Published in Mol Endocrinol on June 01, 1989
CYP17 inhibitors for prostate cancer therapy. J Steroid Biochem Mol Biol (2010) 1.70
Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice. Endocr Rev (2009) 1.55
Extragonadal aromatization increases with time after ovariectomy in rats. Reprod Biol Endocrinol (2005) 0.97
Differential hydrogen bonding in human CYP17 dictates hydroxylation versus lyase chemistry. Angew Chem Int Ed Engl (2013) 0.91
The developmental increase in adrenocortical 17,20-lyase activity (biochemical adrenarche) is driven primarily by increasing cytochrome b5 in neonatal rhesus macaques. Endocrinology (2008) 0.90
Phosphorylation of human cytochrome P450c17 by p38α selectively increases 17,20 lyase activity and androgen biosynthesis. J Biol Chem (2013) 0.82
Mice lacking Mrp1 have reduced testicular steroid hormone levels and alterations in steroid biosynthetic enzymes. Gen Comp Endocrinol (2010) 0.79
Expression of P450c17 in the human fetal nervous system. Endocrinology (2012) 0.75
New nucleotide sequence data on the EMBL File Server. Nucleic Acids Res (1990) 0.75
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics (1996) 6.12
Crystal structure of cytochrome P450 14alpha -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors. Proc Natl Acad Sci U S A (2001) 2.90
Expression and enzymatic activity of recombinant cytochrome P450 17 alpha-hydroxylase in Escherichia coli. Proc Natl Acad Sci U S A (1991) 2.75
Regulation of the synthesis of steroidogenic enzymes in adrenal cortical cells by ACTH. Annu Rev Physiol (1988) 1.82
Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension. Proc Natl Acad Sci U S A (2001) 1.61
Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (1999) 1.60
Radioimmunoassay of myoglobin in human serum. Results in patients with acute myocardial infarction. J Clin Invest (1975) 1.55
Expression of bovine 17 alpha-hydroxylase cytochrome P-450 cDNA in nonsteroidogenic (COS 1) cells. Science (1986) 1.45
Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism. Arch Biochem Biophys (1988) 1.43
Sequences of the Escherichia coli photolyase gene and protein. J Biol Chem (1984) 1.37
Prospective evaluation of patients with suspected hip fracture and indeterminate radiographs: use of T1-weighted MR images. Radiology (1993) 1.36
The NCI-H295 cell line: a pluripotent model for human adrenocortical studies. Mol Cell Endocrinol (1994) 1.34
17 alpha-hydroxylase/17,20-lyase deficiency: from clinical investigation to molecular definition. Endocr Rev (1991) 1.33
Flavodoxin and NADPH-flavodoxin reductase from Escherichia coli support bovine cytochrome P450c17 hydroxylase activities. J Biol Chem (1994) 1.32
Putidaredoxin reductase and putidaredoxin. Cloning, sequence determination, and heterologous expression of the proteins. J Biol Chem (1990) 1.32
Serum myoglobin level as diagnostic test in patients with acute myocardial infarction. Br Heart J (1977) 1.32
Identification and characterization of cDNA clones specific for cholesterol side-chain cleavage cytochrome P-450. Proc Natl Acad Sci U S A (1984) 1.30
Substrate recognition sites in 14alpha-sterol demethylase from comparative analysis of amino acid sequences and X-ray structure of Mycobacterium tuberculosis CYP51. J Inorg Biochem (2001) 1.25
Human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase from placenta: expression in nonsteroidogenic cells of a protein that catalyzes the dehydrogenation/isomerization of C21 and C19 steroids. Endocrinology (1990) 1.24
Transcriptional regulation of steroid hydroxylase genes by corticotropin. Proc Natl Acad Sci U S A (1986) 1.23
The role of cytochrome b5 in the biosynthesis of androgens by human P450c17. Arch Biochem Biophys (1995) 1.23
Human NCI-H295 adrenocortical carcinoma cells: a model for angiotensin-II-responsive aldosterone secretion. Endocrinology (1993) 1.23
Bovine adrenocortical cytochrome P-450(17 alpha). Regulation of gene expression by ACTH and elucidation of primary sequence. J Biol Chem (1986) 1.21
Spectral characterization of human hemoglobin and its derivatives. Methods Enzymol (1978) 1.21
Molecular cloning and amino acid sequence of the precursor form of bovine adrenodoxin: evidence for a previously unidentified COOH-terminal peptide. Proc Natl Acad Sci U S A (1985) 1.19
Expression and purification of functional human 17 alpha-hydroxylase/17,20-lyase (P450c17) in Escherichia coli. Use of this system for study of a novel form of combined 17 alpha-hydroxylase/17,20-lyase deficiency. J Biol Chem (1993) 1.17
