Published in J Clin Invest on August 01, 1978
The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice. Proc Natl Acad Sci U S A (2002) 2.72
The Streptococcus pneumoniae capsule inhibits complement activity and neutrophil phagocytosis by multiple mechanisms. Infect Immun (2009) 2.09
Pseudomonas aeruginosa suppresses host immunity by activating the DAF-2 insulin-like signaling pathway in Caenorhabditis elegans. PLoS Pathog (2008) 1.83
Cystic fibrosis pseudomonas opsonins. Inhibitory nature in an in vitro phagocytic assay. J Clin Invest (1981) 1.57
Role of coagulase in a murine model of hematogenous pulmonary infection induced by intravenous injection of Staphylococcus aureus enmeshed in agar beads. Infect Immun (1997) 1.57
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Three surface exoglycosidases from Streptococcus pneumoniae, NanA, BgaA, and StrH, promote resistance to opsonophagocytic killing by human neutrophils. Infect Immun (2010) 1.32
Pseudomonas aeruginosa Psl polysaccharide reduces neutrophil phagocytosis and the oxidative response by limiting complement-mediated opsonization. Cell Microbiol (2011) 1.25
The alternative activation pathway and complement component C3 are critical for a protective immune response against Pseudomonas aeruginosa in a murine model of pneumonia. Infect Immun (2004) 1.21
Efficacy of antimicrobial therapy in experimental rat pneumonia: effects of impaired phagocytosis. Infect Immun (1979) 1.19
Effect of systemic immunization on pulmonary clearance of Haemophilus influenzae type b. Infect Immun (1985) 1.16
Innate immune defense against pneumococcal pneumonia requires pulmonary complement component C3. Infect Immun (2005) 1.14
Murine complement interactions with Pseudomonas aeruginosa and their consequences during pneumonia. Am J Respir Cell Mol Biol (2003) 1.14
A fusion protein vaccine containing OprF epitope 8, OprI, and type A and B flagellins promotes enhanced clearance of nonmucoid Pseudomonas aeruginosa. Infect Immun (2009) 1.12
The effects of PspC on complement-mediated immunity to Streptococcus pneumoniae vary with strain background and capsular serotype. Infect Immun (2009) 1.11
Species-specific interaction of Streptococcus pneumoniae with human complement factor H. J Immunol (2008) 1.08
Dynamics of intrapulmonary bacterial growth in a murine model of repeated microaspiration. Am J Respir Cell Mol Biol (2005) 1.06
Impaired lung defenses against Staphylococcus aureus in mice with hereditary deficiency of the fifth component of complement. Infect Immun (1983) 1.06
Opsonins in normal mouse serum for the phagocytic killing of Proteus mirabilis by murine neutrophils. Br J Exp Pathol (1984) 1.05
Comparative role of complement in pneumococcal and staphylococcal pneumonia. Infect Immun (1982) 1.04
Lung defenses against Pseudomonas aeruginosa in C5-deficient mice with different genetic backgrounds. Infect Immun (1986) 1.01
Klebsiella pneumoniae: Going on the Offense with a Strong Defense. Microbiol Mol Biol Rev (2016) 0.98
Chronic glucocorticosteroid therapy impairs staphylococcal clearance from murine lungs. Infect Immun (1982) 0.96
Effect of C3 depletion on experimental Pseudomonas aeruginosa ocular infection: histopathological analysis. Infect Immun (1984) 0.96
Animal model of neutropenia suitable for the study of dual-phagocyte systems. Infect Immun (1979) 0.90
Early clearance of pneumococci from the lungs of decomplemented rats. Infect Immun (1982) 0.89
Bacillus anthracis interacts with plasmin(ogen) to evade C3b-dependent innate immunity. PLoS One (2011) 0.88
