Published in Mucosal Immunol on January 25, 2017
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet (2014) 22.33
Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature (1999) 17.72
A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med (2015) 11.05
Health and economic burden of the projected obesity trends in the USA and the UK. Lancet (2011) 10.73
Ghrelin induces adiposity in rodents. Nature (2000) 10.18
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell (1999) 7.56
Multicenter, placebo-controlled trial of lorcaserin for weight management. N Engl J Med (2010) 6.63
Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell (2008) 5.10
Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology (2000) 4.27
Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet (2010) 4.23
Mice lacking ghrelin receptors resist the development of diet-induced obesity. J Clin Invest (2005) 3.92
Effectiveness of primary care-relevant treatments for obesity in adults: a systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med (2011) 3.86
Pneumococcal surface protein A (PspA) is serologically highly variable and is expressed by all clinically important capsular serotypes of Streptococcus pneumoniae. Infect Immun (1990) 3.66
The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab (2002) 3.43
The mitochondrial uncoupling-protein homologues. Nat Rev Mol Cell Biol (2005) 3.42
The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology (2002) 3.17
The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity. J Clin Invest (1968) 3.11
Absence of ghrelin protects against early-onset obesity. J Clin Invest (2005) 2.53
The gut and energy balance: visceral allies in the obesity wars. Science (2005) 2.24
Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science (2010) 2.12
Ghrelin action in the brain controls adipocyte metabolism. J Clin Invest (2006) 2.03
Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. Am J Physiol Gastrointest Liver Physiol (2007) 1.83
Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology (2006) 1.67
Brown fat biology and thermogenesis. Front Biosci (Landmark Ed) (2011) 1.62
Orlistat-associated adverse effects and drug interactions: a critical review. Drug Saf (2008) 1.58
Persistent diet-induced obesity in male C57BL/6 mice resulting from temporary obesigenic diets. PLoS One (2009) 1.48
Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines. Nat Mater (2010) 1.45
Vaccination against weight gain. Proc Natl Acad Sci U S A (2006) 1.45
Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats. Gastroenterology (2005) 1.32
Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats. Neurosci Lett (2003) 1.27
The role of ghrelin and growth hormone secretagogues receptor on rat adipogenesis. Endocrinology (2003) 1.19
Ghrelin induces abdominal obesity via GHS-R-dependent lipid retention. Mol Endocrinol (2009) 1.14
Transgenic mice overexpressing des-acyl ghrelin show small phenotype. Endocrinology (2004) 1.13
Ghrelin regulates adiposity in white adipose tissue and UCP1 mRNA expression in brown adipose tissue in mice. Regul Pept (2005) 1.10
A novel intronic peroxisome proliferator-activated receptor gamma enhancer in the uncoupling protein (UCP) 3 gene as a regulator of both UCP2 and -3 expression in adipocytes. J Biol Chem (2010) 1.04
Altered metabolic and neurochemical responses to chronic unpredictable stressors in ghrelin receptor-deficient mice. Eur J Neurosci (2010) 0.92
The mucosal immune system for vaccine development. Vaccine (2014) 0.90
Nanogel-based PspA intranasal vaccine prevents invasive disease and nasal colonization by Streptococcus pneumoniae. Infect Immun (2013) 0.87
Active immunization against ghrelin decreases weight gain and alters plasma concentrations of growth hormone in growing pigs. Domest Anim Endocrinol (2006) 0.83
The Peptidic GHS-R antagonist [D-Lys(3)]GHRP-6 markedly improves adiposity and related metabolic abnormalities in a mouse model of postmenopausal obesity. Mol Cell Endocrinol (2011) 0.82
Ghrelin vaccination decreases plasma MCP-1 level in LDLR(-/-)-mice. Peptides (2009) 0.82
Standard sample collections for blood ghrelin measurements. Methods Enzymol (2012) 0.82
Safety assessment of FDA-approved (orlistat and lorcaserin) anti-obesity medications. Expert Opin Drug Saf (2015) 0.82
The effect of orlistat, an inhibitor of dietary fat absorption, on the absorption of vitamins A and E in healthy volunteers. J Clin Pharmacol (1996) 0.81
Immunization against active ghrelin using virus-like particles for obesity treatment. Curr Pharm Des (2013) 0.80
Nanogel-based pneumococcal surface protein A nasal vaccine induces microRNA-associated Th17 cell responses with neutralizing antibodies against Streptococcus pneumoniae in macaques. Mucosal Immunol (2015) 0.75