Vaccination of stage III/IV melanoma patients with long NY-ESO-1 peptide and CpG-B elicits robust CD8(+) and CD4(+) T-cell responses with multiple specificities including a novel DR7-restricted epitope.

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Published in Oncoimmunology on September 09, 2016

Authors

P Baumgaertner1, C Costa Nunes1, A Cachot1, H Maby-El Hajjami2, L Cagnon3, M Braun1, L Derré4, J-P Rivals5, D Rimoldi1, S Gnjatic6, S Abed Maillard3, P Marcos Mondéjar2, M P Protti7, E Romano3, O Michielin2, P Romero2, D E Speiser2, C Jandus1

Author Affiliations

1: Ludwig Cancer Research Center, Department of Oncology, University of Lausanne , Switzerland.
2: Ludwig Cancer Research Center, Department of Oncology, University of Lausanne, Switzerland; Department of Oncology, University Hospital Center (CHUV), Lausanne, Switzerland.
3: Department of Oncology, University Hospital Center (CHUV) , Lausanne, Switzerland.
4: Urology Research Unit, Urology Department, University Hospital Center (CHUV) , Lausanne, Switzerland.
5: Department of Otorhinolaryngology - Head and Neck Surgery, CHUV, University of Lausanne , Switzerland.
6: Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai , New York, USA.
7: Tumor Immunology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Associated clinical trials:

Immunotherapy of Stage III/IV Melanoma Patients | NCT00112242

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