Targeting Angiogenesis in Biliary Tract Cancers: An Open Option.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28212293)

Published in Int J Mol Sci on February 15, 2017

Authors

Valeria Simone1, Oronzo Brunetti2, Luigi Lupo3, Mario Testini4, Eugenio Maiorano5, Michele Simone6, Vito Longo7, Christian Rolfo8, Marc Peeters9, Aldo Scarpa10,11, Amalia Azzariti12, Antonio Russo13, Domenico Ribatti14,15, Nicola Silvestris16

Author Affiliations

1: Operative Unit of Internal Medicine, Hospital "F.Ferrari", 73042 Casarano (Le), Italy. valeriasimo@gmail.com.
2: Medical Oncology Unit, Cancer Institute "Giovanni Paolo II", 70124 Bari, Italy. dr.oronzo.brunetti@tiscali.it.
3: Department of Emergency and Organ Transplantation, Institute of General Surgery and Liver Transplantation, University of Bari, 70124 Bari, Italy. luigig.lupo@gmail.com.
4: Department of Biomedical Sciences and Human Oncology, Unit of Endocrine, Digestive and Emergency Surgery, 70124 Bari, Italy. mario.testini@uniba.it.
5: Department of Emergency and Organ Transplantation, Operating Unit of Pathological Anatomy, "Aldo Moro" University, 70124 Bari, Italy. eugenio.maiorano@uniba.it.
6: Surgical Oncology Unit, Cancer Institute "Giovanni Paolo II", 70124 Bari, Italy. misimone.67@gmail.com.
7: Medical Oncology Unit, Hospital of Taranto, 74010 Taranto, Italy. vito.longo79@tiscali.it.
8: Phase I-Early Clinical Trials Unit, Oncology Department, Antwerp University Hospital & Center for Oncological Research, 2650 Edegem, Belgium. christian.rolfo@uza.be.
9: Oncology Department, Antwerp University Hospital, 2650 Edegem, Belgium. marc.peeters@uza.be.
10: ARC-NET (Applied Research on Cancer-Network) Research Centre, University of Verona, 37134 Verona, Italy. aldo.scarpa@univr.it.
11: Department of Diagnostics and Public Health, Section of Pathology, University of Verona, 37134 Verona, Italy. aldo.scarpa@univr.it.
12: Preclinical and Clinical Pharmacology Unit, Cancer Institute "Giovanni Paolo II", 70124 Bari, Italy. a.azzariti@oncologico.bari.it.
13: Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, 90144 Palermo, Italy. antonio.russo@usa.net.
14: Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, 70124 Bari, Italy. domenico.ribatti@uniba.it.
15: Cancer Institute "Giovanni Paolo II", 70124 Bari, Italy. domenico.ribatti@uniba.it.
16: Medical Oncology Unit, Cancer Institute "Giovanni Paolo II", 70124 Bari, Italy. n.silvestris@oncologico.bari.it.

Articles cited by this

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol (2002) 17.85

Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med (2010) 15.71

Tumorigenesis and the angiogenic switch. Nat Rev Cancer (2003) 11.95

Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev (2004) 11.69

Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J Biol Chem (1998) 8.30

Nuclear factor-kappaB: the enemy within. Cancer Cell (2004) 6.86

Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene (2002) 6.17

Tumor induction of VEGF promoter activity in stromal cells. Cell (1998) 5.20

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth Factor Rev (2005) 4.65

Exome sequencing of liver fluke-associated cholangiocarcinoma. Nat Genet (2012) 3.63

Guidelines for the diagnosis and treatment of cholangiocarcinoma: an update. Gut (2012) 2.91

VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene (1999) 2.66

Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors. Gastroenterology (2011) 2.63

Multi-institutional phase II study of selumetinib in patients with metastatic biliary cancers. J Clin Oncol (2011) 2.59

Clinical diagnosis and staging of cholangiocarcinoma. Nat Rev Gastroenterol Hepatol (2011) 2.51

Integrative molecular analysis of intrahepatic cholangiocarcinoma reveals 2 classes that have different outcomes. Gastroenterology (2013) 2.42

Efficacy and safety of gemcitabine, oxaliplatin, and bevacizumab in advanced biliary-tract cancers and correlation of changes in 18-fluorodeoxyglucose PET with clinical outcome: a phase 2 study. Lancet Oncol (2009) 2.23

Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers. Nat Genet (2013) 2.15

HCC and angiogenesis: possible targets and future directions. Nat Rev Clin Oncol (2011) 2.10

Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma. Br J Cancer (2007) 2.09

Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma. J Hepatol (2014) 1.67

Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma. Hepatology (2013) 1.65

Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial. Lancet Oncol (2015) 1.63

Expression of two angiogenic factors, vascular endothelial growth factor and platelet-derived endothelial cell growth factor in human pancreatic cancer, and its relationship to angiogenesis. Eur J Cancer (1998) 1.61

