Biopsy transcriptome expression profiling to identify kidney transplants at risk of chronic injury: a multicentre, prospective study.

PubWeight™: 2.80‹?› | Rank: Top 1%

🔗 View Article (PMID 27452608)

Published in Lancet on July 22, 2016

Authors

Philip J O'Connell1, Weijia Zhang2, Madhav C Menon2, Zhengzi Yi2, Bernd Schröppel2, Lorenzo Gallon3, Yi Luan2, Ivy A Rosales4, Yongchao Ge5, Bojan Losic6, Caixia Xi2, Christopher Woytovich2, Karen L Keung2, Chengguo Wei2, Ilana Greene2, Jessica Overbey7, Emilia Bagiella7, Nader Najafian8, Milagros Samaniego9, Arjang Djamali10, Stephen I Alexander11, Brian J Nankivell1, Jeremy R Chapman1, Rex Neal Smith4, Robert Colvin4, Barbara Murphy12

Author Affiliations

1: Renal Unit, University of Sydney at Westmead Hospital, Sydney, NSW, Australia.
2: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
3: Department of Medicine-Nephrology and Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
4: Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
5: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
6: Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
7: Department of Health Evidence and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
8: Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
9: Division of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, MI, USA.
10: Division of Nephrology, Department of Medicine, University of Wisconsin, Madison, WI, USA.
11: Discipline of Child & Adolescent Health, The Children's Hospital at Westmead Clinical School, The University of Sydney, NSW, Australia.
12: Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: barbara.murphy@mountsinai.org.

Associated clinical trials:

Genomics of Chronic Renal Allograft Rejection (The GoCAR Study) | NCT00611702

Articles cited by this

A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med (1999) 82.86

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature (2008) 10.73

The natural history of chronic allograft nephropathy. N Engl J Med (2003) 8.70

Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant (2008) 8.09

Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. Am J Transplant (2004) 4.04

Fibrosis--a common pathway to organ injury and failure. N Engl J Med (2015) 3.94

Clinical predictors of renal allograft histopathology: a comparative study of single-lesion histology versus a composite, quantitative scoring system. Transplantation (2007) 3.44

Identifying specific causes of kidney allograft loss. Am J Transplant (2008) 2.77

Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. Nat Cell Biol (2003) 2.71

Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes. Kidney Int (2011) 2.50

The histology of solitary renal allografts at 1 and 5 years after transplantation. Am J Transplant (2010) 2.40

OPTN/SRTR 2013 Annual Data Report: kidney. Am J Transplant (2015) 2.11

Predicting subsequent decline in kidney allograft function from early surveillance biopsies. Am J Transplant (2005) 1.79

Protocol core needle biopsy and histologic Chronic Allograft Damage Index (CADI) as surrogate end point for long-term graft survival in multicenter studies. J Am Soc Nephrol (2003) 1.77

Inflammation in areas of tubular atrophy in kidney allograft biopsies: a potent predictor of allograft failure. Am J Transplant (2010) 1.65

A molecular classifier for predicting future graft loss in late kidney transplant biopsies. J Clin Invest (2010) 1.61

Inhibition of angiogenesis by a mouse sprouty protein. J Biol Chem (2000) 1.54

Trends in organ donation and transplantation in the United States, 1999-2008. Am J Transplant (2010) 1.47

Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF. J Am Soc Nephrol (2004) 1.46

Histological chronic allograft damage index accurately predicts chronic renal allograft rejection. Transplantation (1994) 1.39

Hepatocyte growth factor prevents the development of chronic allograft nephropathy in rats. J Am Soc Nephrol (2001) 1.03

Molecular and structural consequences of early renal allograft injury. Kidney Int (2002) 1.03

Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells. J Biol Chem (2000) 0.88

Reduction of chronic allograft nephropathy by inhibition of extracellular signal-regulated kinase 1 and 2 signaling. Am J Physiol Renal Physiol (2008) 0.87

Protective effects of FR167653 on chronic allograft nephropathy by inhibiting p38 MAPK in rats. Transplant Proc (2008) 0.86

Protocol core needle biopsy and histological chronic allograft damage index as surrogate endpoint for Long-Term graft survival. Transplant Proc (2004) 0.85