Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of renal cell carcinoma.

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Published in J Immunother Cancer on November 15, 2016

Authors

Brian I Rini1, David F McDermott2, Hans Hammers3, William Bro4, Ronald M Bukowski5, Bernard Faba6, Jo Faba6, Robert A Figlin7, Thomas Hutson8, Eric Jonasch9, Richard W Joseph10, Bradley C Leibovich11, Thomas Olencki12, Allan J Pantuck13, David I Quinn14, Virginia Seery2, Martin H Voss15, Christopher G Wood9, Laura S Wood1, Michael B Atkins16

Author Affiliations

1: Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Ave, Cleveland, OH 44195 USA.
2: Beth Israel Deaconess Medical Center, Dana-Farber/Harvard Cancer Center, 10 Highfield Circle, Milton, MA 02186 USA.
3: Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans St, Baltimore, MD 21287 USA.
4: Kidney Cancer Association, PO Box 4668 #38269, Chicago, IL 60680 USA.
5: Cleveland Clinic Taussig Cancer Institute, 1 Clinic Center, Cleveland, OH 44195 USA.
6: Patient and Patient Advocate, Cleveland, USA.
7: Cedars-Sinai Medical Center, 8700 Beverly Blvd., Saperstein Critical Care Tower, 1S28, Los Angeles, CA 90048 USA.
8: Charles A. Sammons Cancer Center, Baylor University Medical Center, 3410 Worth Street, Suite 400, Dallas, TX 75254, USA.
9: M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
10: Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA.
11: Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
12: The Ohio State University Medical Center, 320 W. 10th Avenue, Columbus, OH 43210, USA.
13: UCLA Institute of Urologic Oncology, 66-124 Center for Health Sciences, Los Angeles, CA 90095, USA.
14: Kenneth J. Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Ave Suite 3451, Los Angeles, CA 90033, USA.
15: Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
16: Georgetown-Lombardi Comprehensive Cancer Center, 3970 Reservoir Road, NW, Research Building, Room E501, Washington, DC 20057, USA.

Associated clinical trials:

BMS-936558 (MDX-1106) In Subjects With Advanced/Metastatic Clear-Cell Renal Cell Carcinoma (RCC) | NCT01354431

Study of Nivolumab (BMS-936558) vs. Everolimus in Pre-Treated Advanced or Metastatic Clear-cell Renal Cell Carcinoma (CheckMate 025) | NCT01668784

Nivolumab (BMS-936558; MDX-1106) in Combination With Sunitinib, Pazopanib, or Ipilimumab in Subjects With Metastatic Renal Cell Carcinoma (RCC) (CheckMate 016) | NCT01472081

Nivolumab Combined With Ipilimumab Versus Sunitinib in Previously Untreated Advanced or Metastatic Renal Cell Carcinoma (CheckMate 214) | NCT02231749

Nivolumab vs Nivolumab + Bevacizumab vs Nivolumab + Ipilimumab in Metastatic Renal Cell Carcinoma (mRCC) | NCT02210117

Safety and Efficacy Study of Pazopanib and MK 3475 in Advanced Renal Cell Carcinoma (RCC; KEYNOTE-018) | NCT02014636

S0931, Everolimus in Treating Patients With Kidney Cancer Who Have Undergone Surgery (S0931) | NCT01120249

Study of Hydroxychloroquine and Aldesleukin in Renal Cell Carcinoma Patients (RCC) | NCT01550367

Entinostat in Combination With Aldesleukin in Treating Patients With Metastatic Kidney Cancer | NCT01038778

A Study of Atezolizumab in Combination With Bevacizumab Versus Sunitinib in Participants With Untreated Advanced Renal Cell Carcinoma | NCT02420821

High Dose IL-2 and Stereotactic Ablative Body Radiation Therapy for Metastatic Renal Cancer | NCT01896271

Radiation Therapy and MK-3475 for Patients With Recurrent/Metastatic Head and Neck Cancer, Renal Cell Cancer, Melanoma, and Lung Cancer | NCT02318771

A Study Evaluating the Effect of Pembrolizumab (MK-3475) in Participants With Renal Cell Cancer (MK-3475-031) | NCT02212730

Study of High Dose Interleukin-2 (IL-2) and Stereotactic Body Radiation (SBRT) in Patients With Metastatic Renal Cancer | NCT02306954

Phase 1b/2 Trial of Lenvatinib (E7080) Plus Pembrolizumab in Subjects With Selected Solid Tumors | NCT02501096

Study of Neoadjuvant Nivolumab in Patients With Non-metastatic Stage II-IV Clear Cell Renal Cell Carcinoma | NCT02575222

A Study of Avelumab With Axitinib Versus Sunitinib In Advanced Renal Cell Cancer (JAVELIN Renal 101) | NCT02684006

PROCLAIM Registry to Evaluate the Treatment Patterns and Clinical Response in Malignancy | NCT01415167

Neoadjuvant MEDI 4736 +/- Tremelimumab in Locally Advanced Renal Cell Carcinoma | NCT02762006

NCT 01415167

A Study of Anti-PD1 (Nivolumab) Therapy as Pre- and Post-operative Therapy in Metastatic Renal Cell Cancer (ADAPTeR) (ADAPTeR) | NCT02446860

Study to Evaluate the Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Axitinib Versus Sunitinib Monotherapy in Participants With Renal Cell Carcinoma (MK-3475-426/KEYNOTE-426) | NCT02853331

Nivolumab in Treating Patients With HIgh-Risk Non-Metastatic Kidney Cancer | NCT02595918

NCT01575948

Lenvatinib/Everolimus or Lenvatinib/Pembrolizumab Versus Sunitinib Alone as Treatment of Advanced Renal Cell Carcinoma | NCT02811861

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