Non-tumor cell IDO1 predominantly contributes to enzyme activity and response to CTLA-4/PD-L1 inhibition in mouse glioblastoma.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28179106)

Published in Brain Behav Immun on February 04, 2017

Authors

Lijie Zhai1, Erik Ladomersky1, Carlos R Dostal2, Kristen L Lauing1, Kathleen Swoap1, Leah K Billingham1, Galina Gritsina1, Meijing Wu1, Robert H McCusker3, David C Binder4, Derek A Wainwright5

Author Affiliations

1: Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
2: Neuroscience Program, The University of Illinois at Urbana-Champaign, Urbana, IL, USA.
3: Department of Animal Sciences, The University of Illinois at Urbana-Champaign, Urbana, IL, USA.
4: Department of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
5: Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Department of Medicine-Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA. Electronic address: derekwainwright@northwestern.edu.

Articles cited by this

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med (2005) 74.55

Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med (2013) 17.53

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. N Engl J Med (2015) 14.71

Prevention of allogeneic fetal rejection by tryptophan catabolism. Science (1998) 9.80

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med (2003) 7.86

CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol (2002) 6.94

Inhibition of T cell proliferation by macrophage tryptophan catabolism. J Exp Med (1999) 5.26

An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol (2010) 3.75

Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. Cancer Res (2007) 3.44

T cell apoptosis by tryptophan catabolism. Cell Death Differ (2002) 3.07

Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain. Cancer Cell (2011) 2.87

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells. Nat Immunol (2011) 2.76

HMGB1 mediates endogenous TLR2 activation and brain tumor regression. PLoS Med (2009) 2.56

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4. J Exp Med (2013) 2.13

IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism. Cancer Immunol Immunother (2008) 1.88

Durable therapeutic efficacy utilizing combinatorial blockade against IDO, CTLA-4, and PD-L1 in mice with brain tumors. Clin Cancer Res (2014) 1.73

Biologic-response-modifier-induced indoleamine 2,3-dioxygenase activity in human peripheral blood mononuclear cell cultures. J Immunol (1987) 1.65

IDO expression in brain tumors increases the recruitment of regulatory T cells and negatively impacts survival. Clin Cancer Res (2012) 1.55

Blocking IDO activity to enhance anti-tumor immunity. Front Biosci (Elite Ed) (2012) 1.46

Molecular Pathways: Targeting IDO1 and Other Tryptophan Dioxygenases for Cancer Immunotherapy. Clin Cancer Res (2015) 1.09

The kynurenine to tryptophan ratio as a prognostic tool for glioblastoma patients enrolling in immunotherapy. J Clin Neurosci (2015) 0.90

Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors. J Med Chem (2015) 0.89

Immunotherapy for cancer in the central nervous system: Current and future directions. Oncoimmunology (2015) 0.88

Improving vaccine efficacy against malignant glioma. Oncoimmunology (2016) 0.81

Immunotherapy for neuro-oncology: the critical rationale for combinatorial therapy. Neuro Oncol (2015) 0.75