Published in PLoS One on April 04, 2016
AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol (2012) 10.42
Islet beta cell failure in type 2 diabetes. J Clin Invest (2006) 7.67
Assessing mitochondrial dysfunction in cells. Biochem J (2011) 6.36
Diet-induced type II diabetes in C57BL/6J mice. Diabetes (1988) 6.26
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. Am J Physiol (1997) 5.74
Genetics of obesity in humans. Endocr Rev (2006) 5.42
Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev (2007) 4.91
Type 2 diabetes across generations: from pathophysiology to prevention and management. Lancet (2011) 3.50
Purification and characterization of the AMP-activated protein kinase. Copurification of acetyl-CoA carboxylase kinase and 3-hydroxy-3-methylglutaryl-CoA reductase kinase activities. Eur J Biochem (1989) 3.09
AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nat Rev Drug Discov (2004) 2.46
AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest (2013) 2.44
Fatty acid signaling in the beta-cell and insulin secretion. Diabetes (2006) 2.22
Metabolic signaling in fuel-induced insulin secretion. Cell Metab (2013) 2.00
Glycerolipid metabolism and signaling in health and disease. Endocr Rev (2008) 1.80
Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J (2003) 1.77
Beta-cell failure in diet-induced obese mice stratified according to body weight gain: secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass. Diabetes (2010) 1.66
Regulation of novel protein kinase C epsilon by phosphorylation. Biochem J (2002) 1.65
Banting lecture 2011: hyperinsulinemia: cause or consequence? Diabetes (2012) 1.64
Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice. Cell Metab (2009) 1.47
beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes (2007) 1.45
Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion. Proc Natl Acad Sci U S A (1993) 1.31
Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion. J Biol Chem (2009) 1.27
Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies. Am J Physiol Endocrinol Metab (2010) 1.26
A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets. PLoS One (2012) 1.25
Metformin, but not leptin, regulates AMP-activated protein kinase in pancreatic islets: impact on glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab (2004) 1.23
Evidence for a role of superoxide generation in glucose-induced beta-cell dysfunction in vivo. Diabetes (2007) 1.15
Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules. Diabetes (2011) 1.12
α/β-Hydrolase domain-6-accessible monoacylglycerol controls glucose-stimulated insulin secretion. Cell Metab (2014) 1.11
Mitochondrial dysfunction in pancreatic beta-cells in Type 2 diabetes. Mol Cell Endocrinol (2008) 1.09
UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival. Proc Natl Acad Sci U S A (2008) 1.09
Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles. Diabetes (2010) 1.06
The fatty acid receptor FFA1/GPR40 a decade later: how much do we know? Trends Endocrinol Metab (2013) 1.06
Glucose-induced posttranslational activation of protein phosphatases PP2A and PP1 in yeast. Cell Res (2012) 1.04
LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle. Am J Physiol Endocrinol Metab (2007) 1.03
Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 ss-cells. Endocrinology (2010) 1.03
The AMP-regulated kinase family: enigmatic targets for diabetes therapy. Mol Cell Endocrinol (2008) 1.03
Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise. Biochem Biophys Res Commun (2002) 1.02
Role of AMPK in pancreatic beta cell function. Mol Cell Endocrinol (2012) 1.00
A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis. Diabetologia (2008) 0.98
Mitochondrial function and insulin secretion. Mol Cell Endocrinol (2013) 0.97
Defective insulin secretory response to intravenous glucose in C57Bl/6J compared to C57Bl/6N mice. Mol Metab (2014) 0.95
Mitochondrial cholesterol in health and disease. Histol Histopathol (2009) 0.94
Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells. Diabetes (2009) 0.92
Cholesterol in beta-cell dysfunction: the emerging connection between HDL cholesterol and type 2 diabetes. Curr Diab Rep (2010) 0.90
Activation of acetyl-CoA carboxylase by a glutamate- and magnesium-sensitive protein phosphatase in the islet beta-cell. Diabetes (2001) 0.90
Mitochondrial medicine: a new era in medicine opens new windows and brings new challenges. Circulation (2008) 0.89
Defective glucose-stimulated insulin release from perifused islets of C57BL/6J mice. Pancreas (1995) 0.88
Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets. Physiol Behav (1995) 0.87
Mitochondrial dynamics and morphology in beta-cells. Best Pract Res Clin Endocrinol Metab (2012) 0.86
Obesity and type 2 diabetes: slow down!--Can metabolic deceleration protect the islet beta cell from excess nutrient-induced damage? Mol Cell Endocrinol (2009) 0.84
Metformin decreases high-fat diet-induced renal injury by regulating the expression of adipokines and the renal AMP-activated protein kinase/acetyl-CoA carboxylase pathway in mice. Int J Mol Med (2013) 0.84
Distinct pathways of cholesterol biosynthesis impact on insulin secretion. J Endocrinol (2015) 0.84
Accumulation of 3-hydroxytetradecenoic acid: Cause or corollary of glucolipotoxic impairment of pancreatic β-cell bioenergetics? Mol Metab (2015) 0.82
α/β-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli. Mol Metab (2015) 0.79
PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis. PLoS Genet (2015) 0.78