TARP vaccination is associated with slowing in PSA velocity and decreasing tumor growth rates in patients with Stage D0 prostate cancer.

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Published in Oncoimmunology on July 01, 2016

Authors

Lauren V Wood1, Antonio Fojo2, Brenda D Roberson1, Meghan S B Hughes1, William Dahut2, James L Gulley2, Ravi A Madan2, Philip M Arlen2, Marianna Sabatino3, David F Stroncek3, Luciano Castiello3, Jane B Trepel4, Min-Jung Lee4, Howard L Parnes5, Seth M Steinberg6, Masaki Terabe1, Julia Wilkerson2, Ira Pastan7, Jay A Berzofsky1

Author Affiliations

1: Vaccine Branch, Center for Cancer Research, NCI , Bethesda, MD, USA.
2: Genitourinary Malignancies Branch, Center for Cancer Research, NCI , Bethesda, MD, USA.
3: Cell Processing Section, Department of Transfusion Medicine, NIH Clinical Center , Bethesda, MD, USA.
4: Developmental Therapeutics Branch, Center for Cancer Research, NCI , Bethesda, MD, USA.
5: Division of Cancer Prevention, NCI , Bethesda, MD, USA.
6: Biostatistics and Data Management Section, Center for Cancer Research, NCI , Bethesda, MD, USA.
7: Laboratory of Molecular Biology, Center for Cancer Research, NCI , Bethesda, MD, USA.

Associated clinical trials:

A Pilot Study of Vaccination With Epitope-Enhanced TARP Peptide and TARP Peptide-Pulsed Dendritic Cells in the Treatment of Stage D0 Prostate Cancer | NCT00972309

Multi-Epitope TARP Peptide Autologous Dendritic Cell Vaccination in Men With Stage D0 Prostate Cancer | NCT02362451

NCT00694555

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