C3 promotes clearance of Klebsiella pneumoniae by A549 epithelial cells. Infect Immun (2004) 0.88
Pulmonary opsonins in Klebsiella pneumoniae pneumonia in rats. Infect Immun (1981) 0.85
Role of complement in chemotaxis: study of a localized infection. Infect Immun (1980) 0.81
Identification of OprF as a complement component C3 binding acceptor molecule on the surface of Pseudomonas aeruginosa. Infect Immun (2015) 0.80
Complement components (C1, C2, C3, C4) in bronchial secretions after intranasal infection of guinea pigs with Mycoplasma pneumoniae: dissociation of unspecific and specific defense mechanisms. Infect Immun (1979) 0.80
The Bordetella pertussis Bps polysaccharide enhances lung colonization by conferring protection from complement-mediated killing. Cell Microbiol (2014) 0.79
Relationships between alternative complement pathway activation, C-reactive protein, and pneumococcal infection. J Clin Microbiol (1986) 0.76
Receptors for complement of leukocytes. J Exp Med (1968) 11.57
Depletion of plasma complement in vivo by a protein of cobra venom: its effect on various immunologic reactions. J Immunol (1970) 6.58
The enhancement of bacterial phagocytosis by serum. The role of complement components and two cofactors. J Exp Med (1969) 4.96
A QUANTITATIVE STUDY OF THE DEPOSITION AND CLEARANCE OF BACTERIA IN THE MURINE LUNG. J Clin Invest (1964) 3.40
Human immunity to Pseudomonas aeruginosa. I. In-vitro interaction of bacteria, polymorphonuclear leukocytes, and serum factors. J Infect Dis (1972) 3.28
Pulmonary alveolar macrophage. Defender against bacterial infection of the lung. J Clin Invest (1974) 3.22
An abnormality of the alternate pathway of complement activation in sickle-cell disease. N Engl J Med (1973) 3.11
Receptors for immunoglobulin and complement on human alveolar macrophages. J Immunol (1975) 2.74
Heat labile opsonins to pneumococcus. II. Involvement of C3 and C5. J Exp Med (1969) 2.38
Isolation of heavy and light chains of immunoglobulin from the surfaces of lymphoid cells. J Immunol (1971) 2.35
Heat labile opsonins to pneumococcus. I. Participation of complement. J Exp Med (1969) 2.24
The effect of Sendai virus infection on bactericidal and transport mechanisms of the murine lung. J Clin Invest (1972) 2.19
Induction of serum Haemophilus influenzae type B capsular antibodies in adult volunteers fed cross-reacting Escherichia coli 075:K100:H5. N Engl J Med (1975) 2.16
Increased susceptibility to infection associated with abnormalities of complement-mediated functions and of the third component of complement (C3). N Engl J Med (1970) 2.08
Chemotaxis of leucocytes and inflammation. Ser Haematol (1970) 2.00
Blood group isoantibody stimulation in man by feeding blood group-active bacteria. J Clin Invest (1969) 1.97
Complete absence of the third component of complement in man. J Clin Invest (1975) 1.75
Protein A from Staphylococcus aureus: the biological significance of its reaction with IgG. Ann N Y Acad Sci (1974) 1.62
Protective role of complement in experimental Escherichia coli endocarditis. Infect Immun (1977) 1.57
Studies in vivo of cobra factor and murine C3. Immunology (1975) 1.49
The role of C3 as an opsonin in the early stages of infection. Proc Soc Exp Biol Med (1975) 1.38
Determinants of lung bacterial clearance in normal mice. J Clin Invest (1976) 1.21
ACUTE EXPERIMENTAL PNEUMOCOCCAL (TYPE I) PNEUMONIA IN THE MOUSE: THE MIGRATION OF LEUCOCYTES FROM THE PULMONARY CAPILLARIES INTO THE ALVEOLAR SPACES AS REVEALED BY THE ELECTRON MICROSCOPE. Trans Am Clin Climatol Assoc (1962) 1.14
