Targeting immune checkpoints in unresectable metastatic cutaneous melanoma: a systematic review and meta-analysis of anti-CTLA-4 and anti-PD-1 agents trials.

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Published in Cancer Med on May 11, 2016

Authors

Seongseok Yun1,2, Nicole D Vincelette3, Myke R Green2, Andrea E Wahner Hendrickson4, Ivo Abraham5,6

Author Affiliations

1: Department of Medicine, University of Arizona, Tucson, Arizona, 85721.
2: Hematology and Oncology, University of Arizona, Tucson, Arizona, 85721.
3: Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, 55905.
4: Medical Oncology, Mayo Clinic, Rochester, Minnesota, 55905.
5: Center for Health Outcomes and PharmacoEconomic Research, University of Arizona, Tucson, Arizona, 85721.
6: Arizona Cancer Center, University of Arizona, Tucson, Arizona, 85721.

Associated clinical trials:

Dacarbazine and Ipilimumab vs. Dacarbazine With Placebo in Untreated Unresectable Stage III or IV Melanoma | NCT00324155

MDX-010 Antibody, MDX-1379 Melanoma Vaccine, or MDX-010/MDX-1379 Combination Treatment for Patients With Unresectable or Metastatic Melanoma | NCT00094653

Study of Nivolumab (BMS-936558) Compared With Dacarbazine in Untreated, Unresectable, or Metastatic Melanoma (CheckMate 066) | NCT01721772

A Study to Compare BMS-936558 to the Physician's Choice of Either Dacarbazine or Carboplatin and Paclitaxel in Advanced Melanoma Patients That Have Progressed Following Anti-CTLA-4 Therapy (CheckMate 037) | NCT01721746

Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Participants With Advanced Melanoma (P08719/KEYNOTE-002) | NCT01704287

CP-675,206 Versus Either Dacarbazine Or Temozolomide In Patients Without Prior Therapy | NCT00257205

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