Thymoquinone mitigate ischemia-reperfusion-induced liver injury in rats: a pivotal role of nitric oxide signaling pathway.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27717985)

Published in Naunyn Schmiedebergs Arch Pharmacol on October 07, 2016

Authors

Mohamed Abd-Elbaset1, El-Shaimaa A Arafa2,3, Gamal A El Sherbiny4, Mohamed S Abdel-Bakky5,6, Abdel Nasser A M Elgendy7

Author Affiliations

1: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt.
2: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt. elshimaa.arafa@pharm.bsu.edu.eg.
3: Department of Pharmacology and Toxicology, College of Pharmacy and Health Sciences, Ajman University of Science and Technology, Ajman, United Arab Emirates. elshimaa.arafa@pharm.bsu.edu.eg.
4: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kafr El-Sheikh University, Kafr El-Sheikh, Egypt.
5: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
6: Department of Pharmacology, College of pharmacy, Al Jouf University, Al Jouf, Kingdom of Saudi Arabia.
7: Department of Pharmacology, Faculty of Veterinary medicine, Beni-Suef University, Beni-Suef, 62514, Egypt.

Articles cited by this

Improved method for the determination of blood glutathione. J Lab Clin Med (1963) 13.04

Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem (1978) 6.79

A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide (2001) 6.48

Intravenous N-acetylcystine: the treatment of choice for paracetamol poisoning. Br Med J (1979) 6.45

Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology (1984) 6.17

Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning. Am J Physiol Gastrointest Liver Physiol (2003) 3.66

Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci (2003) 3.62

Factors in the pathophysiology of the liver ischemia-reperfusion injury. J Surg Res (2007) 1.89

Thymoquinone: a promising anti-cancer drug from natural sources. Int J Biochem Cell Biol (2005) 1.67

Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection. Pharmacol Res (2000) 1.37

Mechanisms of reperfusion injury. Am J Med Sci (1994) 1.29

Isoniazid- and rifampicin-induced oxidative hepatic injury--protection by N-acetylcysteine. Hum Exp Toxicol (2000) 1.24

Gastroprotective activity of Nigella sativa oil and its constituent, thymoquinone, against gastric mucosal injury induced by ischaemia/reperfusion in rats. J Ethnopharmacol (2003) 1.24

Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. Life Sci (2003) 1.13

NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A (2002) 1.10

Nitric oxide, a biological double-faced janus--is this good or bad? Histol Histopathol (2006) 1.09

Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus. Eur J Pharmacol (2006) 1.07

N-acetylcysteine attenuates TNF-alpha-induced human vascular endothelial cell apoptosis and restores eNOS expression. Eur J Pharmacol (2006) 1.07

Oxidative damage in the liver induced by ischemia-reperfusion: protection by melatonin. Hepatogastroenterology (1997) 1.05

Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages. Int Immunopharmacol (2002) 1.04

Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN. Mol Biol Cell (2006) 1.03

Nitric oxide in liver transplantation: pathobiology and clinical implications. Liver Transpl (2003) 1.01

Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver. World J Gastroenterol (2008) 1.00

Thymoquinone triggers anti-apoptotic signaling targeting death ligand and apoptotic regulators in a model of hepatic ischemia reperfusion injury. Drug Discov Ther (2009) 0.96

Protective effect of resveratrol against oxidative stress in cholestasis. J Surg Res (2005) 0.92

NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS. J Cell Sci (2005) 0.91

Effect of simvastatin on nitric oxide synthases (eNOS, iNOS) and arginine and its derivatives (ADMA, SDMA) in ischemia/reperfusion injury in rat liver. Pharmacol Rep (2010) 0.89

N-acetylcysteine inhibits in vivo nitric oxide production by inducible nitric oxide synthase. Nitric Oxide (2001) 0.87

The efficacy of N-acetylcysteine as a hepatoprotective agent in liver transplantation. Transpl Int (1998) 0.86

Increased gene and protein expression of the novel eNOS regulatory protein NOSTRIN and a variant in alcoholic hepatitis. Gastroenterology (2006) 0.86

The effects of curcumin on the liver and remote organs after hepatic ischemia reperfusion injury formed with Pringle manoeuvre in rats. Eur Rev Med Pharmacol Sci (2013) 0.79

Evaluation of protective effect of N-acetyl cysteine on arsenic-induced hepatotoxicity. J Nat Sci Biol Med (2013) 0.78

Attenuation of oxidative stress-induced vascular endothelial dysfunction by thymoquinone. Exp Biol Med (Maywood) (2012) 0.78