ZEB1-mediated melanoma cell plasticity enhances resistance to MAPK inhibitors.

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Published in EMBO Mol Med on October 04, 2016

Authors

Geoffrey Richard1, Stéphane Dalle2, Marie-Ambre Monet1, Maud Ligier1, Amélie Boespflug2, Roxane M Pommier1, Arnaud de la Fouchardière3, Marie Perier-Muzet2, Lauriane Depaepe4, Romain Barnault1, Garance Tondeur4, Stéphane Ansieau1, Emilie Thomas5, Corine Bertolotto6, Robert Ballotti6, Samia Mourah7, Maxime Battistella8, Céleste Lebbé9, Luc Thomas2, Alain Puisieux10, Julie Caramel11

Author Affiliations

1: Cancer Research Center of Lyon, INSERM U1052, Lyon, France Cancer Research Center of Lyon, CNRS UMR 5286, Lyon, France Université de Lyon, Lyon, France ISPB Université Lyon 1, Lyon, France Centre Léon Bérard, Lyon, France.
2: Cancer Research Center of Lyon, INSERM U1052, Lyon, France Cancer Research Center of Lyon, CNRS UMR 5286, Lyon, France Université de Lyon, Lyon, France ISPB Université Lyon 1, Lyon, France Centre Léon Bérard, Lyon, France Dermatology Unit, Hospices Civils de Lyon CH Lyon Sud, Pierre Bénite Cedex, France.
3: Cancer Research Center of Lyon, INSERM U1052, Lyon, France Cancer Research Center of Lyon, CNRS UMR 5286, Lyon, France Université de Lyon, Lyon, France ISPB Université Lyon 1, Lyon, France Centre Léon Bérard, Lyon, France Department of Biopathology, Centre Léon Bérard, Lyon, France.
4: Department of Biopathology, Hospices Civils de Lyon CH Lyon Sud, Pierre-Bénite Cedex, France.
5: Fondation Synergie Lyon Cancer, Centre Léon Bérard, Lyon, France.
6: INSERM U1065 Equipe 1 Biologie et pathologies des mélanocytes: de la pigmentation cutanée au mélanome Equipe labellisée Ligue 2013 Centre Méditerranéen de Médecine Moléculaire, Nice, France Université de Nice Sophia-Antipolis UFR Médecine, Nice, France CHU Nice Service de Dermatologie, Nice, France.
7: APHP INSERM U976 Saint Louis Hospital Pharmacology-Genetic Laboratory Paris, Paris, France.
8: Department of Pathology, INSERM U1165 Université Paris Diderot AP-HP Hôpital Saint-Louis, Paris, France.
9: Department of Dermatology, APHP Saint Louis Hospital, Paris, France INSERM U976 University Paris 7 Diderot, Paris, France.
10: Cancer Research Center of Lyon, INSERM U1052, Lyon, France Cancer Research Center of Lyon, CNRS UMR 5286, Lyon, France Université de Lyon, Lyon, France ISPB Université Lyon 1, Lyon, France Centre Léon Bérard, Lyon, France Institut Universitaire de France, Paris, France alain.puisieux@lyon.unicancer.fr julie.caramel@lyon.unicancer.fr.
11: Cancer Research Center of Lyon, INSERM U1052, Lyon, France Cancer Research Center of Lyon, CNRS UMR 5286, Lyon, France Université de Lyon, Lyon, France ISPB Université Lyon 1, Lyon, France Centre Léon Bérard, Lyon, France alain.puisieux@lyon.unicancer.fr julie.caramel@lyon.unicancer.fr.

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