The mucosal immune system: master regulator of bidirectional gut-brain communications.

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Published in Nat Rev Gastroenterol Hepatol on January 18, 2017

Authors

Nick Powell1, Marjorie M Walker2, Nicholas J Talley2

Author Affiliations

1: Experimental Immunobiology, Division of Transplant Immunology and Mucosal Biology, Great Maze Pond, King's College London, SE1 9RT, UK.
2: University of Newcastle, Faculty of Health and Medicine, School of Medicine &Public Health, Callaghan NSW 2308, Australia.

Associated clinical trials:

Role of the Gut Microbiome in Complex Regional Pain Syndrome | NCT03612193

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Noradrenergic and peptidergic innervation of lymphoid tissue. J Immunol (1985) 2.05

Self-reported abuse and gastrointestinal disease in outpatients: association with irritable bowel-type symptoms. Am J Gastroenterol (1995) 1.99

Symptomatic overlap between irritable bowel syndrome and microscopic colitis. Inflamm Bowel Dis (2007) 1.97

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Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12. J Clin Invest (1997) 1.94

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Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome. Neurogastroenterol Motil (2012) 1.87

Terminal ileal mucosal mast cells in irritable bowel syndrome. Dig Dis Sci (1993) 1.83

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IL-6 increases endothelial permeability in vitro. Endocrinology (1992) 1.73

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Norepinephrine, the beta-adrenergic receptor, and immunity. Brain Behav Immun (2002) 1.52

Inflammatory bowel disease: a study of the association between anxiety and depression, physical morbidity, and nutritional status. Scand J Gastroenterol (1997) 1.52

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Bone-marrow-derived microglia: myth or reality? Curr Opin Pharmacol (2008) 1.48

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