Sex-dependent expression of a transcription factor, Ad4BP, regulating steroidogenic P-450 genes in the gonads during prenatal and postnatal rat development. Development (1994) 1.17
Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells. Proc Natl Acad Sci U S A (1988) 1.16
Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways. J Biol Chem (1998) 1.16
The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols. Arch Biochem Biophys (1996) 1.16
High-level expression of functional human cytochrome P450 1A2 in Escherichia coli. FASEB J (1992) 1.15
Convenient construction of recA deletion derivatives of Escherichia coli. J Bacteriol (1983) 1.14
Biochemical differences between rat and human cytochrome P450c17 support the different steroidogenic needs of these two species. Biochemistry (1999) 1.13
Type 2 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid and activity in human placenta and fetal membranes: its relationship to birth weight and putative role in fetal adrenal steroidogenesis. J Clin Endocrinol Metab (1995) 1.13
Ketoconazole: a potent inhibitor of cytochrome P-450-dependent drug metabolism in rat liver. Drug Metab Dispos (1985) 1.12
Biodiversity of CYP51 in trypanosomes. Biochem Soc Trans (2006) 1.12
Imidazole antimycotics: inhibitors of steroid aromatase. Biochem Pharmacol (1985) 1.10
Inhibition of rat liver microsomal cytochrome P-450 steroid hydroxylase reactions by imidazole antimycotic agents. Biochem Pharmacol (1986) 1.08
Expression, purification, and enzymatic properties of recombinant human cytochrome P450c27 (CYP27). Arch Biochem Biophys (1997) 1.08
Direct expression of adrenodoxin reductase in Escherichia coli and the functional characterization. Biol Pharm Bull (1993) 1.07
Regulation by ACTH of steroid hormone biosynthesis in the adrenal cortex. Can J Biochem Cell Biol (1983) 1.07
Adrenarche results from development of a 3beta-hydroxysteroid dehydrogenase-deficient adrenal reticularis. J Clin Endocrinol Metab (1998) 1.07
Cytochrome P-450terp. Isolation and purification of the protein and cloning and sequencing of its operon. J Biol Chem (1992) 1.06
The hydrophobic amino-terminal sequence of bovine 17 alpha-hydroxylase is required for the expression of a functional hemoprotein in COS 1 cells. J Biol Chem (1991) 1.05
Effect of phenobarbital administration to rats on the level of the in vitro synthesis of cytochrome P-450 directed by total rat liver RNA. Biochem Biophys Res Commun (1979) 1.04
Methemoglobinemia from sniffing butyl nitrite. Ann Intern Med (1979) 1.04
Plasma and erythrocyte lipids in sickle cell anaemia. Clin Lab Haematol (1983) 1.03
NADPH-flavodoxin reductase and flavodoxin from Escherichia coli: characteristics as a soluble microsomal P450 reductase. Biochemistry (1998) 1.02
Identification by site-directed mutagenesis of two lysine residues in cholesterol side chain cleavage cytochrome P450 that are essential for adrenodoxin binding. J Biol Chem (1992) 1.01
Regulation of the biosynthesis of cytochromes P-450 involved in steroid hormone synthesis. Mol Cell Endocrinol (1985) 1.01
Synergistic activation of the human type II 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase promoter by the transcription factor steroidogenic factor-1/adrenal 4-binding protein and phorbol ester. J Biol Chem (1997) 1.00
Site-directed mutagenesis identifies amino acid residues associated with the dehydrogenase and isomerase activities of human type I (placental) 3beta-hydroxysteroid dehydrogenase/isomerase. J Steroid Biochem Mol Biol (1998) 1.00
3 beta-hydroxysteroid dehydrogenase/isomerase in the fetal zone and neocortex of the human fetal adrenal gland. Endocrinology (1990) 1.00
Drugs, alcohol and sex hormones: a molecular perspective of the receptivity of cytochrome P-450. Ann N Y Acad Sci (1973) 1.00
Expression of messenger ribonucleic acid species encoding steroidogenic enzymes in human follicles and corpora lutea throughout the menstrual cycle. J Clin Endocrinol Metab (1990) 0.98
Heterologous expression of mammalian P450 in COS cells. Methods Enzymol (1991) 0.97
An additional electrostatic interaction between adrenodoxin and P450c27 (CYP27A1) results in tighter binding than between adrenodoxin and p450scc (CYP11A1). J Biol Chem (1999) 0.97
Lifetime of adrenal cytochrome P-450 as influenced by ACTH. Ann N Y Acad Sci (1973) 0.97
Messenger RNAs encoding steroidogenic enzymes are expressed in rodent brain. Brain Res Mol Brain Res (1995) 0.97
Myoglobinemia is an early and quantitative index of acute myocardial infarction. Angiology (1978) 0.97
