Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy.

Role of Gasotransmitters in Oxidative Stresses, Neuroinflammation, and Neuronal Repair. Biomed Res Int (2017) 0.76

The role of heme oxygenase-1 (HO-1) in the regulation of inflammatory reaction, neuronal cell proliferation and apoptosis in rats after intracerebral hemorrhage (ICH). Neuropsychiatr Dis Treat (2016) 0.75

Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats. Front Cell Neurosci (2017) 0.75

Cordycepin confers neuroprotection in mice models of intracerebral hemorrhage via suppressing NLRP3 inflammasome activation. Metab Brain Dis (2017) 0.75

Hemoglobin enhances miRNA-144 expression and autophagic activation mediated inflammation of microglia via mTOR pathway. Sci Rep (2017) 0.75

Adoptive Regulatory T-cell Therapy Attenuates Perihematomal Inflammation in a Mouse Model of Experimental Intracerebral Hemorrhage. Cell Mol Neurobiol (2016) 0.75

The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev (2007) 21.13

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev (2004) 9.24

Metals, toxicity and oxidative stress. Curr Med Chem (2005) 7.48

Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal (2007) 5.17

Intracerebral haemorrhage. Lancet (2009) 5.15

Cost of disorders of the brain in Europe 2010. Eur Neuropsychopharmacol (2011) 4.63

Oxidative stress and cancer: have we moved forward? Biochem J (2007) 4.20

How human neutrophils kill and degrade microbes: an integrated view. Immunol Rev (2007) 3.97

Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2014) 3.48

Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli. Cell Prolif (1991) 2.81

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation. Nat Neurosci (2009) 2.71

Stress-response hormesis and aging: "that which does not kill us makes us stronger". Cell Metab (2008) 2.71

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol (2012) 2.62

Heme oxygenase-1 protein localizes to the nucleus and activates transcription factors important in oxidative stress. J Biol Chem (2007) 2.08

Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage. Brain (2007) 2.04

Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med (2011) 2.03

Oxidative stress and autophagy: the clash between damage and metabolic needs. Cell Death Differ (2014) 2.00

Attenuation of neurological injury with early baicalein treatment following subarachnoid hemorrhage in rats. J Neurosurg (2013) 2.00

Molecular pathophysiology of cerebral hemorrhage: secondary brain injury. Stroke (2011) 1.96

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat Med (2012) 1.90

Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT Trial. Stroke (2007) 1.75

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis. J Cell Biol (2010) 1.74

Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Free Radic Biol Med (2007) 1.73

Simvastatin in aneurysmal subarachnoid haemorrhage (STASH): a multicentre randomised phase 3 trial. Lancet Neurol (2014) 1.73

Cerebral blood flow regulation by nitric oxide: recent advances. Pharmacol Rev (2009) 1.61

ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and non-neurodegenerative lysosomal storage disorders and are alleviated by chemical chaperones. Hum Mol Genet (2007) 1.60

Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. Crit Care Med (2012) 1.60

Atherosclerosis and oxidative stress. Histol Histopathol (2008) 1.55

Reactive oxygen species and the modulation of stroke. Free Radic Biol Med (2005) 1.55

A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress. Front Cell Neurosci (2014) 1.53

Hemoglobin and iron handling in brain after subarachnoid hemorrhage and the effect of deferoxamine on early brain injury. J Cereb Blood Flow Metab (2010) 1.46

Association between serum ferritin level and perihematoma edema volume in patients with spontaneous intracerebral hemorrhage. Stroke (2008) 1.44

Protective effect of sulforaphane against oxidative stress: recent advances. Exp Toxicol Pathol (2010) 1.41

COL4A2 mutations impair COL4A1 and COL4A2 secretion and cause hemorrhagic stroke. Am J Hum Genet (2011) 1.38

Necroptosis: an emerging form of programmed cell death. Crit Rev Oncol Hematol (2011) 1.38

Matrix metalloproteinase-9 inhibition attenuates vascular endothelial growth factor-induced intracerebral hemorrhage. Stroke (2007) 1.38

Heme oxygenase 2 is neuroprotective against intracerebral hemorrhage. Neurobiol Dis (2006) 1.38

