CDX2 as a Prognostic Biomarker in Colon Cancer.

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Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. Nat Med (2013) 4.22

Loss of CDX2/CK20 expression is associated with poorly differentiated carcinoma, the CpG island methylator phenotype, and adverse prognosis in microsatellite-unstable colorectal cancer. Am J Surg Pathol (2013) 1.25

Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients. World J Gastroenterol (2015) 1.14

CDX2 as a Prognostic Biomarker in Colon Cancer. N Engl J Med (2016) 0.86

CDX2 as a Prognostic Biomarker in Colon Cancer. N Engl J Med (2016) 0.84

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Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev (2003) 20.77

Identification of pancreatic cancer stem cells. Cancer Res (2007) 18.36

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature (2003) 14.35

Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A (2007) 13.58

The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med (2007) 13.39

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature (2003) 11.23

Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature (2009) 10.31

Applying the principles of stem-cell biology to cancer. Nat Rev Cancer (2003) 8.95

CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer. N Engl J Med (2016) 8.53

Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell (2009) 8.33

Cancer stem cells: models and concepts. Annu Rev Med (2007) 8.06

Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol (2011) 7.84

The biology of cancer stem cells. Annu Rev Cell Dev Biol (2007) 6.23

Self-renewal and solid tumor stem cells. Oncogene (2004) 4.60

Stem cells in normal breast development and breast cancer. Cell Prolif (2003) 4.47

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A (2012) 4.20

Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One (2008) 3.97

Bmi1, stem cells, and senescence regulation. J Clin Invest (2004) 3.80

Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells (2007) 3.60

DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency. Cell Stem Cell (2009) 3.48

An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Nat Biotechnol (2011) 3.05

Therapeutic implications of cancer stem cells. Curr Opin Genet Dev (2004) 3.04

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci U S A (2011) 2.96

Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci U S A (2010) 2.89

Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors. Nature (2008) 2.82

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc Natl Acad Sci U S A (2009) 2.76

Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. Genes Dev (2009) 2.46

Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. Nat Med (2006) 2.23

Recent advances in cancer stem cells. Curr Opin Genet Dev (2008) 2.17

Cancer stem cells and radiotherapy: new insights into tumor radioresistance. J Natl Cancer Inst (2006) 2.10

Gene Expression Commons: an open platform for absolute gene expression profiling. PLoS One (2012) 1.96

Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer. J Clin Invest (2012) 1.92

The genome sequence of the colonial chordate, Botryllus schlosseri. Elife (2013) 1.86

MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets. Proc Natl Acad Sci U S A (2010) 1.82

Differential gene expression profiling of adult murine hematopoietic stem cells. Blood (2002) 1.69

Identification of a colonial chordate histocompatibility gene. Science (2013) 1.68

Immunity to cancer: attack and escape in T lymphocyte-tumor cell interaction. Immunol Rev (2002) 1.66

Three differentiation states risk-stratify bladder cancer into distinct subtypes. Proc Natl Acad Sci U S A (2012) 1.60

Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance. Cancer Res (2008) 1.58

Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells. Stem Cells (2007) 1.57

Cancer immunotherapy with peptide-based vaccines: what have we achieved? Where are we going? J Natl Cancer Inst (2002) 1.56

Therapeutic implications of the cancer stem cell hypothesis. Semin Radiat Oncol (2009) 1.53

Cancer stem cells and tumor metastasis: first steps into uncharted territory. Cell Stem Cell (2007) 1.48

MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun (2013) 1.43

Hematopoietic stem cell self-renewal. Curr Opin Genet Dev (2006) 1.42

A genetic determinant that specifically regulates the frequency of hematopoietic stem cells. J Immunol (2002) 1.41

Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature. Nat Cell Biol (2012) 1.38

Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Gastroenterology (2012) 1.32

Combined analysis of murine and human microarrays and ChIP analysis reveals genes associated with the ability of MYC to maintain tumorigenesis. PLoS Genet (2008) 1.23

Effects of time since fire on birds: how informative are generalized fire response curves for conservation management? Ecol Appl (2012) 1.22

Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells. Proc Natl Acad Sci U S A (2013) 1.19

Automated microfluidic chromatin immunoprecipitation from 2,000 cells. Lab Chip (2009) 1.17

Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature (2013) 1.13

MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. Breast Cancer Res Treat (2012) 1.07

The apoptosis inhibitor protein survivin induces tumor-specific CD8+ and CD4+ T cells in colorectal cancer patients. Cancer Res (2003) 1.06

Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells. Prostate (2009) 1.04

Innate immune response to homologous rotavirus infection in the small intestinal villous epithelium at single-cell resolution. Proc Natl Acad Sci U S A (2012) 0.99

New oncolytic adenoviruses with hypoxia- and estrogen receptor-regulated replication. Hum Gene Ther (2002) 0.99

Antigen-specific immunity in neuroblastoma patients: antibody and T-cell recognition of NY-ESO-1 tumor antigen. Cancer Res (2003) 0.93

Remodeling of endogenous mammary epithelium by breast cancer stem cells. Stem Cells (2012) 0.88

Optimal fire histories for biodiversity conservation. Conserv Biol (2014) 0.87

The 5th International Society for Stem Cell Research (ISSCR) Annual Meeting, June 2007. Stem Cells (2007) 0.87

The Myc connection: ES cells and cancer. Cell (2010) 0.87

Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials. Int J Radiat Oncol Biol Phys (2009) 0.83

Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex. Mol Cell Biol (2012) 0.83

Neurobiology: at the root of brain cancer. Nature (2004) 0.83

Oncogenic miRNAs and the perils of losing control of a stem cell's epigenetic identity. Cell Stem Cell (2013) 0.80

Comprehensive gene expression changes associated with mouse postnatal kidney development. J Urol (2012) 0.78

Identifying the metastatic seeds of breast cancer. Nat Biotechnol (2013) 0.78

SLUGging away at cell death. Cancer Cell (2002) 0.77

Removal of lactate dehydrogenase-elevating virus from human-in-mouse breast tumor xenografts by cell-sorting. J Virol Methods (2011) 0.76

Blood-cell banking for workers at the Fukushima Daiichi nuclear power plant. Lancet (2011) 0.75

Analysis of T1 Bladder Cancer on Biopsy and Transurethral Resection Specimens: Comparison and Ranking of T1 Quantification Approaches to Predict Progression to Muscularis Propria Invasion. Am J Surg Pathol (2017) 0.75