Immunolocalization of aromatase, 17 alpha-hydroxylase and side-chain-cleavage cytochromes P-450 in the human ovary. J Reprod Fertil (1989) 0.97
Induction of synthesis of mitochondrial steroidogenic enzymes of bovine adrenocortical cells by analogs of cyclic AMP. J Biol Chem (1984) 0.96
A cAMP-regulatory sequence (CRS1) of CYP17 is a cellular target for the homeodomain protein Pbx1. J Biol Chem (1994) 0.96
The human c-Ha-ras2 is a processed pseudogene inactivated by numerous base substitutions. Nucleic Acids Res (1984) 0.96
Activation of CYP11A and CYP11B gene promoters by the steroidogenic cell-specific transcription factor, Ad4BP. Mol Endocrinol (1993) 0.96
Studies on the synthesis of sterol carrier protein-2 in rat adrenocortical cells in monolayer culture. Regulation by ACTH and dibutyryl cyclic 3',5'-AMP. J Biol Chem (1987) 0.95
Regulation of human adrenal carcinoma cell (NCI-H295) production of C19 steroids. J Clin Endocrinol Metab (1993) 0.95
Folding requirements are different between sterol 14alpha-demethylase (CYP51) from Mycobacterium tuberculosis and human or fungal orthologs. J Biol Chem (2001) 0.95
Induction of synthesis of cholesterol side chain cleavage cytochrome P-450 by adrenocorticotropin in cultured bovine adrenocortical cells. J Biol Chem (1981) 0.95
Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo. Endocrinology (1995) 0.95
No mutation in cytochrome P450 side chain cleavage in a patient with congenital lipoid adrenal hyperplasia. J Clin Endocrinol Metab (1994) 0.95
Acceleration of the rate of deoxyhemoglobin S polymerization by the erythrocyte membrane. FEBS Lett (1980) 0.95
Immunohistochemical studies of steroidogenic enzymes (aromatase, 17 alpha-hydroxylase and cholesterol side-chain cleavage cytochromes P-450) in sex cord-stromal tumors of the ovary. Hum Pathol (1989) 0.94
Effects of adrenocorticotropin on 17 alpha-hydroxylase activity and cytochrome P-450(17 alpha) synthesis in bovine adrenocortical cells. J Biol Chem (1985) 0.94
The 5'-flanking regions of CYP19A1 and CYP19A2 in zebrafish. Biochem Biophys Res Commun (2001) 0.94
Transcriptional regulation of the bovine CYP17 (P-450(17)alpha) gene. Identification of two cAMP regulatory regions lacking the consensus cAMP-responsive element (CRE). J Biol Chem (1990) 0.94
Measurement of steroid hydroxylation reactions by high-performance liquid chromatography as indicator of P450 identity and function. Methods Enzymol (1991) 0.94
Differential control of 17 alpha-hydroxylase and 3 beta-hydroxysteroid dehydrogenase expression in human adrenocortical H295R cells. J Clin Endocrinol Metab (1996) 0.94
Regulation of steroid hydroxylase gene expression is multifactorial in nature. Recent Prog Horm Res (1989) 0.93
Angiotensin II inhibits luteinizing hormone-stimulated cholesterol side chain cleavage expression and stimulates basic fibroblast growth factor expression in bovine luteal cells in primary culture. J Biol Chem (1990) 0.93
Simultaneous transfection of COS-1 cells with mitochondrial and microsomal steroid hydroxylases: incorporation of a steroidogenic pathway into nonsteroidogenic cells. Proc Natl Acad Sci U S A (1988) 0.93
Members of the meis1 and pbx homeodomain protein families cooperatively bind a cAMP-responsive sequence (CRS1) from bovine CYP17. J Biol Chem (1998) 0.93
Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase. J Clin Endocrinol Metab (1993) 0.93
Ca(2+)-regulated expression of steroid hydroxylases in H295R human adrenocortical cells. Endocrinology (1995) 0.93
Type 2 11 beta-hydroxysteroid dehydrogenase in human fetal tissues. J Clin Endocrinol Metab (1994) 0.92
Cloning and functional expression of a thyrotropin receptor from the gonads of a vertebrate (bony fish): potential thyroid-independent role for thyrotropin in reproduction. Mol Cell Endocrinol (2000) 0.92
Protein synthesis inhibitors and ethanol selectively enhance heterologous expression of P450s and related proteins in Escherichia coli. Arch Biochem Biophys (1999) 0.92
Cyclic adenosine 3',5'-monophosphate(cAMP)/cAMP-responsive element modulator (CREM)-dependent regulation of cholesterogenic lanosterol 14alpha-demethylase (CYP51) in spermatids. Mol Endocrinol (1999) 0.92
Further studies on corticosteroidogenesis. 3. Effect of biological substrates and electron transport dependence in rat adrenal mitochondria. Biochim Biophys Acta (1966) 0.92
P450(17 alpha) and P450SCC gene expression and regulation in the rat placenta. Endocrinology (1992) 0.92