Carboplatin and pemetrexed with or without pembrolizumab for advanced, non-squamous non-small-cell lung cancer: a randomised, phase 2 cohort of the open-label KEYNOTE-021 study.

PubWeight™: 1.77‹?› | Rank: Top 3%

🔗 View Article (PMID 27745820)

Published in Lancet Oncol on October 10, 2016

Authors

Corey J Langer1, Shirish M Gadgeel2, Hossein Borghaei3, Vassiliki A Papadimitrakopoulou4, Amita Patnaik5, Steven F Powell6, Ryan D Gentzler7, Renato G Martins8, James P Stevenson9, Shadia I Jalal10, Amit Panwalkar11, James Chih-Hsin Yang12, Matthew Gubens13, Lecia V Sequist14, Mark M Awad15, Joseph Fiore16, Yang Ge16, Harry Raftopoulos16, Leena Gandhi17, KEYNOTE-021 investigators

Author Affiliations

1: Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA, USA. Electronic address: corey.langer@uphs.upenn.edu.
2: Karmanos Cancer Institute and Wayne State University, Detroit, MI, USA.
3: Fox Chase Cancer Center, Philadelphia, PA, USA.
4: The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
5: South Texas Accelerated Research Therapeutics, San Antonio, TX, USA.
6: Sanford Cancer Center, Sioux Falls, SD, USA.
7: University of Virginia, Charlottesville, VA, USA.
8: University of Washington and Seattle Cancer Care Alliance, Seattle, WA, USA.
9: Cleveland Clinic, Cleveland, OH, USA.
10: Indiana University School of Medicine, Indianapolis, IN, USA.
11: Sanford Roger Maris Cancer Center, Fargo, ND, USA.
12: National Taiwan University Hospital and National Taiwan University Cancer Center, Taipei, Taiwan.
13: University of California, San Francisco, San Francisco, CA, USA.
14: Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA.
15: Dana-Farber Cancer Institute, Boston, MA, USA.
16: Merck & Co Inc, Kenilworth, NJ, USA.
17: Dana-Farber Cancer Institute, Boston, MA, USA; Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York, NY, USA.

Associated clinical trials:

A Study of Pembrolizumab (MK-3475) in Combination With Chemotherapy or Immunotherapy in Participants With Lung Cancer (MK-3475-021/KEYNOTE-021) | NCT02039674

Concomitant Immune Check Point Inhibitor With Radiochemotherapy in Head And Neck Cancer | NCT03532737

IO102 With Pembrolizumab, With or Without Chemotherapy, as First-line Treatment of Metastatic NSCLC | NCT03562871

Platinum-Based Chemotherapy Plus Ramucirumab in Patients With Advanced NSCLC Who Have Progressed on First Line Anti-PD-1 Immunotherapy | NCT03904108

Immunotherapy, Chemotherapy, Radiotherapy and Surgery for Synchronous Oligo-metastatic NSCLC (CHESS) | NCT03965468

Efficacy and Safety of Toripalimab Combined With Docetaxel or Nab-paclitaxel in Patients With Advanced Gastric Cancer | NCT04563975

Articles citing this

Successes and failures: what did we learn from recent first-line treatment immunotherapy trials in non-small cell lung cancer? BMC Med (2017) 1.40

Systemic, perioperative management of muscle-invasive bladder cancer and future horizons. Nat Rev Clin Oncol (2016) 0.81

Update on Programmed Death-1 and Programmed Death-Ligand 1 Inhibition in the Treatment of Advanced or Metastatic Non-Small Cell Lung Cancer. Front Oncol (2017) 0.79

Targeting ALK: Precision Medicine Takes on Drug Resistance. Cancer Discov (2017) 0.78

Lung cancer: Anti-PD-1 therapy in the frontline. Nat Rev Clin Oncol (2016) 0.76

Comprehensive Meta-analysis of Key Immune-Related Adverse Events from CTLA-4 and PD-1/PD-L1 Inhibitors in Cancer Patients. Cancer Immunol Res (2017) 0.76

Efficacy of continuous EGFR-inhibition and role of Hedgehog in EGFR acquired resistance in human lung cancer cells with activating mutation of EGFR. Oncotarget (2017) 0.75

Biomarkers come of age: PD1 in the frontline and cell cycle therapy swells the ranks of personalised therapy in the European Society of Medical Oncology (ESMO) congress, Copenhagen, 7-10 October 2016. Ecancermedicalscience (2016) 0.75

Historical Evolution of Second-Line Therapy in Non-Small Cell Lung Cancer. Front Med (Lausanne) (2017) 0.75

Precision medicine in immune checkpoint blockade therapy for non-small cell lung cancer. Clin Transl Med (2017) 0.75

Preface on "Emerging treatment options for brain metastases from non-small cell lung cancer". Transl Lung Cancer Res (2016) 0.75

Emerging therapies for breast cancer. J Hematol Oncol (2017) 0.75

Checkpoint Inhibitors for Non-Small Cell Lung Cancer Among Older Adults. Curr Oncol Rep (2017) 0.75

PD-L1 expression indicates favorable prognosis for advanced lung adenocarcinoma patients treated with pemetrexed. Oncotarget (2017) 0.75

Genetic Characterization of Brain Metastases in the Era of Targeted Therapy. Front Oncol (2017) 0.75

Perspectives in immunotherapy: meeting report from the "Immunotherapy Bridge", Napoli, November 30th 2016. J Transl Med (2017) 0.75

Pembrolizumab-Induced Pancytopenia: A Case Report. Perm J (2017) 0.75

Standard of care in immunotherapy trials: Challenges and considerations. Hum Vaccin Immunother (2017) 0.75

Response to single agent PD-1 inhibitor after progression on previous PD-1/PD-L1 inhibitors: a case series. J Immunother Cancer (2017) 0.75

SELECT-3: a phase I study of selumetinib in combination with platinum-doublet chemotherapy for advanced NSCLC in the first-line setting. Br J Cancer (2017) 0.75

Immunotherapy and Targeted Therapy for Small Cell Lung Cancer: There Is Hope. Curr Oncol Rep (2017) 0.75

Tumor response dynamics of advanced non-small-cell lung cancer patients treated with PD-1 inhibitors: Imaging markers for treatment outcome. Clin Cancer Res (2017) 0.75

PD-1 and PD-L1 as emerging therapeutic targets in gastric cancer: current evidence. Gastrointest Cancer (2017) 0.75

Predictive biomarkers of immunotherapy for non-small cell lung cancer: results from an Experts Panel Meeting of the Italian Association of Thoracic Oncology. Transl Lung Cancer Res (2017) 0.75

Immune checkpoint inhibitors in lung cancer: the holy grail has not yet been found…. ESMO Open (2017) 0.75

ESMO Copenhagen 2016: a lung cancer 'grand cru'. ESMO Open (2017) 0.75

New PD-L1 inhibitors in non-small cell lung cancer - impact of atezolizumab. Lung Cancer (Auckl) (2017) 0.75