Spatiotemporal antagonism in mesenchymal-epithelial signaling in sweat versus hair fate decision.

PubWeight™: 0.85‹?›

🔗 View Article (PMID 28008008)

Published in Science on December 23, 2016

Authors

Catherine P Lu1, Lisa Polak1, Brice E Keyes1, Elaine Fuchs2,3

Author Affiliations

1: Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA.
2: Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA. fuchslb@rockefeller.edu.
3: Howard Hughes Medical Institute, Chevy Chase, MD, 20815-6789, USA.

Articles citing this

The "tao" of integuments. Science (2017) 0.75

miRNAs are required for post-induction stage sweat gland development. J Invest Dermatol (2017) 0.75

Articles cited by this

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol (2010) 75.21

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks. Nat Protoc (2012) 35.75

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev Biol (2001) 31.56

Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development (1999) 9.82

Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol (2002) 8.60

The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci U S A (1999) 7.67

WNT signals are required for the initiation of hair follicle development. Dev Cell (2002) 6.63

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev (1994) 6.07

Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development (2001) 4.89

Links between signal transduction, transcription and adhesion in epithelial bud development. Nature (2003) 4.88

X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Nat Genet (1996) 3.90

Tcf3 governs stem cell features and represses cell fate determination in skin. Cell (2006) 3.88

Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature (1994) 3.72

Requirement for BMP signaling in interdigital apoptosis and scale formation. Science (1996) 3.40

A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res (2006) 3.06

Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol (1999) 2.99

Instructive role of Wnt/beta-catenin in sensory fate specification in neural crest stem cells. Science (2004) 2.82

Lhx2 maintains stem cell character in hair follicles. Science (2006) 2.78

Generation of Bmpr/Alk3 conditional knockout mice. Genesis (2002) 2.71

Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development. Genes Dev (1996) 2.42

BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties. Genes Dev (2008) 2.41

Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell (2013) 2.17

Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17

Epithelial-mesenchymal signaling during the regionalization of the chick gut. Development (1998) 2.05

Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos. Nat Med (2010) 2.01

The mouse Engrailed-1 gene and ventral limb patterning. Nature (1996) 1.98

Stimulation of ectodermal organ development by Ectodysplasin-A1. Dev Biol (2003) 1.88

A dermal HOX transcriptional program regulates site-specific epidermal fate. Genes Dev (2008) 1.85

Organ specificity in mesenchymal induction demonstrated in the embryonic development of the mammary gland of the mouse. Dev Biol (1969) 1.72

Morpho-regulation of ectodermal organs: integument pathology and phenotypic variations in K14-Noggin engineered mice through modulation of bone morphogenic protein pathway. Am J Pathol (2004) 1.72

Opposing transcriptional outputs of Hedgehog signaling and engrailed control compartmental cell sorting at the Drosophila A/P boundary. Cell (2000) 1.60

Evo-devo of feathers and scales: building complex epithelial appendages. Curr Opin Genet Dev (2000) 1.56

BMPs mediate lateral inhibition at successive stages in feather tract development. Development (1998) 1.56

Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression. Development (2007) 1.53

WNT-SHH Antagonism Specifies and Expands Stem Cells prior to Niche Formation. Cell (2016) 1.52

Transit-amplifying cells orchestrate stem cell activity and tissue regeneration. Cell (2014) 1.50

Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases. Hum Mutat (2011) 1.42

FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate. Development (2009) 1.35

BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear mice. Dev Biol (1994) 1.34

Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop. Genes Dev (2012) 1.33

Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation. Nat Cell Biol (2012) 1.22

Adult corneal epithelium basal cells possess the capacity to activate epidermal, pilosebaceous and sweat gland genetic programs in response to embryonic dermal stimuli. Development (2000) 1.20

Directional cell migration, but not proliferation, drives hair placode morphogenesis. Dev Cell (2014) 1.15

Requirements for transcriptional repression and activation by Engrailed in Drosophila embryos. Development (2003) 1.07

BMPs are necessary for stomach gland formation in the chicken embryo: a study using virally induced BMP-2 and Noggin expression. Development (2000) 1.03

The specification of feather and scale protein synthesis in epidermal-dermal recombinations. Dev Biol (1978) 0.97

Pattern formation in skin development. Int J Dev Biol (1990) 0.96

Conversion of the nipple to hair-bearing epithelia by lowering bone morphogenetic protein pathway activity at the dermal-epidermal interface. Am J Pathol (2008) 0.94

Mutations in WNT10A are frequently involved in oligodontia associated with minor signs of ectodermal dysplasia. Am J Med Genet A (2013) 0.93

Involvement of Wnt, Eda and Shh at defined stages of sweat gland development. Development (2014) 0.91

Drosophila wingless sustains engrailed expression only in adjoining cells: evidence from mosaic embryos. Cell (1994) 0.89

How and when the regional competence of chick epidermis is established: feathers vs. scutate and reticulate scales, a problem en route to a solution. Int J Dev Biol (2004) 0.85

A genetic basis of variation in eccrine sweat gland and hair follicle density. Proc Natl Acad Sci U S A (2015) 0.82