Published in Proc Natl Acad Sci U S A on July 01, 1989
Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens. Proc Natl Acad Sci U S A (1990) 2.22
Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med (2008) 1.89
Glutathione deficiency leads to mitochondrial damage in brain. Proc Natl Acad Sci U S A (1991) 1.43
Glutathione is required for intestinal function. Proc Natl Acad Sci U S A (1990) 1.43
Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress. Proc Natl Acad Sci U S A (1991) 1.43
Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage. Proc Natl Acad Sci U S A (1989) 1.37
High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function. Proc Natl Acad Sci U S A (1990) 1.32
Glutathione deficiency decreases tissue ascorbate levels in newborn rats: ascorbate spares glutathione and protects. Proc Natl Acad Sci U S A (1991) 1.27
Cysteine and glutathione concentrations in plasma and bronchoalveolar lavage fluid after treatment with N-acetylcysteine. Thorax (1991) 1.26
Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. J Clin Invest (1994) 1.22
Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats. Tracer kinetic studies in vitro and in vivo and susceptibility to oxidant stress. J Clin Invest (1991) 1.18
Ascorbic acid prevents oxidative stress in glutathione-deficient mice: effects on lung type 2 cell lamellar bodies, lung surfactant, and skeletal muscle. Proc Natl Acad Sci U S A (1992) 1.05
Toxic oxidant species and their impact on the pulmonary surfactant system. Lung (1997) 1.01
Augmentation of glutathione in the fluid lining the epithelium of the lower respiratory tract by directly administering glutathione aerosol. Proc Natl Acad Sci U S A (1990) 0.99
Glutathione deficiency increases hepatic ascorbic acid synthesis in adult mice. Proc Natl Acad Sci U S A (1992) 0.95
Alveolar type II cell abnormalities and peroxide formation in lungs of rats given IL-1 intratracheally. Inflammation (2000) 0.91
Glutathione ester delays the onset of scurvy in ascorbate-deficient guinea pigs. Proc Natl Acad Sci U S A (1993) 0.86
Inhibiting lung lining fluid glutathione metabolism with GGsTop as a novel treatment for asthma. Front Pharmacol (2014) 0.83
CFTR activity and mitochondrial function. Redox Biol (2013) 0.79
N-acetylcysteine in COPD: why, how, and when? Multidiscip Respir Med (2016) 0.76
Characterization of mitochondrial function in cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function. J Bioenerg Biomembr (2016) 0.75
Effect of acute ozone exposure on the lung metabolomes of obese and lean mice. PLoS One (2017) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
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Single-step separation of red blood cells. Granulocytes and mononuclear leukocytes on discontinuous density gradients of Ficoll-Hypaque. J Immunol Methods (1974) 8.28
Normal alveolar epithelial lining fluid contains high levels of glutathione. J Appl Physiol (1985) (1987) 3.51
Glutathione: interorgan translocation, turnover, and metabolism. Proc Natl Acad Sci U S A (1979) 2.71
Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J Biol Chem (1982) 2.48
Origin and turnover of mitochondrial glutathione. Proc Natl Acad Sci U S A (1985) 2.37
Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase. J Biol Chem (1979) 1.91
Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione. Arch Biochem Biophys (1985) 1.82
gamma-Glutamyl transpeptidase, a lymphoid cell-surface marker: relationship to blastogenesis, differentiation, and neoplasia. Proc Natl Acad Sci U S A (1976) 1.78
gamma-Glutamyl transpeptidase from kidney. Methods Enzymol (1985) 1.69
Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione monoester. Proc Natl Acad Sci U S A (1989) 1.66
Overview--preparation and properties of mitochondria from different sources. Methods Enzymol (1979) 1.36
Transport of glutathione, as gamma-glutamylcysteinylglycyl ester, into liver and kidney. Proc Natl Acad Sci U S A (1983) 1.35
Direct evidence for inter-organ transport of glutathione and that the non-filtration renal mechanism for glutathione utilization involves gamma-glutamyl transpeptidase. Biochem Biophys Res Commun (1980) 1.29
