CD28 co-stimulation in T-cell homeostasis: a recent perspective.

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Published in Immunotargets Ther on May 28, 2015

Authors

Niklas Beyersdorf1, Thomas Kerkau1, Thomas Hünig1

Author Affiliations

1: Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.

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Enhancement of antitumor immunity by CTLA-4 blockade. Science (1996) 17.94

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (1995) 16.19

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity (2000) 15.44

Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med (2006) 15.04

Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol Rev (2006) 10.24

CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med (1991) 9.94

The CD28 signaling pathway regulates glucose metabolism. Immunity (2002) 6.65

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL. Immunity (1995) 5.77

Calcium signalling in lymphocyte activation and disease. Nat Rev Immunol (2007) 5.62

Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol (2013) 5.36

Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science (1991) 5.12

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In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol Cell (2000) 4.10

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Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J Immunol (2003) 3.86

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma. J Exp Med (2013) 3.83

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Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J Immunol (2008) 3.23

CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol Rev (2009) 3.09

Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. J Immunol (1999) 2.77

Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells. Cancer Immunol Res (2013) 2.76

Both integrated and differential regulation of components of the IL-2/IL-2 receptor system. Cytokine Growth Factor Rev (2006) 2.71

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes. Nature (2002) 2.71

Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity (2002) 2.71

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Regulated expression of telomerase activity in human T lymphocyte development and activation. J Exp Med (1996) 2.60

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Crystal structure of a soluble CD28-Fab complex. Nat Immunol (2005) 2.46

The interaction properties of costimulatory molecules revisited. Immunity (2002) 2.43

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses. Nat Rev Immunol (2011) 2.36

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Proc Natl Acad Sci U S A (2002) 2.32

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Continuous requirement for the TCR in regulatory T cell function. Nat Immunol (2014) 2.11

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CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. Mol Cell Biol (1997) 1.83

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CD28 costimulation promotes the production of Th2 cytokines. J Immunol (1997) 1.78

CTLA4Ig: bridging the basic immunology with clinical application. Immunity (2006) 1.75

Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists. J Exp Med (2003) 1.70

Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo. Int Immunol (1996) 1.69

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The reverse stop-signal model for CTLA4 function. Nat Rev Immunol (2008) 1.60

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