Pancreatic cancer from bench to bedside: molecular pathways and treatment options.

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🔗 View Article (PMID 27275478)

Published in Ann Transl Med on May 01, 2016

Authors

Christoforos Kosmidis1, Konstantinos Sapalidis1, Efstathios Kotidis1, Nikolaos Mixalopoulos1, Paul Zarogoulidis1, Drosos Tsavlis1, Sofia Baka1, Yan-Gao Man1, John Kanellos1

Author Affiliations

1: 1 3rd Department of Surgery, AUTH, University General Hospital of Thessaloniki AHEPA, Thessaloniki, Greece ; 2 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 3 Department of Oncology, Interbalkan Medical Center of Thessaloniki, Thessaloniki, Greece ; 4 Research Laboratory and International Collaboration, Bon Secours Cancer Institute, VA, USA.

Associated clinical trials:

Safety, Pharmacokinetics and Pharmacodynamics of BEZ235 Plus MEK162 in Selected Advanced Solid Tumor Patients | NCT01337765

Gemcitabine Hydrochloride With or Without Vismodegib in Treating Patients With Recurrent or Metastatic Pancreatic Cancer | NCT01064622

PEGPH20 Plus Nab-Paclitaxel Plus Gemcitabine Compared With Nab-Paclitaxel Plus Gemcitabine in Subjects With Stage IV Untreated Pancreatic Cancer (HALO-109-202) | NCT01839487

Gemcitabine Hydrochloride and Cisplatin With or Without Veliparib or Veliparib Alone in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer | NCT01585805

Hedgehog Inhibition for Pancreatic Ductal Adenocarcinoma (PDAC) in the Preoperative Setting (HIPPoS) (HIPPoS) | NCT01096732

Study to Assess the Safety & Tolerability of a PARP Inhibitor in Combination With Gemcitabine in Pancreatic Cancer | NCT00515866

M402 in Combination With Nab-Paclitaxel and Gemcitabine in Pancreatic Cancer | NCT01621243

Gemcitabine + Nab-paclitaxel With LDE-225 (Hedgehog Inhibitor) as Neoadjuvant Therapy for Pancreatic Adenocarcinoma | NCT01431794

A Safety and Efficacy Study of RX-0201 Plus Gemcitabine in Metastatic Pancreatic Cancer | NCT01028495

Dovitinib Lactate, Gemcitabine Hydrochloride, and Capecitabine in Treating Patients With Advanced or Metastatic Solid Tumors, Pancreatic Cancer and Biliary Cancers | NCT01497392

BKM120 + mFOLFOX6 in Advanced Solid Tumors With Expansion Cohort Pancreatic Cancer | NCT01571024

Afatinib as Cancer Therapy for Exocrine Pancreatic Tumours (ACCEPT) | NCT01728818

Treatment of Patients Suffering From a Progressive Pancreas Carcinoma With Everolimus (RAD001) and Gemcitabine | NCT00560963

Investigator's Initiated Phase II Study for Pancreatic Cancer Patients | NCT01659502

CCI-779 in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer | NCT00075647

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