Organization of Krebs tricarboxylic acid cycle enzymes in mitochondria. J Biol Chem (1985) 1.29
Glutathione and gamma-glutamyl cycle enzymes in crypt and villus tip cells of rat jejunal mucosa. Proc Natl Acad Sci U S A (1976) 1.25
Intermediates of the gamma-glutamyl cycle in mouse tissues. Influence of administration of amino acids on pyrrolidone carboxylate and gamma-glutamyl amino acids. Eur J Biochem (1975) 1.19
Dynamic state of glutathione in blood plasma. J Biol Chem (1980) 1.13
Conversion of glutathione to glutathione disulfide by cell membrane-bound oxidase activity. Proc Natl Acad Sci U S A (1979) 1.10
The behavioral effects of phencyclidines may be due to their blockade of potassium channels. Proc Natl Acad Sci U S A (1981) 1.06
A simple specific method for the determination of the hemoglobin content of tissue homogenates. Clin Chim Acta (1979) 1.05
Biochemical assays in lung homogenates: artifacts caused by trapped blood after perfusion. Toxicol Appl Pharmacol (1979) 0.96
Glutathione biosynthesis in the isolated perfused rat lung: utilization of extracellular glutathione. FEBS Lett (1984) 0.94
Relationship of in vivo erythrocyte glutathione flux to the oxidized glutathione transport system. J Lab Clin Med (1974) 0.93
Method for determination of free and total glutathione and gamma-glutamylcysteine concentrations in human leukocytes and plasma. J Chromatogr (1987) 0.89
The effect of fasting on leukocyte and plasma glutathione and sulfur amino acid concentrations. Metabolism (1986) 0.88
Glutathione conjugation by isolated lung cells and the isolated, perfused lung. Effect of extracellular glutathione. Eur J Biochem (1984) 0.86
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FK 506 for liver, kidney, and pancreas transplantation. Lancet (1989) 13.70
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Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem (1979) 7.16
Liver, kidney, and thoracic organ transplantation under FK 506. Ann Surg (1990) 5.01
Conversion from cyclosporine to FK 506 in liver allograft recipients with cyclosporine-related complications. Transplant Proc (1990) 4.90
Histopathologic variability in usual and nonspecific interstitial pneumonias. Am J Respir Crit Care Med (2001) 4.01
Glutathione and related gamma-glutamyl compounds: biosynthesis and utilization. Annu Rev Biochem (1976) 3.84
Selective modification of glutathione metabolism. Science (1983) 3.64
Implementation of a high-sensitivity Micro-Angiographic Fluoroscope (HS-MAF) for in-vivo endovascular image guided interventions (EIGI) and region-of-interest computed tomography (ROI-CT). Proc SPIE Int Soc Opt Eng (2008) 3.49
Early trials with FK 506 as primary treatment in liver transplantation. Transplant Proc (1990) 3.29
On the enzymology of amino acid transport. Science (1973) 3.24
Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione. J Biol Chem (1975) 3.23
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. Proc Natl Acad Sci U S A (1992) 3.22
Interaction of gamma-glutamyl transpeptidase with amino acids, dipeptides, and derivatives and analogs of glutathione. J Biol Chem (1974) 3.18
The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver. Transplantation (1991) 3.14
The gamma-glutamyl cycle: a possible transport system for amino acids. Proc Natl Acad Sci U S A (1970) 3.13
Studies on the mechanism of inhibition of glutamine synthetase by methionine sulfoximine. Biochemistry (1969) 3.10
Cytologically integrated physical restriction fragment length polymorphism maps for the barley genome based on translocation breakpoints. Genetics (2000) 3.05
Cadaveric small bowel and small bowel-liver transplantation in humans. Transplantation (1992) 2.75
Glutathione: interorgan translocation, turnover, and metabolism. Proc Natl Acad Sci U S A (1979) 2.71
A randomized trial of primary liver transplantation under immunosuppression with FK 506 vs cyclosporine. Transplant Proc (1991) 2.49
Pharmacokinetics of FK 506: preclinical and clinical studies. Transplant Proc (1990) 2.48
Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs. Genes Dev (1990) 2.46
Maternal feeding practices and beliefs and their relationships to overweight in early childhood. J Dev Behav Pediatr (2001) 2.39
Origin and turnover of mitochondrial glutathione. Proc Natl Acad Sci U S A (1985) 2.37
The effects of FK 506 on renal function after liver transplantation. Transplant Proc (1990) 2.31
Conversion of liver allograft recipients from cyclosporine to FK 506-based immunosuppression: benefits and pitfalls. Transplant Proc (1991) 2.26
Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens. Proc Natl Acad Sci U S A (1990) 2.22
Elevated serum bone sialoprotein and osteopontin in colon, breast, prostate, and lung cancer. Clin Cancer Res (2001) 2.22
Translocation of intracellular glutathione to membrane-bound gamma-glutamyl transpeptidase as a discrete step in the gamma-glutamyl cycle: glutathionuria after inhibition of transpeptidase. Proc Natl Acad Sci U S A (1979) 2.20
Clinical significance of histological classification of idiopathic interstitial pneumonia. Eur Respir J (2002) 2.19
Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice. Gastroenterology (1999) 2.15
Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase. J Biol Chem (1993) 2.13
Cardiovascular risk assessment of South Asians in a religious setting: a feasibility study. Int J Clin Pract (2011) 2.12
An efficient screen for reproductive pathways using mature seeds of monocots and dicots. Plant J (2000) 2.11
One hundred ten consecutive primary orthotopic liver transplants under FK 506 in adults. Transplant Proc (1991) 2.10
Reduction in radiation exposure during coronary angiography. Cathet Cardiovasc Diagn (1990) 2.03
Serine-borate complex as a transition-state inhibitor of gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A (1978) 2.03
gamma-Glutamyl transpeptidase: catalytic, structural and functional aspects. Mol Cell Biochem (1981) 1.98
Clinical pharmacokinetics of tacrolimus. Clin Pharmacokinet (1995) 1.96
BCL-6 expression during B-cell activation. Blood (1996) 1.95
Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase. J Biol Chem (1979) 1.91
The specificity of glutamine synthetase and its relationship to substrate conformation at the active site. Adv Enzymol Relat Areas Mol Biol (1968) 1.91
Enzymatic conversion of 5-oxo-L-proline (L-pyrrolidone carboxylate) to L-glutamate coupled with cleavage of adenosine triphosphate to adenosine diphosphate, a reaction in the -glutamyl cycle. Proc Natl Acad Sci U S A (1971) 1.90
Isolation and properties of gamma-L-glutamylcyclotransferase from human brain. Biochemistry (1969) 1.89
Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione. Arch Biochem Biophys (1985) 1.82
Identification of L-methionine S-sulfoximine as the diastereoisomer of L-methionine SR-sulfoximine that inhibits glutamine synthetase. Biochemistry (1969) 1.82
gamma-Glutamyl transpeptidase, a lymphoid cell-surface marker: relationship to blastogenesis, differentiation, and neoplasia. Proc Natl Acad Sci U S A (1976) 1.78
Glutathione export by human lymphoid cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation. Proc Natl Acad Sci U S A (1981) 1.77
Evidence that the gamma-glutamyl cycle functions in vivo using intracellular glutathione: effects of amino acids and selective inhibition of enzymes. Proc Natl Acad Sci U S A (1978) 1.77
Studies on glutamine synthetase from Escherichia coli. Formation of pyrrolidone carboxylate and inhibition by methionine sulfoximine. J Biol Chem (1973) 1.76
Histone H4 acetylation of euchromatin and heterochromatin is cell cycle dependent and correlated with replication rather than with transcription. Plant Cell (2000) 1.75
Infections in adult liver transplant patients under FK 506 immunosuppression. Transplant Proc (1991) 1.75
Investigating the thyroid nodule. BMJ (2009) 1.73
Phosphorylation of methionine sulfoximine by glutamine synthetase. Proc Natl Acad Sci U S A (1968) 1.72
The Pittsburgh randomized trial of tacrolimus compared to cyclosporine for hepatic transplantation. J Am Coll Surg (1996) 1.71
