Topical treatment of melanoma metastases with imiquimod, plus administration of a cancer vaccine, promotes immune signatures in the metastases.

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Published in Cancer Immunol Immunother on August 13, 2016

Authors

Ileana S Mauldin1, Nolan A Wages2, Anne M Stowman1, Ena Wang3, Walter C Olson1, Donna H Deacon1, Kelly T Smith1, Nadedja Galeassi1, Jessica E Teague4,5, Mark E Smolkin2, Kimberly A Chianese-Bullock1, Rachael A Clark4,5, Gina R Petroni2, Francesco M Marincola3, David W Mullins6, Craig L Slingluff7

Author Affiliations

1: Division of Surgical Oncology, Department of Surgery, Human Immune Therapy Center, Cancer Center, University of Virginia, 1352 Jordan Hall, P.O. Box 801457, Charlottesville, VA, 22908, USA.
2: Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
3: Research Branch, Sidra Medical and Research Center, Doha, Qatar.
4: Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
5: Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, USA.
6: Department of Microbiology and Immunology, Norris-Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
7: Division of Surgical Oncology, Department of Surgery, Human Immune Therapy Center, Cancer Center, University of Virginia, 1352 Jordan Hall, P.O. Box 801457, Charlottesville, VA, 22908, USA. cls8h@virginia.edu.

Associated clinical trials:

Combination Therapy of Topical Imiquimod Plus Multipeptide Vaccination for Cutaneous Metastases of Melanoma (MEL53) | NCT01264731

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