Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma.

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Published in N Engl J Med on February 17, 2017


Joaquim Bellmunt1, Ronald de Wit1, David J Vaughn1, Yves Fradet1, Jae-Lyun Lee1, Lawrence Fong1, Nicholas J Vogelzang1, Miguel A Climent1, Daniel P Petrylak1, Toni K Choueiri1, Andrea Necchi1, Winald Gerritsen1, Howard Gurney1, David I Quinn1, Stéphane Culine1, Cora N Sternberg1, Yabing Mai1, Christian H Poehlein1, Rodolfo F Perini1, Dean F Bajorin1, KEYNOTE-045 Investigators

Author Affiliations

1: From Dana-Farber Cancer Institute, Boston (J.B., T.K.C.); Parc de Salut Mar, Hospital del Mar Medical Research Institute, Barcelona (J.B.), and Fundación Instituto Valenciano de Oncología, Valencia (M.A.C.) - both in Spain; Erasmus MC Cancer Institute, Rotterdam (R.W.), and Radboud University Medical Center, Nijmegen (W.G.) - both in the Netherlands; Abramson Cancer Center, University of Pennsylvania, Philadelphia (D.J.V.); Centre Hospitalier Universitaire de Québec-Université Laval, Quebec, QC, Canada (Y.F.); Asan Medical Center and University of Ulsan College of Medicine, Seoul, South Korea (J.-L.L.); the University of California, San Francisco, San Francisco (L.F.); Comprehensive Cancer Centers of Nevada, Las Vegas (N.J.V.); Smilow Cancer Hospital, Yale University, New Haven, CT (D.P.P.); Fondazione IRCCS Istituto Nazionale dei Tumori, Milan (A.N.); Westmead Hospital and Macquarie University, Sydney (H.G.); the University of Southern California Norris Comprehensive Cancer Center and Hospital, Los Angeles (D.I.Q.); Hôpital Saint-Louis, Paris (S.C.); San Camillo and Forlanini Hospitals, Rome (C.N.S.); Merck, Kenilworth, NJ (Y.M., C.H.P., R.F.P.); and Memorial Sloan Kettering Cancer Center, New York (D.F.B.).

Associated clinical trials:

A Study of Pembrolizumab (MK-3475) Versus Paclitaxel, Docetaxel, or Vinflunine for Participants With Advanced Urothelial Cancer (MK-3475-045/KEYNOTE-045) | NCT02256436

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