gamma-Glutamyl transpeptidase from kidney. Methods Enzymol (1985) 1.69
Pharmacokinetics of FK 506 following oral administration: a comparison of FK 506 and cyclosporine. Transplant Proc (1991) 1.69
Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione monoester. Proc Natl Acad Sci U S A (1989) 1.66
Association of Enzymatic Activity with Submicroscopic Particles. Science (1952) 1.65
Gamma-glutamyl transpeptidase. Methods Enzymol (1981) 1.63
The question of FK 506 nephrotoxicity after liver transplantation. Transplant Proc (1991) 1.60
Accuracy and applicability of the revised WHO classification (2009) of dengue in children seen at a tertiary healthcare facility in northern India. Infection (2013) 1.59
Control of Escherichia coli carbamyl phosphate synthetase by purine and pyrimidine nucleotides. Biochemistry (1966) 1.58
Oral glucose tolerance test in liver recipients treated with FK 506. Transplant Proc (1990) 1.56
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Ambiguous coronary angiography: clinical utility of intravascular ultrasound. Cathet Cardiovasc Diagn (1992) 1.54
Morphological effects of coronary balloon angioplasty in vivo assessed by intravascular ultrasound imaging. Circulation (1992) 1.53
Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids. Proc Natl Acad Sci U S A (1982) 1.52
Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase. J Biol Chem (1993) 1.52
Concurrent dengue virus and Japanese encephalitis virus infection of the brain: is it co-infection or co-detection? Infection (2012) 1.52
Polymerase chain reaction vs. conventional diagnosis in fine needle aspirates of tuberculous lymph nodes. Acta Cytol (2001) 1.51
Glutathione synthetase deficiency, an inborn error of metabolism involving the gamma-glutamyl cycle in patients with 5-oxoprolinuria (pyroglutamic aciduria). Proc Natl Acad Sci U S A (1974) 1.51
Glutathione biosynthesis; gamma-glutamylcysteine synthetase from rat kidney. Methods Enzymol (1985) 1.50
Identity of maleate-stimulated glutaminase with gamma-glutamyl transpeptidase in rat kidney. J Biol Chem (1975) 1.50
Asparagine synthetase activity of mouse leukemias. Science (1968) 1.49
An analysis of early renal transplant protocol biopsies--the high incidence of subclinical tubulitis. Am J Transplant (2001) 1.48
Bacteriology of neonatal septicaemia in a tertiary care hospital of northern India. Indian J Med Microbiol (2007) 1.48
Converted laparoscopic colorectal surgery. Surg Endosc (2001) 1.48
Tripeptide (glutathione) synthetase. Purification, properties, and mechanism of action. Biochemistry (1967) 1.46
Affinity labeling of gamma-glutamyl transpeptidase and location of the gamma-glutamyl binding site on the light subunit. Proc Natl Acad Sci U S A (1977) 1.45
Transport and direct utilization of gamma-glutamylcyst(e)ine for glutathione synthesis. Proc Natl Acad Sci U S A (1983) 1.45
Conversion of liver allograft recipients from cyclosporine to FK506 immunosuppressive therapy--a clinicopathologic study of 96 patients. Transplantation (1992) 1.45
Glutamine-dependent asparagine synthetase from leukemia cells. Chloride dependence, mechanism of action, and inhibition. J Biol Chem (1972) 1.45
Glutathione, a first line of defense against cadmium toxicity. FASEB J (1987) 1.44
Reversible dissociation of gamma-glutamylcysteine synthetase into two subunits. J Biol Chem (1984) 1.44
Coronary artery fistula related to dilatation of totally occluded vessel. Clin Cardiol (1993) 1.44
Glutathione is required for intestinal function. Proc Natl Acad Sci U S A (1990) 1.43
Enzymes of the gamma-glutamyl cycle in the ciliary body and lens. Proc Natl Acad Sci U S A (1973) 1.43
Transversus abdominis plane block using the loss of resistance to air technique. Minerva Anestesiol (2012) 1.43
Glutathione deficiency leads to mitochondrial damage in brain. Proc Natl Acad Sci U S A (1991) 1.43
Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress. Proc Natl Acad Sci U S A (1991) 1.43
The gamma-glutamyl cycle. Diseases associated with specific enzyme deficiencies. Ann Intern Med (1974) 1.43