Engineered T cells: the promise and challenges of cancer immunotherapy.

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🔗 View Article (PMID 27550819)

Published in Nat Rev Cancer on August 23, 2016

Authors

Andrew D Fesnak1, Carl H June1, Bruce L Levine1

Author Affiliations

1: Department of Pathology and Laboratory Medicine and Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-5156, USA.

Associated clinical trials:

CD19-specific T Cell Infusion in Patients With B-Lineage Lymphoid Malignancies | NCT00968760

In Vitro Expanded Allogeneic Epstein-Barr Virus Specific Cytotoxic T-Lymphocytes (EBV-CTLs) Genetically Targeted to the CD19 Antigen in B-cell Malignancies | NCT01430390

3rd Generation GD-2 Chimeric Antigen Receptor and iCaspase Suicide Safety Switch, Neuroblastoma, GRAIN (GRAIN) | NCT01822652

CD19 CAR T Cells for B Cell Malignancies After Allogeneic Transplant | NCT01475058

Adoptive Transfer of Autologous T Cells Targeted to Prostate Specific Membrane Antigen (PSMA) for the Treatment of Castrate Metastatic Prostate Cancer (CMPC) | NCT01140373

High Dose Therapy and Autologous Stem Cell Transplantation Followed by Infusion of Chimeric Antigen Receptor (CAR) Modified T-Cells Directed Against CD19+ B-Cells for Relapsed and Refractory Aggressive B Cell Non-Hodgkin Lymphoma | NCT01840566

T-Lymphocytes Genetically Targeted to the B-Cell Specific Antigen CD19 in Pediatric and Young Adult Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia | NCT01860937

Activated T-Cells Expressing 2nd or 3rd Generation CD19-Specific CAR, Advanced B-Cell NHL, ALL, and CLL (SAGAN) (SAGAN) | NCT01853631

Pilot Study of Autologous T Cells Redirected to EGFRVIII-With a Chimeric Antigen Receptor in Patients With EGFRVIII+ Glioblastoma | NCT02209376

A Pediatric Trial of Genetically Modified Autologous T Cells Directed Against CD19 for Relapsed CD19+ Acute Lymphoblastic Leukemia | NCT01683279

A Phase I Trial of T Cells Expressing an Anti-GD2 Chimeric Antigen Receptor in Children and Young Adults With GD2+ Solid Tumors | NCT02107963

Safety Study of Anti LewisY Chimeric Antigen Receptor in Myeloma, Acute Myeloid Leukemia or Myelodysplastic Syndrome | NCT01716364

Re-directed T Cells for the Treatment (FAP)-Positive Malignant Pleural Mesothelioma | NCT01722149

Phase II/Pilot Study of 2nd Generation Anti-CEA Designer T Cells in Adenocarcinomas | NCT01723306

A Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD19 for Relapsed/Refractory CD19+ Leukemia | NCT02028455

Autologous Redirected RNA Meso CAR T Cells for Pancreatic Cancer | NCT01897415

CD19 Redirected Autologous T Cells | NCT01747486

Study of T Cells Targeting B-Cell Maturation Antigen for Previously Treated Multiple Myeloma | NCT02215967

CART-meso in Mesothelin Expressing Cancers | NCT02159716

Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma | NCT02208362

Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia | NCT02159495

Phase I/II Study to Assess the Safety and Activity of Enhanced TCR Transduced Autologous T Cells in Metastatic Melanoma | NCT01350401

T Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated Cancers | NCT02280811

T Cell Receptor Immunotherapy Targeting NY-ESO-1 for Patients With NY-ESO-1 Expressing Cancer | NCT01967823

Anti-CD22 Chimeric Receptor T Cells in Pediatric and Young Adults With Recurrent or Refractory CD22-expressing B Cell Malignancies | NCT02315612

Gene and Vaccine Therapy in Treating Patients With Advanced Malignancies | NCT01697527

Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin | NCT02414269

Study of Redirected Autologous T Cells Engineered to Contain Anti-CD19 Attached to TCR and 4-1BB Signaling Domains in Patients With Chemotherapy Resistant or Refractory Acute Lymphoblastic Leukemia | NCT02030847

Activated T Lymphocytes Expressing CARs, Relapsed CD19+ Malignancies Post-Allo HSCT(CARPASCIO) (CARPASCIO) | NCT02050347

WT1 TCR Gene Therapy for Leukaemia: A Phase I/II Safety and Toxicity Study | NCT01621724

Safety Study of Chimeric Antigen Receptor Modified T-cells Targeting NKG2D-Ligands | NCT02203825

A Clinical Research of CAR T Cells Targeting CEA Positive Cancer | NCT02349724

Laboratory-Treated T Cells in Treating Patients With High-Risk Relapsed Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia Previously Treated With Donor Stem Cell Transplant | NCT01640301

cMet CAR RNA T Cells Targeting Breast Cancer | NCT01837602

Gene-Modified T Cells, Vaccine Therapy, and Ipilimumab in Treating Patients With Locally Advanced or Metastatic Malignancies | NCT02070406

Cyclophosphamide Followed by Intravenous and Intraperitoneal Infusion of Autologous T Cells Genetically Engineered to Secrete IL-12 and to Target the MUC16ecto Antigen in Patients With Recurrent MUC16ecto+ Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer | NCT02498912

CT Antigen TCR-Engineered T Cells for Myeloma | NCT01892293

CD19-targeting 3rd Generation CAR T Cells for Refractory B Cell Malignancy - a Phase I/IIa Trial. | NCT02132624

Pilot Study of Autologous T-cells in Patients With Metastatic Pancreatic Cancer | NCT02465983