Role of NADPH oxidase in the brain injury of intracerebral hemorrhage. J Neurochem (2005) 1.37

An involvement of oxidative stress in endoplasmic reticulum stress and its associated diseases. Int J Mol Sci (2012) 1.37

Oxidative stress and endothelial dysfunction in cerebrovascular disease. Front Biosci (Landmark Ed) (2011) 1.34

Oxidative DNA injury after experimental intracerebral hemorrhage. Brain Res (2005) 1.30

Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathways. Arterioscler Thromb Vasc Biol (2010) 1.29

Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management. Am J Hematol (2011) 1.28

Role of oxidative stress in Parkinson's disease. Exp Neurobiol (2013) 1.23

Targeting the vicious inflammation-oxidative stress cycle for the management of heart failure. Antioxid Redox Signal (2010) 1.20

Hemin-induced necroptosis involves glutathione depletion in mouse astrocytes. Free Radic Biol Med (2008) 1.20

Safety and tolerability of deferoxamine mesylate in patients with acute intracerebral hemorrhage. Stroke (2011) 1.19

Edaravone attenuates brain edema and neurologic deficits in a rat model of acute intracerebral hemorrhage. Stroke (2007) 1.16

Iron-related brain damage in patients with intracerebral hemorrhage. Stroke (2010) 1.13

Autophagy after experimental intracerebral hemorrhage. J Cereb Blood Flow Metab (2007) 1.13

Circulating oxidized LDL: a biomarker and a pathogenic factor. Curr Opin Lipidol (2009) 1.12

Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage. J Neurosci Res (2011) 1.11

Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model. J Pineal Res (2012) 1.11

Mechanisms of hydrocephalus after neonatal and adult intraventricular hemorrhage. Transl Stroke Res (2012) 1.11

Hemoglobin-induced oxidative stress contributes to matrix metalloproteinase activation and blood-brain barrier dysfunction in vivo. J Cereb Blood Flow Metab (2010) 1.11

Deferoxamine reduces neuronal death and hematoma lysis after intracerebral hemorrhage in aged rats. Transl Stroke Res (2013) 1.10

Minocycline-induced attenuation of iron overload and brain injury after experimental intracerebral hemorrhage. Stroke (2011) 1.08

Hemin toxicity: a preventable source of brain damage following hemorrhagic stroke. Redox Rep (2009) 1.07

Neuroinflammation after intracerebral hemorrhage. Front Cell Neurosci (2014) 1.05

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms. Cell Mol Neurobiol (2015) 1.05

Endoplasmic reticulum stress and Nox-mediated reactive oxygen species signaling in the peripheral vasculature: potential role in hypertension. Antioxid Redox Signal (2013) 1.04

Oxidative stress: Biomarkers and novel therapeutic pathways. Exp Gerontol (2010) 1.04

Heme oxygenase 2 deficiency increases brain swelling and inflammation after intracerebral hemorrhage. Neuroscience (2008) 1.04

High dose deferoxamine in intracerebral hemorrhage (HI-DEF) trial: rationale, design, and methods. Neurocrit Care (2013) 1.04

Endoplasmic reticulum Ca(2+) release through ryanodine and IP(3) receptors contributes to neuronal excitotoxicity. Cell Calcium (2009) 1.03

Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability. Front Biosci (Schol Ed) (2011) 1.03

Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study. Neurology (2015) 1.03

Deferoxamine reduces CSF free iron levels following intracerebral hemorrhage. Acta Neurochir Suppl (2006) 1.03

Role of red blood cell lysis and iron in hydrocephalus after intraventricular hemorrhage. J Cereb Blood Flow Metab (2014) 1.00

Oxidative neurotoxicity in rat cerebral cortex neurons: synergistic effects of H2O2 and NO on apoptosis involving activation of p38 mitogen-activated protein kinase and caspase-3. J Neurosci Res (2003) 1.00

Raised plasma oxidised LDL in acute cerebral infarction. J Neurol Neurosurg Psychiatry (2003) 1.00

Toxic role of prostaglandin E2 receptor EP1 after intracerebral hemorrhage in mice. Brain Behav Immun (2015) 0.98

