Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck.

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Published in N Engl J Med on October 08, 2016

Authors

Robert L Ferris1, George Blumenschein1, Jerome Fayette1, Joel Guigay1, A Dimitrios Colevas1, Lisa Licitra1, Kevin Harrington1, Stefan Kasper1, Everett E Vokes1, Caroline Even1, Francis Worden1, Nabil F Saba1, Lara C Iglesias Docampo1, Robert Haddad1, Tamara Rordorf1, Naomi Kiyota1, Makoto Tahara1, Manish Monga1, Mark Lynch1, William J Geese1, Justin Kopit1, James W Shaw1, Maura L Gillison1

Author Affiliations

1: From the University of Pittsburgh Medical Center and Cancer Institute, Pittsburgh (R.L.F.); the Department of Thoracic-Head and Neck Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston (G.B.); Centre Leon Berard, Lyon (J.F.), Centre Antoine Lacassagne, Nice (J.G.), and Institut Gustave Roussy, Villejuif (C.E.) - all in France; Stanford Cancer Institute, Stanford, CA (A.D.C.); Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milan (L.L.); Institute of Cancer Research-Royal Marsden National Institute for Health Research Biomedical Research Centre, London (K.H.); University Hospital Essen, Essen, Germany (S.K.); University of Chicago, Chicago (E.E.V.); University of Michigan, Ann Arbor (F.W.); Winship Cancer Institute of Emory University, Atlanta (N.F.S.); Hospital Universitario 12 de Octubre, Madrid (L.C.I.D.); Dana-Farber Cancer Institute, Boston (R.H.); Universitätsspital Zurich, Zurich, Switzerland (T.R.); Kobe University Hospital, Kobe (N.K.), and National Cancer Center Hospital East, Kashiwa (M.T.) - both in Japan; Bristol-Myers Squibb, Princeton, NJ (M.M., M.L., W.J.G., J.K., J.W.S.); and Ohio State University, Columbus (M.L.G.).

Associated clinical trials:

Trial of Nivolumab vs Therapy of Investigator's Choice in Recurrent or Metastatic Head and Neck Carcinoma (CheckMate 141) | NCT02105636

Concomitant Immune Check Point Inhibitor With Radiochemotherapy in Head And Neck Cancer | NCT03532737

Phase II Trial of Neoadjuvant and Adjuvant Anti-PD-1 Antibody Toripalimab Combined With CCRT in NPC Patients | NCT03925090

1922GCCC: Pembro and Bavituximab for Squamous Cell Carcinoma of Head and Neck | NCT04150900

Toripalimab for Local-regional Recurrent Nasopharyngeal Carcinoma | NCT04376866

A Phase II Study of Nivolumab in Patients With Genetic Alterations in DNA Damage Repair and Response Who Progressed After Standard Treatment for Metastatic Solid Cancers | NCT04761744

Concurrent Chemoradiotherapy With Toripalimab for Local-regional Recurrent Nasopharyngeal Carcinoma: a Prospective, Single-arm, Phase II Trial | NCT04992988

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