Immunologic studies in pneumococcal disease. J Lab Clin Med (1977) 1.12
Inhibition of immune phagocytosis of Diplococcus pneumoniae by human neutrophiles with antibody against complement. J Immunol (1961) 1.11
Exposure chamber for 66 mice suitable for use with the henderson aerosol apparatus. Appl Microbiol (1968) 1.08
Leukocytic response to inhaled bacteria. Am Rev Respir Dis (1977) 1.06
The effect of complement depletion on experimental tissue injury. Ann N Y Acad Sci (1975) 1.06
Serum heat-labile opsonins in systemic lupus erythematosus. J Clin Invest (1974) 0.95
Relationship of functional levels of early components of complement to the H-2 complex of mice. J Immunol (1976) 0.92
Changing pharyngeal bacterial flora of hospitalized patients. Emergence of gram-negative bacilli. N Engl J Med (1969) 5.28
Nosocomial respiratory infections with gram-negative bacilli. The significance of colonization of the respiratory tract. Ann Intern Med (1972) 3.49
Pharyngeal aspiration in normal adults and patients with depressed consciousness. Am J Med (1978) 2.65
Nebulization equipment. A potential source of infection in gram-negative pneumonias. Am J Dis Child (1966) 1.82
Pulmonary clearance of gram-negative bacilli. J Lab Clin Med (1967) 1.78
Long-term evaluation of decontamination of inhalation-therapy equipment and the occurrence of necrotizing pneumonia. N Engl J Med (1970) 1.64
The relationship of inoculum size to lung bacterial clearance and phagocytic cell response in mice. Am Rev Respir Dis (1979) 1.61
Early bacterial clearance from murine lungs. Species-dependent phagocyte response. J Clin Invest (1980) 1.54
Aerobic gram-negative bacillary pneumonias. Am Rev Respir Dis (1974) 1.52
Pneumoconiosis among the activated-carbon workers. Arch Environ Health (1975) 1.43
Pulmonary clearance of Pseudomonas aeruginosa. J Lab Clin Med (1970) 1.40
The radiographic resolution of Streptococcus pneumoniae pneumonia. N Engl J Med (1975) 1.39
Congenital tracheobronchomegaly (Mounier-Kuhn syndrome): a report of 10 cases and review of the literature. J Thorac Imaging (1991) 1.38
Pulmonary function in uncomplicated influenza. Am Rev Respir Dis (1969) 1.33
Effects of fluticasone propionate, triamcinolone acetonide, prednisone, and placebo on the hypothalamic-pituitary-adrenal axis. J Allergy Clin Immunol (1999) 1.28
Intravascular coagulation associated with the adult respiratory distress syndrome. Am J Med (1976) 1.26
Granulocyte-alveolar-macrophage interaction in the pulmonary clearance of Staphylococcus aureus. Am Rev Respir Dis (1983) 1.24
An analysis of factors predisposing to gram-negative bacillary necrotizing pneumonia. Am Rev Respir Dis (1966) 1.23
Pulmonary aspiration of gastric contents. Am Rev Respir Dis (1976) 1.21
Determinants of lung bacterial clearance in normal mice. J Clin Invest (1976) 1.21
Puffing topography as a determinant of smoke exposure. Pharmacol Biochem Behav (1990) 1.20
Effects of elastase, collagenase, and papain on structure and function of rat lungs in vitro. J Clin Invest (1972) 1.14
Controlled oxygen administration in acute respiratory failure in chronic obstructive pulmonary disease: a reappraisal. Am J Med (1978) 1.13
The role of bacterial antagonism in pneumococcal colonization of the human pharynx. J Lab Clin Med (1970) 1.12
Comparison of the anticholinergic bronchodilator ipratropium bromide with metaproterenol in chronic obstructive pulmonary disease. A 90-day multi-center study. Am J Med (1986) 1.10
Bacterial growth in vivo. An important determinant of the pulmonary clearance of Diplococcus pneumoniae in rats. J Clin Invest (1974) 1.09
