Androgen-sensitive hypertension associated with soluble guanylate cyclase-α1 deficiency is mediated by 20-HETE.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27199131)

Published in Am J Physiol Heart Circ Physiol on May 03, 2016

Authors

Ana C Dordea1, Sara Vandenwijngaert1, Victor Garcia2, Robert E T Tainsh1, Daniel I Nathan1, Kaitlin Allen1, Michael J Raher1, Laurel T Tainsh1, Fan Zhang2, Wolfgang S Lieb1, Sarah Mikelman1, Andrew Kirby3, Christine Stevens4, Robrecht Thoonen1, Allyson G Hindle1, Patrick Y Sips5, John R Falck6, Mark J Daly7, Peter Brouckaert8, Kenneth D Bloch9, Donald B Bloch9, Rajeev Malhotra9, Michal L Schwartzman2, Emmanuel S Buys10

Author Affiliations

1: Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Research Institute, Harvard Medical School, Boston, Massachusetts;
2: Department of Pharmacology, New York Medical College, Valhalla, New York;
3: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts;
4: Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Techonology, Cambridge, Massachusetts;
5: Division of Cardiovascular Medicine, Department of Medicine Brigham and Women's Hospital, Boston, Massachusetts;
6: Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas;
7: Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Techonology, Cambridge, Massachusetts;
8: Department for Biomedical Molecular Biology, Ghent University, Ghent, Belgium; and.
9: Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Research Institute, Harvard Medical School, Boston, Massachusetts; Cardiology Division, Department of Medicine, Massachusetts General, Harvard Medical School, Boston, Massachusetts.
10: Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital Research Institute, Harvard Medical School, Boston, Massachusetts; ebuys@mgh.harvard.edu.

Articles citing this

Effect of Cytochrome P450 Metabolites of Arachidonic Acid in Nephrology. J Am Soc Nephrol (2017) 0.75

Articles cited by this

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44

Executive summary: heart disease and stroke statistics--2012 update: a report from the American Heart Association. Circulation (2012) 6.24

P-450 metabolites of arachidonic acid in the control of cardiovascular function. Physiol Rev (2002) 6.14

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics (2004) 5.12

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nat Genet (2011) 4.04

Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nat Genet (2009) 3.81

Gender differences in the regulation of blood pressure. Hypertension (2001) 3.78

Genetic analysis of inherited hypertension in the rat. Physiol Rev (2000) 2.78

Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation (2004) 2.35

Androgen-mediated induction of the kidney arachidonate hydroxylases is associated with the development of hypertension. Am J Physiol Regul Integr Comp Physiol (2003) 1.81

New target regions for human hypertension via comparative genomics. Genome Res (2000) 1.75

A haplotype of the CYP4A11 gene associated with essential hypertension in Japanese men. J Hypertens (2008) 1.62

Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci U S A (2001) 1.61

Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation. Biochem J (2007) 1.49

A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure. Hypertension (2008) 1.49

Functional polymorphism in human CYP4F2 decreases 20-HETE production. Physiol Genomics (2007) 1.47

Blood pressure loci identified with a gene-centric array. Am J Hum Genet (2011) 1.44

Gender-specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice. Cardiovasc Res (2008) 1.39

Heritability of daytime ambulatory blood pressure in an extended twin design. Hypertension (2004) 1.38

Urinary 20-hydroxyeicosatetraenoic acid is associated with endothelial dysfunction in humans. Circulation (2004) 1.27

Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation. Cardiovasc Res (2007) 1.23

sGC(alpha)1(beta)1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models. Am J Physiol Heart Circ Physiol (2009) 1.21

Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. Eur J Hum Genet (2009) 1.14

Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase. Hypertension (2011) 1.10

Association of a functional cytochrome P450 4F2 haplotype with urinary 20-HETE and hypertension. J Am Soc Nephrol (2008) 1.10

Sex and gender differences in control of blood pressure. Clin Sci (Lond) (2013) 1.08

CYP4A1 antisense oligonucleotide reduces mesenteric vascular reactivity and blood pressure in SHR. Am J Physiol Regul Integr Comp Physiol (2001) 1.07

Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study. J Hypertens (2009) 1.03

20-HETE and blood pressure regulation: clinical implications. Cardiol Rev (2013) 1.02

Genetic and molecular aspects of hypertension. Circ Res (2015) 1.01

Renin gene polymorphisms and haplotypes, blood pressure, and responses to renin-angiotensin system inhibition. Hypertension (2007) 0.99

Cardiovascular and renal phenotype in mice with one or two renin genes. Hypertension (2003) 0.98

Postmenopausal hypertension: role of 20-HETE. Am J Physiol Regul Integr Comp Physiol (2011) 0.98

New approaches in the treatment of hypertension. Circ Res (2015) 0.97

Induction of angiotensin-converting enzyme and activation of the renin-angiotensin system contribute to 20-hydroxyeicosatetraenoic acid-mediated endothelial dysfunction. Arterioscler Thromb Vasc Biol (2012) 0.95

Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase. J Am Soc Nephrol (2013) 0.94

Genetic modifiers of hypertension in soluble guanylate cyclase α1-deficient mice. J Clin Invest (2012) 0.88

The epidemiology of blood pressure and its worldwide management. Circ Res (2015) 0.87

Contribution of 20-HETE to augmented myogenic constriction in coronary arteries of endothelial NO synthase knockout mice. Hypertension (2005) 0.86

Testosterone-dependent increase in blood pressure is mediated by elevated Cyp4A expression in fructose-fed rats. Mol Cell Biochem (2011) 0.83

Role of 20-hydroxyeicosatetraenoic and epoxyeicosatrienoic acids in the regulation of vascular function in a model of hypertension and endothelial dysfunction. Pharmacology (2010) 0.81

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice. Nat Commun (2015) 0.78