CD19 Redirected Autologous T Cells for Hodgkin Lymphoma | NCT02277522

T Cell Receptor Immunotherapy Targeting MAGE-A3 for Patients With Metastatic Cancer Who Are HLA-DP0401 Positive | NCT02111850

Cellular Immunotherapy in Treating Patients With High-Risk Acute Lymphoblastic Leukemia | NCT02146924

Phase IIa Study of Redirected Autologous T Cells Engineered to Contain Anti-CD19 Attached to TCRz and 4-Signaling Domains in Patients With Chemotherapy Relapsed or Refractory CD19+ Lymphomas | NCT02030834

CAR T Cells in Treating Patients With Malignant Gliomas Overexpressing EGFR | NCT02331693

CART-19 Immunotherapy in Mantle Cell Lymphoma | NCT02081937

T Cell Receptor Immunotherapy Targeting MAGE-A3 for Patients With Metastatic Cancer Who Are HLA-A*01 Positive | NCT02153905

CD123 Redirected Autologous T Cells for AML | NCT02623582

Anti-GPC3 CAR T for Treating Patients With Advanced HCC | NCT02395250

Transfer of Genetically Engineered Lymphocytes in Melanoma Patients | NCT01586403

CD30-directed Chimeric Antigen Receptor T (CART30) Therapy in Relapsed and Refractory CD30 Positive Lymphomas (CART30) | NCT02259556

Investigator Initiated Phase 1 Study of TBI-1201 | NCT02096614

A Phase 1-2 Multi-Center Study Evaluating KTE-C19 in Subjects With Refractory Aggressive Non-Hodgkin Lymphoma (ZUMA-1) (ZUMA-1) | NCT02348216

CART-BCMA Cells for Multiple Myeloma | NCT02546167

Evaluation of 4th Generation Safety-designed CAR T Cells Targeting High-risk and Refractory B Cell Lymphomas (4SCAR19273) | NCT02247609

Gene Therapy for B-Cell Non-Hodgkin Lymphoma Using CD19 CAR Gene Transduced T Lymphocytes | NCT02134262

A Phase I Study of CD19 Specific T Cells in CD19 Positive Malignancy (CD19) | NCT01493453

CAR-T Cell Immunotherapy in MUC1 Positive Solid Tumor | NCT02617134

Genetically Modified T Cells in Treating Patients With Stage III-IV Non-small Cell Lung Cancer or Mesothelioma | NCT02408016

T Cell Receptor-transduced T Cells Targeting NY-ESO-1 for Treatment of Patients With NY-ESO-1- Expressing Malignancies | NCT02457650

CAR T Cells Targeting CD30 Positive Lymphomas (4SCAR30273) | NCT02274584

Pilot Study of Autologous Anti-CD22 Chimeric Antigen Receptor Redirected T Cells In Patients With Chemotherapy Resistant Or Refractory Acute Lymphoblastic Leukemia | NCT02588456

Evaluation of CAR19 T-cells as an Optimal Bridge to Allogeneic Transplantation (COBALT) | NCT02431988

Study of Efficacy and Safety of CTL019 in Pediatric ALL Patients | NCT02228096

Investigator Initiated Phase 1 Study of TBI-1301 | NCT02366546

Treatment of Relapsed and/or Chemotherapy Refractory Advanced Malignancies by CART-meso | NCT02580747

Pilot Study of Non-Viral, RNA-Redirected Autologous T Cells in Patients With Refractory or Relapsed Hodgkin Lymphoma | NCT02624258

Study of Efficacy and Safety of CTL019 in Adult DLBCL Patients (JULIET) | NCT02445248

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing Human Thyroglobulin to People With Thyroglobulin Expressing Thyroid Cancer | NCT02390739

A Clinical Research of CAR T Cells Targeting CD19 Positive Malignant B-cell Derived Leukemia and Lymphoma | NCT02349698

Phase I/II Study of Anti-Mucin1 (MUC1) CAR T Cells for Patients With MUC1+ Advanced Refractory Solid Tumor | NCT02587689

Immunotherapy With CD19 CAR T-cells for B-Cell Lymphoma, ALL and CLL | NCT02546739

Study of Pembrolizumab in Patients Failing to Respond to or Relapsing After Anti-CD19 Chimeric Antigen Receptor Modified T Cell Therapy for Relapsed or Refractory CD19+ Lymphomas | NCT02650999

CD19-directed CAR T Cells Therapy in Relapsed/Refractory B Cell Malignancy | NCT02537977

A Multi-Center Study Evaluating KTE-C19 in Pediatric and Adolescent Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (ZUMA-4) | NCT02625480

Study Evaluating the Efficacy and Safety of JCAR015 in Adult B-cell Acute Lymphoblastic Leukemia (B-ALL) (ROCKET) | NCT02535364

A Study Evaluating KTE-C19 in Adult Subjects With Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia (r/r ALL) (ZUMA-3) (ZUMA-3) | NCT02614066

Study Evaluating the Safety and Pharmacokinetics of JCAR017 in B-cell Non-Hodgkin Lymphoma (NHL) | NCT02631044

A Phase I/II Study of Gene-modified WT1 TCR Therapy in MDS & AML Patients | NCT02550535

Study With T-cel Receptor Gene Therapy in Metastatic Melanoma (TCR) | NCT02654821

CD19+ CAR T Cells for Lymphoid Malignancies | NCT02529813

Anti-CD19 Chimeric Antigen Receptor (CAR)-Transduced T Cell Therapy for Patients With B Cell Malignancies | NCT02456350

Determine Efficacy and Safety of CTL019 in Pediatric Patients With Relapsed and Refractory B-cell ALL (ELIANA) | NCT02435849

CARPALL: Immunotherapy With CD19 CAR T-cells for CD19+ Haematological Malignancies | NCT02443831

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