Exposure chamber for 66 mice suitable for use with the henderson aerosol apparatus. Appl Microbiol (1968) 1.08
Lower levels of vitamin C and carotenes in plasma of cigarette smokers. J Am Coll Nutr (1986) 1.07
Leukocytic response to inhaled bacteria. Am Rev Respir Dis (1977) 1.06
A comparison of effects of triamcinolone acetonide aqueous nasal spray, oral prednisone, and placebo on adrenocortical function in male patients with allergic rhinitis. J Allergy Clin Immunol (1996) 1.05
Pulmonary function measurements in patients with thermal injury and smoke inhalation. Am Rev Respir Dis (1980) 1.03
Acquired tracheomegaly in adults as a complication of diffuse pulmonary fibrosis. AJR Am J Roentgenol (1989) 0.99
Mechanisms of complement-mediated clearance of bacteria from the murine lung. Am Rev Respir Dis (1982) 0.98
Micronutrient status and immune function in smokers. Ann N Y Acad Sci (1990) 0.98
A 12-week dose-ranging study of fluticasone propionate powder in the treatment of asthma. J Asthma (1996) 0.96
Dose-ranging study of a new steroid for asthma: mometasone furoate dry powder inhaler. Respir Med (1999) 0.96
Clearance of Serratia marcescens from Lungs of Normal Mice. Infect Immun (1971) 0.93
Infarcted small bowel appendice epiploica: a cause of acute abdomen. Am J Proctol Gastroenterol Colon Rectal Surg (1981) 0.93
Spontaneous fibrinolysis in pulmonary embolism. J Clin Invest (1971) 0.93
A noninvasive technique for measurement of airway conductance in small animals. J Appl Physiol (1971) 0.93
Comparison of the pulmonary bactericidal capacity of mice and rats aganist strains of Pseudomonas aeruginosa. Appl Microbiol (1971) 0.93
Hypoxemia in pulmonary embolism, a clinical study. J Clin Invest (1971) 0.93
Cardiovascular effects of positive end-expiratory pressure in dogs. J Appl Physiol Respir Environ Exerc Physiol (1978) 0.92
An evaluation of exercise tests in chronic obstructive lung disease. J Appl Physiol (1969) 0.92
The effects of systemic immunization of pulmonary clearance of Pseudomonas aeruginosa. Am Rev Respir Dis (1985) 0.92
Bacterial contamination of aerosols. Arch Intern Med (1973) 0.92
Effects of smoking on inflammatory mediators and their relationship to pulmonary dysfunction. Eur J Respir Dis Suppl (1986) 0.92
Increased salivary elastase precedes gram-negative bacillary colonization in postoperative patients. Am Rev Respir Dis (1987) 0.92
Participation of inhibitory and excitatory interneurones in the control of hippocampal cortical output. UCLA Forum Med Sci (1969) 0.91
Rapid diagnosis of community-acquired bacterial pneumonia. Am Rev Respir Dis (1983) 0.90
Animal model of neutropenia suitable for the study of dual-phagocyte systems. Infect Immun (1979) 0.90
A morphological study of the role of phagocytes in the clearance of Staphylococcus aureus from the lung. J Reticuloendothel Soc (1983) 0.89
Early clearance of pneumococci from the lungs of decomplemented rats. Infect Immun (1982) 0.89
Acute and chronic desensitization of penicillin-allergic patients using oral penicillin. J Allergy Clin Immunol (1987) 0.89
Gram-negative bacillary necrotizing pneumonia: a bacteriologic and histopathologic correlation. J Infect Dis (1969) 0.89
Early pulmonary granulocyte recruitment in response to Streptococcus pneumoniae. Am Rev Respir Dis (1984) 0.89
The evolution of papain emphysema in the rat. J Lab Clin Med (1971) 0.89
Exercise ventilatory patterns in normal subjects and patientws with airway obstruction. J Appl Physiol (1968) 0.87
