
8: Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
9: Department of Hematology, Center for Medical Education, Hokkaido University, Sapporo, Japan.
10: Department of Laboratory Medicine, University of Washington, Seattle, WA, USA.
11: Department of Pediatrics, University of Rochester Medical Center and School of Medicine, Rochester, NY, USA.
12: Hematology Laboratory, Institut Universitaire d'hematologie Hospital Saint-Louis, Paris, France.
13: Department of Pathology, University of New Mexico Health Science Center, UNM Clinical and Translational Science Center, Albuquerque, NM, USA.
14: Department of Pediatrics, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
15: Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York City, NY, USA.
16: Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
17: Department of Pediatrics, Benioff Children's Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA, USA.
18: Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
19: Department of Pathology, Ohio State University Wexner Medical Center, Columbus, OH, USA.
20: Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
21: Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.

Associated clinical trials:

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma | NCT00408005

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