Published in J Chem Inf Model on October 21, 2016
Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med (2011) 13.18
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
Novel procedure for modeling ligand/receptor induced fit effects. J Med Chem (2006) 4.74
Temporal dynamics of the human vaginal microbiota. Sci Transl Med (2012) 4.58
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35
Utilization and outcomes of minimally invasive radical prostatectomy. J Clin Oncol (2008) 4.23
Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81
Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL. Lancet Neurol (2008) 3.41
Reactivation of retinopathy of prematurity after bevacizumab injection. Arch Ophthalmol (2012) 3.25
Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nat Genet (2012) 3.20
Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors. Nat Neurosci (2005) 3.17
Dysregulated pH: a perfect storm for cancer progression. Nat Rev Cancer (2011) 3.10
Gonadotropin-releasing hormone agonists and fracture risk: a claims-based cohort study of men with nonmetastatic prostate cancer. J Clin Oncol (2005) 2.87
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab (2010) 2.77
Prediction and assignment of function for a divergent N-succinyl amino acid racemase. Nat Chem Biol (2007) 2.29
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers. Am J Hum Genet (2013) 2.24
Marine cloud brightening. Philos Trans A Math Phys Eng Sci (2012) 2.23
Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: A 24-week, randomized, double-blind study. Clin Ther (2010) 2.19
Early diagnosis of novel SFTS bunyavirus infection by quantitative real-time RT-PCR assay. J Clin Virol (2011) 2.19
Molecular dynamics simulations of the 136 unique tetranucleotide sequences of DNA oligonucleotides. I. Research design and results on d(CpG) steps. Biophys J (2004) 2.17
Hypothesis testing and power calculations for taxonomic-based human microbiome data. PLoS One (2012) 2.15
Toward better refinement of comparative models: predicting loops in inexact environments. Proteins (2008) 2.06
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes. Proc Natl Acad Sci U S A (2010) 2.06
Assessment of protein structure refinement in CASP9. Proteins (2011) 2.06
Moving beyond rules: the development of a central nervous system multiparameter optimization (CNS MPO) approach to enable alignment of druglike properties. ACS Chem Neurosci (2010) 2.06
Investigation of resistive switching in Cu-doped HfO2 thin film for multilevel non-volatile memory applications. Nanotechnology (2009) 2.06
Outcome of a workshop on applications of protein models in biomedical research. Structure (2009) 2.05
A kinematic view of loop closure. J Comput Chem (2004) 2.03
Membrane trafficking of G protein-coupled receptors. Annu Rev Pharmacol Toxicol (2004) 1.94
Discovery of a dipeptide epimerase enzymatic function guided by homology modeling and virtual screening. Structure (2008) 1.91
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet (2013) 1.88
The Enzyme Function Initiative. Biochemistry (2011) 1.87
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. Nat Chem Biol (2011) 1.82
19p13.1 is a triple-negative-specific breast cancer susceptibility locus. Cancer Res (2012) 1.81
CCG-1423: a small-molecule inhibitor of RhoA transcriptional signaling. Mol Cancer Ther (2007) 1.80
Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers. J Am Chem Soc (2006) 1.79
Proof of concept of microbiome-metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants. PLoS One (2012) 1.74
Structural basis of the recognition of a methylated histone tail by JMJD2A. Proc Natl Acad Sci U S A (2007) 1.74
Pathogenesis of emerging severe fever with thrombocytopenia syndrome virus in C57/BL6 mouse model. Proc Natl Acad Sci U S A (2012) 1.71
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab (2013) 1.70
Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes. ACS Chem Neurosci (2010) 1.66
Natural history of bone complications in men with prostate carcinoma initiating androgen deprivation therapy. Cancer (2004) 1.64
Virtual screening against highly charged active sites: identifying substrates of alpha-beta barrel enzymes. Biochemistry (2005) 1.62
Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome. J Infect Dis (2012) 1.62
Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding. J Cell Biol (2008) 1.61
Medicago truncatula mutants demonstrate the role of plant calcium oxalate crystals as an effective defense against chewing insects. Plant Physiol (2006) 1.57
Rescoring docking hit lists for model cavity sites: predictions and experimental testing. J Mol Biol (2008) 1.57
Prognostic significance of HER2 expression based on trastuzumab for gastric cancer (ToGA) criteria in gastric cancer: an updated meta-analysis. Tumour Biol (2014) 1.56
Clinical manifestation and management of primary malignant tumors of the cervical trachea. Eur Arch Otorhinolaryngol (2013) 1.53
Assessment of the protein-structure refinement category in CASP8. Proteins (2009) 1.53
Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: successful in silico prediction of the relative permeabilities of cyclic peptides. J Am Chem Soc (2006) 1.52
A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. Hum Mol Genet (2013) 1.52