Connective tissue damage in emphysema. An electron microscopic study of papain-induced emphysema in rats. Am Rev Respir Dis (1973) 0.87
Lung clearance of Staphylococcus aureus strains with differing protein A content: protein A effect on in vivo clearance. Infect Immun (1978) 0.86
Comparison of intratracheal and intravenous inoculation of sheep erythrocytes in the induction of local and systemic immune responses. Infect Immun (1979) 0.86
Extracellular killing of inhaled pneumococci in rats. J Lab Clin Med (1987) 0.86
Comparison of the pulmonary bactericidal capacity of mice and rats against strains of Pseudomonas aeruginosa. Appl Microbiol (1971) 0.85
Area-sampling technique for quantitative pharyngeal cultures. Appl Microbiol (1969) 0.85
Determinants of lung bacterial clearance in mice after acute hypoxia. Am Rev Respir Dis (1977) 0.84
Increased neutrophil myeloperoxidase activity associated with cigarette smoking. Eur J Respir Dis (1985) 0.84
Kitt Peak 60-cm vacuum telescope. Appl Opt (1976) 0.84
Fibronectin is not detectable on the intact buccal epithelial surface of normal rats or humans. Am J Respir Cell Mol Biol (1990) 0.83
Splenic influence on the development of a local pulmonary immune response. Infect Immun (1979) 0.83
Pulmonary clearance and phagocytic cell response to normal pharyngeal flora. Am Rev Respir Dis (1981) 0.82
The effects of triamcinolone acetonide aqueous nasal spray on adrenocortical function in children with allergic rhinitis. J Allergy Clin Immunol (1998) 0.82
The longterm treatment of an asthmatic patient using phentolamine. Chest (1974) 0.82
Complement receptors of rat macrophages. J Reticuloendothel Soc (1982) 0.82
Effect of smoking on peripheral blood leukocytes and serum antiproteases. Eur J Respir Dis Suppl (1985) 0.82
The fifth component of complement is not required for the clearance of Staphylococcus aureus. Am Rev Respir Dis (1984) 0.81
Smoking history, cigarette yield and smoking behavior as determinants of smoke exposure. Eur J Respir Dis Suppl (1986) 0.81
Respiratory complications of overdose with sedative drugs. Am Rev Respir Dis (1975) 0.81
Scientific bases of in-hospital respiratory therapy introduction. Am Rev Respir Dis (1980) 0.81
Lung structure and function with age in normal rats and rats with papain emphysema. J Clin Invest (1973) 0.80
Pulmonary elastase activity in response to Streptococcus pneumoniae and Pseudomonas aeruginosa. Am Rev Respir Dis (1985) 0.80
Cleaning and sterilization of inhalation equipment. A statement by the committee on therapy. Am Rev Respir Dis (1968) 0.80
Studies of a new humidifying device as a potential source of bacterial aerosols. Am Rev Respir Dis (1967) 0.80
Lung uptake of Tc-99m HMPAO in cigarette smokers expressed by lung/liver activity ratio. Clin Nucl Med (1993) 0.79
Pulmonary function in Bagasse worker's lung disease. Am Rev Respir Dis (1968) 0.79
Population characteristics and cigarette yield as determinants of smoke exposure. Pharmacol Biochem Behav (1990) 0.79
Pulmonary complications of general surgery. Annu Rev Med (1977) 0.79
Miliary pulmonary blastomycosis. Radiology (1984) 0.78
Respiratory function during sleep in patients with chronic obstructive lung disease. J Clin Invest (1966) 0.78
Fatal asthma after ingestion of sulfite-containing wine. Ann Intern Med (1987) 0.77
Asthma symptoms and airway hyperresponsiveness are lower during treatment with nedocromil sodium than during treatment with regular inhaled albuterol. J Allergy Clin Immunol (1995) 0.76
Rampant empiricism. Am J Med (1990) 0.75
Nosocomial pneumonia in patients in intensive care units. West J Med (1985) 0.75