CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART.

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Published in PLoS Pathog on July 14, 2016

Authors

Rémi Fromentin1, Wendy Bakeman2, Mariam B Lawani2, Gabriela Khoury3,4, Wendy Hartogensis5, Sandrina DaFonseca2, Marisela Killian6, Lorrie Epling6, Rebecca Hoh6, Elizabeth Sinclair6, Frederick M Hecht6, Peter Bacchetti5, Steven G Deeks6, Sharon R Lewin3,4, Rafick-Pierre Sékaly7, Nicolas Chomont1,2,8

Author Affiliations

1: Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
2: Vaccine and Gene Therapy Institute Florida, Port St Lucie, Florida, United States of America.
3: Department of Infectious Diseases, Monash University and Alfred Hospital, Melbourne, Victoria, Australia.
4: The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.
5: Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States of America.
6: Department of Medicine, University of California, San Francisco, California, United States of America.
7: Case Western Reserve University, Cleveland, Ohio, United States of America.
8: Department of Microbiology, Infectiology, and Immunology, Université de Montréal, Faculty of Medicine, Montreal, Quebec, Canada.

Associated clinical trials:

Safety Study of Anti-LAG-3 With and Without Anti-PD-1 in the Treatment of Solid Tumors | NCT01968109

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