Redox modification of ryanodine receptors by mitochondria-derived reactive oxygen species contributes to aberrant Ca2+ handling in ageing rabbit hearts. J Physiol (2013) 0.98

Matrix metalloproteinases in human spontaneous intracerebral hemorrhage: an update. Cerebrovasc Dis (2012) 0.97

Failure of deferoxamine, an iron chelator, to improve outcome after collagenase-induced intracerebral hemorrhage in rats. Brain Res (2009) 0.96

The tyrosine phosphatase SHP2 modulates MAP kinase p38 and caspase 1 and 3 to foster neuronal survival. Cell Mol Neurobiol (2003) 0.96

Oxidative stress triggers neuronal caspase-independent death: endonuclease G involvement in programmed cell death-type III. Cell Mol Life Sci (2009) 0.96

Iron and intracerebral hemorrhage: from mechanism to translation. Transl Stroke Res (2013) 0.96

Activated autophagy pathway in experimental subarachnoid hemorrhage. Brain Res (2009) 0.94

Nox NADPH oxidases and the endoplasmic reticulum. Antioxid Redox Signal (2014) 0.94

Cleaning up after ICH: the role of Nrf2 in modulating microglia function and hematoma clearance. J Neurochem (2014) 0.93

Effect of a free radical scavenger, edaravone, in the treatment of patients with aneurysmal subarachnoid hemorrhage. Neurosurgery (2009) 0.92

Contribution of reactive oxygen species to cerebral amyloid angiopathy, vasomotor dysfunction, and microhemorrhage in aged Tg2576 mice. Proc Natl Acad Sci U S A (2015) 0.92

Amelioration of oxidative stress and protection against early brain injury by astaxanthin after experimental subarachnoid hemorrhage. J Neurosurg (2014) 0.92

Ferric iron chelation lowers brain iron levels after intracerebral hemorrhage in rats but does not improve outcome. Exp Neurol (2011) 0.92

Correlation of F4-neuroprostanes levels in cerebrospinal fluid with outcome of aneurysmal subarachnoid hemorrhage in humans. Free Radic Biol Med (2009) 0.91

Necroptosis, necrostatins and tissue injury. J Cell Mol Med (2011) 0.91

Nrf2 to pre-condition the brain against injury caused by products of hemolysis after ICH. Transl Stroke Res (2013) 0.91

Role of autophagy in early brain injury after experimental subarachnoid hemorrhage. J Mol Neurosci (2011) 0.91

Co-induction of heme oxygenase-1 and peroxiredoxin I in astrocytes and microglia around hemorrhagic region in the rat brain. Neurosci Lett (2000) 0.91

Resveratrol attenuates early brain injury after subarachnoid hemorrhage through inhibition of NF-κB-dependent inflammatory/MMP-9 pathway. CNS Neurosci Ther (2013) 0.91

Emerging experimental therapies for intracerebral hemorrhage: targeting mechanisms of secondary brain injury. Neurosurg Focus (2013) 0.90

ROS are required for rapid reactivation of Na+/Ca2+ exchanger in hypoxic reoxygenated guinea pig ventricular myocytes. Am J Physiol Heart Circ Physiol (2003) 0.90

Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications. Eur Heart J (2015) 0.90

Decreased uric acid levels correlate with poor outcomes in acute ischemic stroke patients, but not in cerebral hemorrhage patients. J Stroke Cerebrovasc Dis (2013) 0.89

Nitric oxide-derived oxidants with a focus on peroxynitrite: molecular targets, cellular responses and therapeutic implications. Curr Pharm Des (2011) 0.89

Metallothionein attenuates 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons. Antioxid Redox Signal (2003) 0.89

Intracerebral hemorrhage: a multimodality approach to improving outcome. Transl Stroke Res (2014) 0.89

Anti-necroptosis chemical necrostatin-1 can also suppress apoptotic and autophagic pathway to exert neuroprotective effect in mice intracerebral hemorrhage model. J Mol Neurosci (2014) 0.88

Bilirubin oxidation products, oxidative stress, and intracerebral hemorrhage. Acta Neurochir Suppl (2008) 0.88

NADPH Oxidase: A Potential Target for Treatment of Stroke. Oxid Med Cell Longev (2016) 0.78