Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model.

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Published in Oncotarget on June 07, 2016

Authors

Eloah Rabello Suarez1,2,3, De Kuan Chang1,2, Jiusong Sun1,2, Jianhua Sui4, Gordon J Freeman2,5, Sabina Signoretti6, Quan Zhu1,2, Wayne A Marasco1,2

Author Affiliations

1: Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA.
2: Department of Medicine, Harvard Medical School, Boston, MA, USA.
3: Department of Biochemistry, Faculdade de Medicina do ABC, Av. Príncipe de Gales, SP, Brazil.
4: National Institute of Biological Sciences, ZGC Life Science Park, Changping, Beijing, China.
5: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
6: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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