Abnormal X chromosome inactivation and sex-specific gene dysregulation after ablation of FBXL10.

PubWeight™: 0.78‹?›

🔗 View Article (PMID 27252784)

Published in Epigenetics Chromatin on May 31, 2016

Authors

Mathieu Boulard1, John R Edwards2, Timothy H Bestor1

Author Affiliations

1: Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 W. 168th St., New York, NY 10032 USA.
2: Center for Pharmacogenomics, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110 USA.

Articles cited by this

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46

TopHat: discovering splice junctions with RNA-Seq. Bioinformatics (2009) 81.13

Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet (2011) 6.06

Regulation of imprinted X-chromosome inactivation in mice by Tsix. Development (2001) 3.12

Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre. Nat Struct Mol Biol (2014) 2.65

Systematic discovery of Xist RNA binding proteins. Cell (2015) 2.26

JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes. Nature (2007) 2.20

Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation. Cell (2014) 2.20

Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12. Curr Biol (2000) 2.19

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands. Elife (2012) 1.99

Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. EMBO J (2006) 1.88

Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. Mol Cell (2013) 1.86

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development. PLoS Genet (2012) 1.67

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes. Nat Cell Biol (2013) 1.61

FBXL10 protects Polycomb-bound genes from hypermethylation. Nat Genet (2015) 1.60

Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly. Mol Cell Neurosci (2011) 1.15

The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development. Genes Dev (2015) 1.07

MOF-associated complexes ensure stem cell identity and Xist repression. Elife (2014) 1.06

NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells. Cancer Res (2014) 0.90

KDM2B is implicated in bovine lethal multi-organic developmental dysplasia. PLoS One (2012) 0.80