Published in PLoS Genet on August 17, 2016
Study of COPD Subgroups and Biomarkers (SPIROMICS) | NCT01969344
Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts. Am J Respir Crit Care Med (2016) 0.78
Using omics approaches to understand pulmonary diseases. Respir Res (2017) 0.75
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Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci. PLoS Genet (2011) 1.10
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Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels. PLoS Genet (2013) 0.97
Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels. Am J Hum Genet (2014) 0.96
A genome wide association study identifies common variants associated with lipid levels in the Chinese population. PLoS One (2013) 0.95
Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. Hum Mol Genet (2013) 0.95
Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study. J Transl Med (2014) 0.93
Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links. PLoS Genet (2014) 0.91
A genome-wide association study of circulating galectin-3. PLoS One (2012) 0.89
The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes. Respir Res (2014) 0.88
Fibroblast-epithelial cell interactions drive epithelial-mesenchymal transition differently in cells from normal and COPD patients. Respir Res (2015) 0.87
Serum concentrations of C3 and C4 of the complement system in patients with chronic obstructive pulmonary disease. J Lab Clin Med (1980) 0.87
Vitamin D-Binding Protein Concentrations Quantified by Mass Spectrometry. N Engl J Med (2015) 0.84
Alterations in immunoglobulin & complement levels in chronic obstructive pulmonary disease. Indian J Med Res (1990) 0.83
Proteomic studies related to genetic determinants of variability in protein concentrations. J Proteome Res (2013) 0.82
Genome-wide association study on serum alkaline phosphatase levels in a Chinese population. BMC Genomics (2013) 0.81
Circulating Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Biomarker of Emphysema and the RAGE Axis in the Lung. Am J Respir Crit Care Med (2015) 0.81
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The Effect of Statins on Blood Gene Expression in COPD. PLoS One (2015) 0.79
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Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology (2011) 3.30
Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction. Thorax (2013) 2.88
The clinical features of the overlap between COPD and asthma. Respir Res (2011) 2.29
Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease. Thorax (2012) 2.15
The chronic bronchitic phenotype of COPD: an analysis of the COPDGene Study. Chest (2011) 2.14
Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med (2011) 2.06
Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax (2013) 1.99
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98
Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med (2012) 1.80
Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study. Am J Respir Crit Care Med (2011) 1.76
Racial differences in quality of life in patients with COPD. Chest (2011) 1.64
Association Between Interstitial Lung Abnormalities and All-Cause Mortality. JAMA (2016) 1.61
Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. Am J Respir Crit Care Med (2014) 1.57
Reduced Bone Density and Vertebral Fractures in Smokers. Men and COPD Patients at Increased Risk. Ann Am Thorac Soc (2015) 1.54
β-Blockers are associated with a reduction in COPD exacerbations. Thorax (2015) 1.48
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Quantitative computed tomography of the lungs and airways in healthy nonsmoking adults. Invest Radiol (2012) 1.41
Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med (2012) 1.27
The clinical impact of non-obstructive chronic bronchitis in current and former smokers. Respir Med (2013) 1.23
Genome-wide association study of smoking behaviours in patients with COPD. Thorax (2011) 1.18
Association between Functional Small Airway Disease and FEV1 Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 1.07
Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. Respir Res (2014) 1.06
Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT scan in subjects with COPD. Chest (2011) 1.03
Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. Chest (2011) 1.03
Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD. Respir Res (2013) 1.00
Family history is a risk factor for COPD. Chest (2011) 0.96
Racial differences in CT phenotypes in COPD. COPD (2013) 0.95
Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 0.92
Pulmonary function reduction in diabetes with and without chronic obstructive pulmonary disease. Diabetes Care (2013) 0.89
Association between occupational exposure and lung function, respiratory symptoms, and high-resolution computed tomography imaging in COPDGene. Am J Respir Crit Care Med (2014) 0.89
Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study. BMC Pulm Med (2016) 0.87
Occupational exposures are associated with worse morbidity in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 0.87
