S-Palmitoylation of a Novel Site in the β2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 27481942)

Published in J Biol Chem on August 01, 2016

Authors

Naoko Adachi1, Douglas T Hess1, Precious McLaughlin1, Jonathan S Stamler2

Author Affiliations

1: From the Institute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, Ohio 44106, the Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, and.
2: From the Institute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, Ohio 44106, the Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, and the Harrington Discovery Institute, University Hospitals Case Medical Center, Cleveland, Ohio 44106 jonathan.stamler@case.edu.

Articles citing this

Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis. Biomol Ther (Seoul) (2017) 0.79

Articles cited by this

Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature (2007) 14.06

All ras proteins are polyisoprenylated but only some are palmitoylated. Cell (1989) 9.68

Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science (2001) 5.05

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. J Biol Chem (2005) 4.91

Catecholamines: mediator of the hypermetabolic response to thermal injury. Ann Surg (1974) 4.48

Identification of PSD-95 palmitoylating enzymes. Neuron (2004) 4.37

Regulation of receptor trafficking by GRKs and arrestins. Annu Rev Physiol (2007) 4.17

A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A (2007) 3.82

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6. J Biol Chem (2001) 3.49

Conformational biosensors reveal GPCR signalling from endosomes. Nature (2013) 3.29

Large-scale profiling of protein palmitoylation in mammalian cells. Nat Methods (2009) 3.13

β-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol Sci (2011) 3.02

Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. J Biol Chem (1989) 2.95

Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture. Nat Biotechnol (2009) 2.69

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Sci Signal (2011) 2.56

Purification and properties of a palmitoyl-protein thioesterase that cleaves palmitate from H-Ras. J Biol Chem (1993) 2.52

Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Biochim Biophys Acta (2006) 2.49

DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. J Biol Chem (2005) 2.46

A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS). J Biol Chem (1998) 2.36

Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. J Biol Chem (1989) 2.10

Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking. Proc Natl Acad Sci U S A (2006) 1.97

Beta-adrenergic receptor subtype-specific signaling in cardiac myocytes from beta(1) and beta(2) adrenoceptor knockout mice. Mol Pharmacol (2001) 1.90

Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies. Mol Pharmacol (2004) 1.79

Molecular cloning and expression of palmitoyl-protein thioesterase. J Biol Chem (1994) 1.79

Site-specific analysis of protein S-acylation by resin-assisted capture. J Lipid Res (2010) 1.77

S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking. Mol Cell (2008) 1.63

Ras stabilization through aberrant activation of Wnt/β-catenin signaling promotes intestinal tumorigenesis. Sci Signal (2012) 1.56

Role of palmitoylation/depalmitoylation reactions in G-protein-coupled receptor function. Pharmacol Ther (2003) 1.55

Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. J Biol Chem (2002) 1.50

Acylation of bovine rhodopsin by [3H]palmitic acid. J Biol Chem (1984) 1.43

Regulation of G proteins by covalent modification. Oncogene (2001) 1.38

Discovery of protein-palmitoylating enzymes. Pflugers Arch (2008) 1.30

beta2-adrenergic receptor desensitization, internalization, and phosphorylation in response to full and partial agonists. J Biol Chem (1997) 1.30

Palmitoylated cysteine 341 modulates phosphorylation of the beta2-adrenergic receptor by the cAMP-dependent protein kinase. J Biol Chem (1996) 1.25

beta(2)-Adrenergic receptor signaling complexes in cardiomyocyte caveolae/lipid rafts. J Mol Cell Cardiol (2004) 1.24

The dually acylated NH2-terminal domain of gi1alpha is sufficient to target a green fluorescent protein reporter to caveolin-enriched plasma membrane domains. Palmitoylation of caveolin-1 is required for the recognition of dually acylated g-protein alpha subunits in vivo. J Biol Chem (1999) 1.22

Imaging the lipidome: omega-alkynyl fatty acids for detection and cellular visualization of lipid-modified proteins. ACS Chem Biol (2009) 1.21

Differential signaling of the endogenous agonists at the beta2-adrenergic receptor. J Biol Chem (2010) 1.20

Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry. J Lipid Res (2009) 1.20

Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43. PLoS One (2010) 1.18

Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity. J Biol Chem (1997) 1.14

Agonist stimulation increases the turnover rate of beta 2AR-bound palmitate and promotes receptor depalmitoylation. Biochemistry (1996) 1.00

Structural determinants of protein partitioning into ordered membrane domains and lipid rafts. Chem Phys Lipids (2015) 0.98

ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization. Elife (2015) 0.96

Differential regulation of two palmitoylation sites in the cytoplasmic tail of the beta1-adrenergic receptor. J Biol Chem (2011) 0.92

Crystallizing thinking about the beta2-adrenergic receptor. Mol Pharmacol (2008) 0.90

Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation. Medchemcomm (2014) 0.88

Downregulation of myocardial beta-adrenergic receptors. Receptor subtype selectivity. Circ Res (1994) 0.88

Palmitoylation regulates intracellular trafficking of β2 adrenergic receptor/arrestin/phosphodiesterase 4D complexes in cardiomyocytes. PLoS One (2012) 0.83