Assessment of four DNA fragments (COI, 16S rDNA, ITS2, 12S rDNA) for species identification of the Ixodida (Acari: Ixodida). Parasit Vectors (2014) 1.51
ERCC2/XPD Lys751Gln and Asp312Asn gene polymorphism and lung cancer risk: a meta-analysis involving 22 case-control studies. J Thorac Oncol (2010) 1.51
CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression. Cancer Res (2013) 1.48
The effect of concomitant prolapse repair on sling outcomes. J Urol (2008) 1.47
Intracellular pH sensors: design principles and functional significance. Physiology (Bethesda) (2007) 1.46
Discovery of new enzymes and metabolic pathways by using structure and genome context. Nature (2013) 1.46
Quantifying Correlations Between Allosteric Sites in Thermodynamic Ensembles. J Chem Theory Comput (2009) 1.45
Computer-aided antibody design. Protein Eng Des Sel (2012) 1.44
Physics-based scoring of protein-ligand complexes: enrichment of known inhibitors in large-scale virtual screening. J Chem Inf Model (2006) 1.43
Retracted Ferroportin in the progression and prognosis of hepatocellular carcinoma. Eur J Med Res (2013) 1.43
Complications of sling surgery among female Medicare beneficiaries. Obstet Gynecol (2007) 1.41
Prognostic value of vascular endothelial growth factor expression in patients with lung cancer: a systematic review with meta-analysis. J Thorac Oncol (2009) 1.41
Thromboembolic complications of sling surgery for stress urinary incontinence among female Medicare beneficiaries. Urology (2009) 1.41
Dominant antigenic peptides located at the heavy chain terminal of botulinum neurotoxin B contain receptor-binding sites for synaptotagmin II. Biochem Biophys Res Commun (2008) 1.40
Divergent evolution in enolase superfamily: strategies for assigning functions. J Biol Chem (2011) 1.40
Assignment of polar states for protein amino acid residues using an interaction cluster decomposition algorithm and its application to high resolution protein structure modeling. Proteins (2007) 1.39
Quantitative proteomic analysis of age-related changes in human cerebrospinal fluid. Neurobiol Aging (2005) 1.39
Quantitative proteomics of cerebrospinal fluid from patients with Alzheimer disease. J Alzheimers Dis (2005) 1.39
In utero diagnosis of Norrie disease and early laser preserves visual acuity. Arch Ophthalmol (2010) 1.39
Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1. Am J Hum Genet (2013) 1.39
Peripheral retinal nonperfusion in septo-optic dysplasia (de Morsier syndrome). Arch Ophthalmol (2011) 1.39
Common genetic determinants of breast-cancer risk in East Asian women: a collaborative study of 23 637 breast cancer cases and 25 579 controls. Hum Mol Genet (2013) 1.38
Laser photocoagulation at birth prevents blindness in Norrie's disease diagnosed using amniocentesis. Ophthalmology (2010) 1.38
Characterization of protein kinase CK2 from Trypanosoma brucei. Mol Biochem Parasitol (2006) 1.37
Novel human lipoxygenase inhibitors discovered using virtual screening with homology models. J Med Chem (2006) 1.36
Conformational changes in protein loops and helices induced by post-translational phosphorylation. PLoS Comput Biol (2006) 1.36
Direct treatment cost of atrial fibrillation in the elderly American population: a Medicare perspective. J Med Econ (2008) 1.35
The effect of age on outcomes of sling surgery for urinary incontinence. J Am Geriatr Soc (2007) 1.34
Molecular mechanics methods for predicting protein-ligand binding. Phys Chem Chem Phys (2006) 1.34
An exploratory instrumental variable analysis of the outcomes of localized breast cancer treatments in a medicare population. Health Econ (2003) 1.34
Turning a protein kinase on or off from a single allosteric site via disulfide trapping. Proc Natl Acad Sci U S A (2011) 1.33
Hyperinsulinemia provokes synchronous increases in central inflammation and beta-amyloid in normal adults. Arch Neurol (2005) 1.33
The NOG1 GTP-binding protein is required for biogenesis of the 60 S ribosomal subunit. J Biol Chem (2003) 1.33
Tetra-arsenic tetra-sulfide for the treatment of acute promyelocytic leukemia: a pilot report. Blood (2002) 1.32
Evolution of structure and function in the o-succinylbenzoate synthase/N-acylamino acid racemase family of the enolase superfamily. J Mol Biol (2006) 1.31
Ezrin/radixin/moesin proteins are phosphorylated by TNF-alpha and modulate permeability increases in human pulmonary microvascular endothelial cells. J Immunol (2006) 1.31
Strengths of hydrogen bonds involving phosphorylated amino acid side chains. J Am Chem Soc (2007) 1.31
Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole. PLoS Negl Trop Dis (2010) 1.30
A study of cycling induced degradation mechanisms in Si nanocrystal memory devices. Nanotechnology (2011) 1.30
Surfaces affect ion pairing. J Phys Chem B (2005) 1.29
CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer. J Clin Oncol (2012) 1.29
A group II intron-encoded maturase functions preferentially in cis and requires both the reverse transcriptase and X domains to promote RNA splicing. J Mol Biol (2004) 1.27
A common reference framework for analyzing/comparing proteins and ligands. Fingerprints for Ligands and Proteins (FLAP): theory and application. J Chem Inf Model (2007) 1.24
Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities. Proc Natl Acad Sci U S A (2007) 1.23
Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer. Cancer Epidemiol Biomarkers Prev (2011) 1.23