Published in Mol Cancer on November 03, 2016
The drebrin/EB3 pathway drives invasive activity in prostate cancer. Oncogene (2017) 0.75
Untangling the ErbB signalling network. Nat Rev Mol Cell Biol (2001) 28.05
Involvement of chemokine receptors in breast cancer metastasis. Nature (2001) 26.07
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell (2005) 18.20
A multigenic program mediating breast cancer metastasis to bone. Cancer Cell (2003) 16.86
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell (2011) 7.32
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature (2003) 5.57
Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res (2002) 5.00
Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. J Clin Invest (2011) 4.43
Cancer to bone: a fatal attraction. Nat Rev Cancer (2011) 4.08
NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J Biol Chem (2003) 3.98
A detergent-free method for purifying caveolae membrane from tissue culture cells. Proc Natl Acad Sci U S A (1995) 3.84
Regulation of the chemokine receptor CXCR4 by hypoxia. J Exp Med (2003) 3.71
Tumor immunobiological differences in prostate cancer between African-American and European-American men. Cancer Res (2008) 3.39
Role of high expression levels of CXCR4 in tumor growth, vascularization, and metastasis. FASEB J (2004) 2.94
Insolubility and redistribution of GPI-anchored proteins at the cell surface after detergent treatment. Mol Biol Cell (1995) 2.74
Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo. J Cell Biochem (2003) 2.62
A simplified method for the preparation of detergent-free lipid rafts. J Lipid Res (2005) 2.49
Skeletal localization and neutralization of the SDF-1(CXCL12)/CXCR4 axis blocks prostate cancer metastasis and growth in osseous sites in vivo. J Bone Miner Res (2004) 2.36
Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium. Cancer Res (2007) 2.02
CXCL12/CXCR4 signaling activates Akt-1 and MMP-9 expression in prostate cancer cells: the role of bone microenvironment-associated CXCL12. Prostate (2006) 1.86
Resistance to HER2-directed antibodies and tyrosine kinase inhibitors: mechanisms and clinical implications. Cancer Biol Ther (2011) 1.84
Chemokine receptor CXCR4 expression and prognosis in patients with metastatic prostate cancer. Cancer Sci (2008) 1.67
A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. J Biol Chem (2006) 1.47
Second cysteine-rich region of epidermal growth factor receptor contains targeting information for caveolae/rafts. J Biol Chem (2002) 1.39
The importance of the CXCL12-CXCR4 chemokine ligand-receptor interaction in prostate cancer metastasis. J Exp Ther Oncol (2004) 1.32
Low level HER2 overexpression is associated with rapid tumor cell proliferation and poor prognosis in prostate cancer. Clin Cancer Res (2010) 1.28
CXCR4 expression in prostate cancer progenitor cells. PLoS One (2012) 1.25
CXCL12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone. Mol Cancer Res (2008) 1.23
PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling. Mol Cancer (2013) 1.14
Interaction of ligand-receptor system between stromal-cell-derived factor-1 and CXC chemokine receptor 4 in human prostate cancer: a possible predictor of metastasis. Biochem Biophys Res Commun (2004) 1.14
Functional expression of the CXCR4 chemokine receptor is induced by RET/PTC oncogenes and is a common event in human papillary thyroid carcinomas. Oncogene (2004) 1.14
CXCR4 over-expression and survival in cancer: a system review and meta-analysis. Oncotarget (2015) 1.04
The clinicopathological significance of the expression of CXCR4 protein in oral squamous cell carcinoma. Int J Oncol (2004) 1.03
CXCR4 and CXCL12 (SDF-1) in prostate cancer: inhibitory effects of human single chain Fv antibodies. Clin Cancer Res (2004) 1.03
Carboxyl-terminal Src kinase homologous kinase negatively regulates the chemokine receptor CXCR4 through YY1 and impairs CXCR4/CXCL12 (SDF-1alpha)-mediated breast cancer cell migration. Cancer Res (2005) 0.99
Androgens Induce Functional CXCR4 through ERG Factor Expression in TMPRSS2-ERG Fusion-Positive Prostate Cancer Cells. Transl Oncol (2010) 0.99
Membrane lipid rafts, master regulators of hematopoietic stem cell retention in bone marrow and their trafficking. Leukemia (2015) 0.97
Transcriptional regulation of CXCR4 in prostate cancer: significance of TMPRSS2-ERG fusions. Mol Cancer Res (2013) 0.89
Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5. Mol Cancer (2013) 0.85
Rapid Remodeling of Invadosomes by Gi-coupled Receptors: DISSECTING THE ROLE OF Rho GTPases. J Biol Chem (2016) 0.82
Meta-Analysis of the Relationship between CXCR4 Expression and Metastasis in Prostate Cancer. World J Mens Health (2014) 0.80
CXCR4 pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical models. Prostate (2015) 0.78