Analysis of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome Defined on the Basis of Bronchodilator Response and Degree of Emphysema. Ann Am Thorac Soc (2016) 0.87
Characterizing functional lung heterogeneity in COPD using reference equations for CT scan-measured lobar volumes. Chest (2013) 0.86
SPIROMICS Protocol for Multicenter Quantitative Computed Tomography to Phenotype the Lungs. Am J Respir Crit Care Med (2016) 0.86
Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort. BMC Pulm Med (2016) 0.86
Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene. Ann Am Thorac Soc (2015) 0.85
Impact of self-reported gastroesophageal reflux disease in subjects from COPDGene cohort. Respir Res (2014) 0.84
Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study. Respir Res (2015) 0.84
"B" for Bad, Beneficial, or Both? Lung Lymphoid Neogenesis in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2015) 0.83
Admixture mapping identifies a quantitative trait locus associated with FEV1/FVC in the COPDGene Study. Genet Epidemiol (2014) 0.82
Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 0.81
Cardiovascular disease is associated with COPD severity and reduced functional status and quality of life. COPD (2014) 0.81
Persistent and Newly Developed Chronic Bronchitis Are Associated with Worse Outcomes in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc (2016) 0.80
Bacterial Topography of the Healthy Human Lower Respiratory Tract. MBio (2017) 0.79
Obesity is Associated with Increased Morbidity in Moderate to Severe COPD. Chest (2016) 0.79
Clinical Implications of Having Reduced Mid Forced Expiratory Flow Rates (FEF25-75), Independently of FEV1, in Adult Patients with Asthma. PLoS One (2015) 0.79
Glucocorticoid-Augmented Efferocytosis Inhibits Pulmonary Pneumococcal Clearance in Mice by Reducing Alveolar Macrophage Bactericidal Function. J Immunol (2015) 0.79
Effect of Emphysema Severity on the Apnea-Hypopnea Index in Smokers with Obstructive Sleep Apnea. Ann Am Thorac Soc (2016) 0.79
CT-derived Biomechanical Metrics Improve Agreement Between Spirometry and Emphysema. Acad Radiol (2016) 0.78
Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. Respir Med (2014) 0.78
Airway wall thickness is increased in COPD patients with bronchodilator responsiveness. Respir Res (2014) 0.78
Lung Mass in Smokers. Acad Radiol (2016) 0.77
Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease. Ann Am Thorac Soc (2014) 0.77
Current Smoking Status Is Associated With Lower Quantitative CT Measures of Emphysema and Gas Trapping. J Thorac Imaging (2016) 0.77
Childhood-onset asthma in smokers. association between CT measures of airway size, lung function, and chronic airflow obstruction. Ann Am Thorac Soc (2014) 0.77
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet (2015) 0.77
Biomechanical CT metrics are associated with patient outcomes in COPD. Thorax (2017) 0.77
Sex-specific features of emphysema among current and former smokers with COPD. Eur Respir J (2015) 0.76
Multiplanar MDCT measurement of esophageal hiatus surface area: association with hiatal hernia and GERD. Surg Endosc (2015) 0.76
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet (2017) 0.76
MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1. J Immunol (2015) 0.76
Transforming growth factor-β induces microRNA-29b to promote murine alveolar macrophage dysfunction after bone marrow transplantation. Am J Physiol Lung Cell Mol Physiol (2014) 0.76
A Hairline Crack in the Levee: Focal Secretory IgA Deficiency as a First Step toward Emphysema. Am J Respir Crit Care Med (2017) 0.75
At the Checkpoint: Lung CD8(+) T Cells, Respiratory Viruses, and Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 0.75
Acute Exacerbations and Lung Function Loss in Smokers With and Without COPD. Am J Respir Crit Care Med (2016) 0.75
GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease. Respir Res (2017) 0.75
Scavenger Receptor MARCO Orchestrates Early Defenses and Contributes to Fungal Containment during Cryptococcal Infection. J Immunol (2017) 0.75
Post-imaging pulmonary nodule mathematical prediction models: are they clinically relevant? Eur Radiol (2019) 0.75
Ventricular Geometry From Non-contrast Non-ECG-gated CT Scans: An Imaging Marker of Cardiopulmonary Disease in Smokers. Acad Radiol (2017) 0.75
Clinical and Genetic Associations of Objectively Identified Interstitial Changes in Smokers. Chest (2017) 0.75
CT Measure of Lung At-risk and Lung Function Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2017) 0.75
Signs of Gas Trapping in Normal Lung Density Regions in Smokers. Am J Respir Crit Care Med (2017) 0.75
Genetic Association and Risk Scores in a COPD Meta-Analysis of 16,707 Subjects. Am J Respir Cell Mol Biol (2017) 0.75
Variability in objective and subjective measures affects baseline values in studies of patients with COPD. PLoS One (2017) 0.75
Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression. Chest (2017) 0.75
Measurement of Short-Chain Fatty Acids in Respiratory Samples: Keep Your Assay above the Water Line. Am J Respir Crit Care Med (2020) 0.75
Handgrip Strength in Chronic Obstructive Pulmonary Disease. Associations with Acute Exacerbations and Body Composition. Ann Am Thorac Soc (2017) 0.75