Published in Biomed Tech (Berl) on January 23, 2017
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Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science (2005) 6.88
PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science (2006) 6.25
Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion. Proc Natl Acad Sci U S A (2007) 5.31
Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels. Science (2006) 5.10
Long-term survival with glioblastoma multiforme. Brain (2007) 4.51
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Feedback loops shape cellular signals in space and time. Science (2008) 3.42
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A local coupling model and compass parameter for eukaryotic chemotaxis. Dev Cell (2005) 3.02
A localized Wnt signal orients asymmetric stem cell division in vitro. Science (2013) 2.82
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A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proc Natl Acad Sci U S A (2008) 2.34
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Probing the precision of the mitotic clock with a live-cell fluorescent biosensor. Nat Biotechnol (2004) 1.74
Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging. Mol Cell (2008) 1.73
Predictive impact of MGMT promoter methylation in glioblastoma of the elderly. Int J Cancer (2012) 1.67
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Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin B1. Curr Biol (2007) 1.63
Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas. Int J Cancer (2011) 1.61
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A network of Rab GTPases controls phagosome maturation and is modulated by Salmonella enterica serovar Typhimurium. J Cell Biol (2007) 1.52
Robust neuronal symmetry breaking by Ras-triggered local positive feedback. Curr Biol (2007) 1.49
Optimal experimental design for parameter estimation of a cell signaling model. PLoS Comput Biol (2009) 1.47
Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus. J Neurosci (2006) 1.45
Evaluation of the atrophogenic potential of hydrocortisone 1% cream and pimecrolimus 1% cream in uninvolved forehead skin of patients with atopic dermatitis using optical coherence tomography. Exp Dermatol (2011) 1.43
The role of saline flush injection rate in displacement of CT-injectable peripherally inserted central catheter tip during power injection of contrast material. AJR Am J Roentgenol (2014) 1.42
siRNA screen of the human signaling proteome identifies the PtdIns(3,4,5)P3-mTOR signaling pathway as a primary regulator of transferrin uptake. Genome Biol (2007) 1.41
Changes in exhaled nitric oxide and breath pH during fluticasone wean in asthma. Respiration (2009) 1.38
Highly specific overexpression of the transcription factor SOX11 in human malignant gliomas. Oncol Rep (2005) 1.37
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Quantitative analysis of cell cycle phase durations and PC12 differentiation using fluorescent biosensors. Cell Cycle (2009) 1.31
A PI3-kinase signaling code for insulin-triggered insertion of glucose transporters into the plasma membrane. Curr Biol (2002) 1.31
Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane. Mol Biol Cell (2008) 1.30
Spatial positive feedback at the onset of mitosis. Cell (2012) 1.26
Parallel single-cell monitoring of receptor-triggered membrane translocation of a calcium-sensing protein module. Science (2002) 1.26
Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme. J Neurooncol (2006) 1.26
Role for reelin in the development of granule cell dispersion in temporal lobe epilepsy. J Neurosci (2002) 1.26
An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. J Cell Biol (2007) 1.25
CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme. Carcinogenesis (2007) 1.25
Cooperative activation of PI3K by Ras and Rho family small GTPases. Mol Cell (2012) 1.23
The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease. Stem Cells (2007) 1.21
Specific localization and timing in neuronal signal transduction mediated by protein-lipid interactions. Neuron (2003) 1.21
The phosphoinositide phosphatase SopB manipulates membrane surface charge and trafficking of the Salmonella-containing vacuole. Cell Host Microbe (2010) 1.20
Antibacterial autophagy occurs at PI(3)P-enriched domains of the endoplasmic reticulum and requires Rab1 GTPase. Autophagy (2011) 1.20
Ca2+ pulses control local cycles of lamellipodia retraction and adhesion along the front of migrating cells. Curr Biol (2012) 1.18
Different molecular patterns in glioblastoma multiforme subtypes upon recurrence. J Neurooncol (2009) 1.17
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A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size. Genes Dev (2008) 1.14
A steering model of endothelial sheet migration recapitulates monolayer integrity and directed collective migration. Mol Cell Biol (2010) 1.13
Evolutionary origins of STIM1 and STIM2 within ancient Ca2+ signaling systems. Trends Cell Biol (2011) 1.12
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Suspended-drop electroporation for high-throughput delivery of biomolecules into cells. Nat Methods (2008) 1.10
A comparative Raman and CARS imaging study of colon tissue. J Biophotonics (2009) 1.10
Dissecting the role of PtdIns(4,5)P2 in endocytosis and recycling of the transferrin receptor. J Cell Sci (2008) 1.10
Neurogenesis in the dentate gyrus depends on ciliary neurotrophic factor and signal transducer and activator of transcription 3 signaling. Stem Cells (2009) 1.08
Active EGF receptors have limited access to PtdIns(4,5)P(2) in endosomes: implications for phospholipase C and PI 3-kinase signaling. J Cell Sci (2002) 1.08
Hypermethylation of the proapoptotic gene TMS1/ASC: prognostic importance in glioblastoma multiforme. J Neurooncol (2006) 1.08
An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis. J Cell Biol (2009) 1.08
Spines and neurite branches function as geometric attractors that enhance protein kinase C action. J Cell Biol (2005) 1.07
A critical intramolecular interaction for protein kinase Cepsilon translocation. J Biol Chem (2004) 1.06
Regulators of calcium homeostasis identified by inference of kinetic model parameters from live single cells perturbed by siRNA. Sci Signal (2013) 1.06
Regulated RalBP1 binding to RalA and PSD-95 controls AMPA receptor endocytosis and LTD. PLoS Biol (2009) 1.05
Simultaneous dual-band optical coherence tomography in the spectral domain for high resolution in vivo imaging. Opt Express (2009) 1.05
IDH mutations as an early and consistent marker in low-grade astrocytomas WHO grade II and their consecutive secondary high-grade gliomas. J Neurooncol (2012) 1.04
Current status of local therapy in malignant gliomas--a clinical review of three selected approaches. Pharmacol Ther (2013) 1.04
Imaging of the three-dimensional alveolar structure and the alveolar mechanics of a ventilated and perfused isolated rabbit lung with Fourier domain optical coherence tomography. J Biomed Opt (2006) 1.04
Function oriented synthesis: the design, synthesis, PKC binding and translocation activity of a new bryostatin analog. Curr Drug Discov Technol (2004) 1.02
Vascular-wall remodeling of 3 human bypass vessels: organ culture and smooth muscle cell properties. J Thorac Cardiovasc Surg (2006) 1.02
Raman spectroscopic imaging for in vivo detection of cerebral brain metastases. Anal Bioanal Chem (2010) 1.01
The role of near-infrared angiography in the assessment of post-operative venous congestion in random pattern, pedicled island and free flaps. Br J Plast Surg (2005) 1.01
Tumor evasion from T cell surveillance. J Biomed Biotechnol (2011) 1.01
Simple and viable in vitro perfusion model for training microvascular anastomoses. Microsurgery (2004) 1.01