Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 27618837)

Published in Gut on September 12, 2016

Authors

Pietro Carotenuto1, Matteo Fassan2,3, Rosantony Pandolfo1, Andrea Lampis1, Caterina Vicentini3, Luciano Cascione4, Viola Paulus-Hock5, Luke Boulter6, Rachel Guest7, Luca Quagliata8, Jens Claus Hahne1, Rachel Ridgway9, Tam Jamieson9, Dimitris Athineos9, Angelo Veronese10, Rosa Visone10, Claudio Murgia9, Giulia Ferrari1, Vincenza Guzzardo2, Thomas Ronald Jeffry Evans5, Martin MacLeod5, Gui Ji Feng11, Trevor Dale11, Massimo Negrini12, Stuart J Forbes7, Luigi Terracciano8, Aldo Scarpa3, Tushar Patel13, Nicola Valeri1,14, Paul Workman1, Owen Sansom9, Chiara Braconi15

Author Affiliations

1: The Institute of Cancer Research, London, UK.
2: Department of Medicine, University of Padua, Padua, Italy.
3: ARC-NET Research Centre, University of Verona, Verona, Italy.
4: Institute of Oncology Research, Bellinzona, Switzerland.
5: Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
6: MRC Human Genetics Unit, University of Edinburgh, Edinburgh, UK.
7: MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
8: Molecular Pathology Division, Institute of Pathology, University of Basel, Basel, Switzerland.
9: Cancer Research UK Beatson Institute for Cancer Research, Glasgow, UK.
10: Department of Medical, Oral and Biotechnological Sciences, G. d'Annunzio University, Chieti, Italy.
11: School of Biosciences, Cardiff University, Cardiff, UK.
12: University of Ferrara, Ferrara, Italy.
13: Mayo Clinic, Jacksonville, Florida, USA.
14: The Royal Marsden NHS Foundation Trust, London and Surrey, UK.
15: The Institute of Cancer Research, London, UK The Royal Marsden NHS Foundation Trust, London and Surrey, UK.

Articles citing this

LncRNA-mediated regulation of cell signaling in cancer. Oncogene (2017) 0.75

Articles cited by this

Sorafenib in advanced hepatocellular carcinoma. N Engl J Med (2008) 54.30

Ultraconserved elements in the human genome. Science (2004) 17.14

EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol (2012) 16.93

MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology (2007) 13.20

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat Genet (2012) 6.65

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66

Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell (2007) 5.40

microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. Oncogene (2011) 3.02

Genome-wide analysis of long noncoding RNA stability. Genome Res (2012) 2.49

Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene (2002) 2.16

High alpha-fetoprotein level correlates with high stage, early recurrence and poor prognosis of hepatocellular carcinoma: significance of hepatitis virus infection, age, p53 and beta-catenin mutations. Int J Cancer (2004) 1.95

Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma. Proc Natl Acad Sci U S A (2010) 1.87

WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. J Clin Invest (2015) 1.68

Regulation of pri-miRNA processing by a long noncoding RNA transcribed from an ultraconserved region. Mol Cell (2014) 1.68

CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer. Oncogene (2010) 1.65

MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell (2014) 1.59

siRNA-mediated beta-catenin knockdown in human hepatoma cells results in decreased growth and survival. Neoplasia (2007) 1.51

Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling. Hepatology (2012) 1.50

Complete response of Ctnnb1-mutated tumours to β-catenin suppression by locked nucleic acid antisense in a mouse hepatocarcinogenesis model. J Hepatol (2014) 1.50

MicroRNA-26a promotes cholangiocarcinoma growth by activating β-catenin. Gastroenterology (2012) 1.48

Extracellular Vesicle-Mediated Transfer of a Novel Long Noncoding RNA TUC339: A Mechanism of Intercellular Signaling in Human Hepatocellular Cancer. Genes Cancer (2013) 1.47

The Landscape of long noncoding RNA classification. Trends Genet (2015) 1.47

Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib. Clin Cancer Res (2012) 1.44

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours. Oncogene (2010) 1.43

MicroRNA-193b regulates proliferation, migration and invasion in human hepatocellular carcinoma cells. Eur J Cancer (2010) 1.37

The role of microRNAs in human liver cancers. Semin Oncol (2011) 1.34

lncRNAs and microRNAs with a role in cancer development. Biochim Biophys Acta (2015) 1.32

Altered expression of beta-catenin without genetic mutation in intrahepatic cholangiocarcinoma. Mod Pathol (2001) 1.27

β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis. Gastroenterology (2015) 1.20

Hepatitis C virus proteins modulate microRNA expression and chemosensitivity in malignant hepatocytes. Clin Cancer Res (2010) 1.17

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet (2010) 1.16

Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma. Cell Biosci (2011) 1.16

Targeting Wnt pathways in disease. Cold Spring Harb Perspect Biol (2012) 1.11

Plasticity of hepatic cell differentiation: bipotential adult mouse liver clonal cell lines competent to differentiate in vitro and in vivo. Stem Cells (2006) 1.11

Mutated beta-catenin evades a microRNA-dependent regulatory loop. Proc Natl Acad Sci U S A (2011) 1.08

Wnt/β-Catenin activates MiR-183/96/182 expression in hepatocellular carcinoma that promotes cell invasion. Cancer Lett (2015) 1.04

Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer. Mol Cancer (2013) 1.01

Non-coding RNAs as therapeutic targets in hepatocellular cancer. Curr Cancer Drug Targets (2012) 0.96

Restoration of miR-193b sensitizes Hepatitis B virus-associated hepatocellular carcinoma to sorafenib. Cancer Lett (2014) 0.93

MiR-612 suppresses the stemness of liver cancer via Wnt/β-catenin signaling. Biochem Biophys Res Commun (2014) 0.92

Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway. Hepatology (2013) 0.91

Non-Coding RNAs in Primary Liver Cancer. Front Med (Lausanne) (2015) 0.85

Downregulation of miR-610 promotes proliferation and tumorigenicity and activates Wnt/β-catenin signaling in human hepatocellular carcinoma. Mol Cancer (2014) 0.84

Conditional disruption of Axin1 leads to development of liver tumors in mice. Gastroenterology (2012) 0.84

Transcribed ultraconserved noncoding RNAs (T-UCR) are involved in Barrett's esophagus carcinogenesis. Oncotarget (2014) 0.84

Evidence of cell-fate conversion from hepatocytes to cholangiocytes in the injured liver: in-vivo genetic lineage-tracing approaches. Curr Opin Gastroenterol (2015) 0.76