Published in Oncotarget on November 24, 2016
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature (2006) 24.52
Identification and expansion of human colon-cancer-initiating cells. Nature (2006) 24.44
International network of cancer genome projects. Nature (2010) 20.35
Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A (2007) 13.58
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov (2009) 10.32
Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature (2009) 10.31
Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell (2007) 7.05
Selective killing of cancer cells by a small molecule targeting the stress response to ROS. Nature (2011) 7.03
A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell (2010) 6.47
Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature (2008) 5.59
Annual report on status of cancer in China, 2011. Chin J Cancer Res (2015) 4.62
CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell (2011) 3.41
Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell (2013) 3.32
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc Natl Acad Sci U S A (2007) 3.20
Peroxiredoxin, a novel family of peroxidases. IUBMB Life (2001) 2.91
Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell (2015) 2.74
Colon cancer stem cells: promise of targeted therapy. Gastroenterology (2010) 2.58
Typical 2-Cys peroxiredoxins--structures, mechanisms and functions. FEBS J (2009) 2.57
Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells. Gastroenterology (2010) 2.55
Metabolic regulation in pluripotent stem cells during reprogramming and self-renewal. Cell Stem Cell (2012) 1.89
Stress defense in murine embryonic stem cells is superior to that of various differentiated murine cells. Stem Cells (2004) 1.67
Biological and genetic characteristics of tumor-initiating cells in colon cancer. Ann Surg Oncol (2007) 1.62
Redox regulation in stem-like cancer cells by CD44 variant isoforms. Oncogene (2013) 1.48
Reactive oxygen species in cancer stem cells. Antioxid Redox Signal (2012) 1.44
Redox homeostasis: the linchpin in stem cell self-renewal and differentiation. Cell Death Dis (2013) 1.31
Regulation of reactive oxygen species in stem cells and cancer stem cells. J Cell Physiol (2012) 1.30
Peroxiredoxin 1 controls prostate cancer growth through Toll-like receptor 4-dependent regulation of tumor vasculature. Cancer Res (2011) 1.23
NANOG modulates stemness in human colorectal cancer. Oncogene (2012) 1.19
Mitochondrial and energy metabolism-related properties as novel indicators of lung cancer stem cells. Int J Cancer (2011) 1.18
Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells. Nat Chem Biol (2012) 1.15
Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling. Trends Biochem Sci (2015) 1.14
ROS links glucose metabolism to breast cancer stem cell and EMT phenotype. Cancer Cell (2013) 1.10
Hedgehog signaling and the Gli code in stem cells, cancer, and metastases. Sci Signal (2011) 1.09
Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon. Ann Surg Oncol (2011) 1.09
Inhibition of mitochondria- and endoplasmic reticulum stress-mediated autophagy augments temozolomide-induced apoptosis in glioma cells. PLoS One (2012) 1.04
Roles of reactive oxygen species in the fate of stem cells. Antioxid Redox Signal (2012) 1.02
Hedgehog signalling in colon cancer and stem cells. EMBO Mol Med (2009) 1.01
Modulation of neuronal stem cell differentiation by hypoxia and reactive oxygen species. Prog Neurobiol (2011) 1.01
2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM). Proteomics (2006) 1.00
Colon cancer stem cells--from basic to clinical application. Cancer Lett (2012) 0.97
Peroxiredoxins in colorectal neoplasms. Histol Histopathol (2010) 0.95
A phase I study of imexon plus gemcitabine as first-line therapy for advanced pancreatic cancer. Cancer Chemother Pharmacol (2009) 0.94
The axis of mTOR-mitochondria-ROS and stemness of the hematopoietic stem cells. Cell Cycle (2009) 0.94
Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3. Biochem J (2010) 0.93
FOXM1-Induced PRX3 Regulates Stemness and Survival of Colon Cancer Cells via Maintenance of Mitochondrial Function. Gastroenterology (2015) 0.92
Piperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells. Neuro Oncol (2014) 0.86
Cancer stem cells, metabolism, and therapeutic significance. Tumour Biol (2016) 0.86
Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy. Oxid Med Cell Longev (2016) 0.85
Peroxiredoxin 2 knockdown by RNA interference inhibits the growth of colorectal cancer cells by downregulating Wnt/β-catenin signaling. Cancer Lett (2013) 0.83
Detoxification of oxidative stress in glioma stem cells: mechanism, clinical relevance, and therapeutic development. J Neurosci Res (2014) 0.82
Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nat Med (2016) 0.82
Phase 2 study of imexon, a prooxidant molecule, in relapsed and refractory B-cell non-Hodgkin lymphoma. Blood (2014) 0.82
Peroxiredoxin I is differentially expressed in multiple myelomas and in plasmablastic lymphomas. Oral Dis (2008) 0.81
Dominant role of peroxiredoxin/JNK axis in stemness regulation during neurogenesis from embryonic stem cells. Stem Cells (2014) 0.80
Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma. Oncotarget (2016) 0.78
Peroxiredoxin II Is Essential for Maintaining Stemness by Redox Regulation in Liver Cancer Cells. Stem Cells (2016) 0.77
Effective Killing of Cancer Cells Through ROS-Mediated Mechanisms by AMRI-59 Targeting Peroxiredoxin I. Antioxid Redox Signal (2015) 0.77
PX-12 inhibits the growth of hepatocelluar carcinoma by inducing S-phase arrest, ROS-dependent apoptosis and enhances 5-FU cytotoxicity. Am J Transl Res (2015) 0.76
Loss of Peroxiredoxin Expression Is Associated with an Aggressive Phenotype in Pancreatic Adenocarcinoma. Anticancer Res (2016) 0.76
Peroxiredoxin 2 knockdown by RNA interference inhibits the growth of colorectal cancer cells by downregulating Wnt/β-catenin signaling. Cancer Lett (2013) 0.83
Fbxw7 regulates tumor apoptosis, growth arrest and the epithelial-to-mesenchymal transition in part through the RhoA signaling pathway in gastric cancer. Cancer Lett (2015) 0.81