Published in N Engl J Med on November 13, 2016
Prospective Electronic Polygenic Risk Study (PEPRS1) | NCT05072275
Prospective Electronic Polygenic Risk Study - Second Phase (PEPRS2) | NCT05175651
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. PLoS Med (2017) 1.42
Genetics of CHD in 2016: Common and rare genetic variants and risk of CHD. Nat Rev Cardiol (2017) 1.07
Genetic Risk, Lifestyle, and Coronary Artery Disease. N Engl J Med (2017) 0.97
Genetic Risk, Lifestyle, and Coronary Artery Disease. N Engl J Med (2017) 0.96
Genetic Risk, Lifestyle, and Coronary Artery Disease. N Engl J Med (2017) 0.95
Mendelian Randomization: Using Natural Genetic Variation to Assess the Causal Role of Modifiable Risk Factors in Observational Studies. Circulation (2017) 0.82
Polygenic Risk Score Identifies Subgroup with Higher Burden of Atherosclerosis and Greater Relative Benefit from Statin Therapy in the Primary Prevention Setting. Circulation (2017) 0.82
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet (2017) 0.80
Genetics of coronary artery disease: discovery, biology and clinical translation. Nat Rev Genet (2017) 0.76
Protective influence of healthful nutrition on mechanisms of environmental pollutant toxicity and disease risks. Ann N Y Acad Sci (2017) 0.75
Diet and exercise changes following direct-to-consumer personal genomic testing. BMC Med Genomics (2017) 0.75
Psychological stress and risk of incident atrial fibrillation in men and women with known atrial fibrillation genetic risk scores. Sci Rep (2017) 0.75
Conceptual Foundations of Systems Biology Explaining Complex Cardiac Diseases. Healthcare (Basel) (2017) 0.75
The interplay between genetics, epigenetics and environment in modulating the risk of coronary heart disease. Ann Transl Med (2016) 0.75
Cardiovascular disease prevention: lifestyle attenuation of genetic risk. Nat Rev Cardiol (2017) 0.75
Genetic Risk and Altering Lipids With Lifestyle Changes and Metformin: Is Fate Modifiable? Circ Cardiovasc Genet (2016) 0.75
Health, Health Care, and Systems Science: Emerging Paradigm. Cureus (2017) 0.75
Systems Chronotherapeutics. Pharmacol Rev (2017) 0.75
Association between pet ownership and coronary artery disease in a Chinese population. Medicine (Baltimore) (2017) 0.75
Effect of Exceptional Parental Longevity and Lifestyle Factors on Prevalence of Cardiovascular Disease in Offspring. Am J Cardiol (2017) 0.75
Effect of Disclosing Genetic Risk for Coronary Heart Disease on Information Seeking and Sharing: The MI-GENES Study (Myocardial Infarction Genes). Circ Cardiovasc Genet (2017) 0.75
The Promise and Practice of Genetics on Diabetes Care: The Fog Rises to Reveal a Field of Genetic Complexity in HNF1B. Diabetes Care (2017) 0.75
Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk. Am J Hum Genet (2017) 0.75
Lifestyle Medicine and the Management of Cardiovascular Disease. Curr Cardiol Rep (2017) 0.75
Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet (2006) 115.71
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 56.72
The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. The ARIC investigators. Am J Epidemiol (1989) 37.83
Genomewide association analysis of coronary artery disease. N Engl J Med (2007) 24.38
A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37
A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science (2007) 18.96
Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's strategic Impact Goal through 2020 and beyond. Circulation (2010) 13.28
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19
Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med (2008) 9.83
Primary prevention of coronary heart disease in women through diet and lifestyle. N Engl J Med (2000) 9.05
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med (1994) 7.47
A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. Lancet (2010) 6.07
The Malmo Diet and Cancer Study. Design and feasibility. J Intern Med (1993) 5.35
Community prevalence of ideal cardiovascular health, by the American Heart Association definition, and relationship with cardiovascular disease incidence. J Am Coll Cardiol (2011) 5.30
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. Nat Genet (2011) 5.23
Trends in cardiovascular health metrics and associations with all-cause and CVD mortality among US adults. JAMA (2012) 5.17
New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet (2009) 5.12
Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring. JAMA (2004) 4.63
Association between a literature-based genetic risk score and cardiovascular events in women. JAMA (2010) 4.46
Rationale, design, and methodology of the Women's Genome Health Study: a genome-wide association study of more than 25,000 initially healthy american women. Clin Chem (2007) 4.45
Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials. Lancet (2015) 3.75
Young candidates for coronary heart disease. J Am Med Assoc (1951) 3.50
The increased risk of death from ischaemic heart disease in first degree relatives of 121 men and 96 women with ischaemic heart disease. J Med Genet (1966) 2.89
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet (2015) 2.84
Prevalence, impact, and predictive value of detecting subclinical coronary and carotid atherosclerosis in asymptomatic adults: the BioImage study. J Am Coll Cardiol (2015) 2.51
Large-scale gene-centric analysis identifies novel variants for coronary artery disease. PLoS Genet (2011) 2.27
Ideal cardiovascular health: associations with biomarkers and subclinical disease and impact on incidence of cardiovascular disease in the Framingham Offspring Study. Circulation (2014) 2.04
Low-risk diet and lifestyle habits in the primary prevention of myocardial infarction in men: a population-based prospective cohort study. J Am Coll Cardiol (2014) 1.91
A genetic risk score is associated with incident cardiovascular disease and coronary artery calcium: the Framingham Heart Study. Circ Cardiovasc Genet (2012) 1.81
Healthy lifestyle in the primordial prevention of cardiovascular disease among young women. J Am Coll Cardiol (2015) 1.79
Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history. Eur Heart J (2015) 1.65
Multilocus genetic risk scores for coronary heart disease prediction. Arterioscler Thromb Vasc Biol (2013) 1.32
A genetic risk score based on direct associations with coronary heart disease improves coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC), but not in the Rotterdam and Framingham Offspring, Studies. Atherosclerosis (2012) 1.21
Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. Circulation (2016) 1.13
Genes, the heart and destiny. N Engl J Med (1957) 0.91