Genomic spectra of biliary tract cancer. Nat Genet (2015) 1.58

Identification of CD146 expression, angiogenesis, and lymphangiogenesis as progression, metastasis, and poor-prognosis related markers for gallbladder adenocarcinoma. Tumour Biol (2011) 1.58

Sorafenib in patients with advanced biliary tract carcinoma: a phase II trial. Br J Cancer (2009) 1.54

Nitric oxide in gastrointestinal epithelial cell carcinogenesis: linking inflammation to oncogenesis. Am J Physiol Gastrointest Liver Physiol (2001) 1.52

Report of a multicenter phase II trial testing a combination of biweekly bevacizumab and daily erlotinib in patients with unresectable biliary cancer: a phase II Consortium study. J Clin Oncol (2010) 1.49

Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation. J Biol Chem (2001) 1.44

HIF-1α pathway: role, regulation and intervention for cancer therapy. Acta Pharm Sin B (2015) 1.40

CD146, a multi-functional molecule beyond adhesion. Cancer Lett (2012) 1.36

SWOG 0514: a phase II study of sorafenib in patients with unresectable or metastatic gallbladder carcinoma and cholangiocarcinoma. Invest New Drugs (2011) 1.33

Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance. Oncol Rep (2006) 1.28

Significance of alternatively activated macrophages in patients with intrahepatic cholangiocarcinoma. Cancer Sci (2010) 1.24

Role of tumour-associated macrophages in cancer-related inflammation. Exp Oncol (2010) 1.22

A phase II study of sunitinib as a second-line treatment in advanced biliary tract carcinoma: a multicentre, multinational study. Eur J Cancer (2011) 1.15

Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways. Carcinogenesis (2011) 1.13

Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma. Gut (2011) 1.08

Tumour-associated angiogenesis in human colorectal cancer. Colorectal Dis (2007) 1.08

The prometastatic microenvironment of the liver. Cancer Microenviron (2008) 1.08

Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma. Br J Cancer (2009) 1.08

H3 histamine receptor-mediated activation of protein kinase Calpha inhibits the growth of cholangiocarcinoma in vitro and in vivo. Mol Cancer Res (2009) 1.06

Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis. Hepatology (2004) 1.05

Gemcitabine plus sorafenib versus gemcitabine alone in advanced biliary tract cancer: a double-blind placebo-controlled multicentre phase II AIO study with biomarker and serum programme. Eur J Cancer (2014) 1.04

Comparative protein expression profiles of hilar and peripheral hepatic cholangiocarcinomas. J Hepatol (2009) 1.04

Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis. Int J Cancer (2010) 1.02

S0941: a phase 2 SWOG study of sorafenib and erlotinib in patients with advanced gallbladder carcinoma or cholangiocarcinoma. Br J Cancer (2014) 1.01

A phase II study of gemcitabine and cisplatin plus sorafenib in patients with advanced biliary adenocarcinomas. Br J Cancer (2013) 0.97

Axitinib (AG-013736), an oral specific VEGFR TKI, shows potential therapeutic utility against cholangiocarcinoma. Jpn J Clin Oncol (2014) 0.96

Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cells. J Gastroenterol (2011) 0.96

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors. Hepatology (2015) 0.96

Drug resistance associated with antiangiogenesis therapy. Semin Cancer Biol (2009) 0.95

Vascular endothelial growth factor-C expression in human gallbladder cancer and its relationship to lymph node metastasis. Int J Mol Med (2003) 0.95

Tumor necrosis factor-α promotes the lymphangiogenesis of gallbladder carcinoma through nuclear factor-κB-mediated upregulation of vascular endothelial growth factor-C. Cancer Sci (2014) 0.92

Tumor-associated angiogenesis and lymphangiogenesis correlate with progression of intrahepatic cholangiocarcinoma. Am J Gastroenterol (2009) 0.92

Vascular endothelial growth factor (VEGF) expression in operable gallbladder carcinomas. Eur J Surg Oncol (2003) 0.92

Vascular endothelial growth factor expression is an independent negative predictor in extrahepatic biliary tract carcinomas. Anticancer Res (1999) 0.92

A MEK inhibitor (U0126) prolongs survival in nude mice bearing human gallbladder cancer cells with K-ras mutation: analysis in a novel orthotopic inoculation model. Int J Oncol (2003) 0.91

Cholangiocarcinoma pathogenesis: Role of the tumor microenvironment. Transl Gastrointest Cancer (2012) 0.91

Preclinical evaluation of sorafenib-eluting stent for suppression of human cholangiocarcinoma cells. Int J Nanomedicine (2013) 0.91

Vascular endothelial growth factor-D promotes growth, lymphangiogenesis and lymphatic metastasis in gallbladder cancer. Cancer Lett (2011) 0.91

miR-101 inhibits cholangiocarcinoma angiogenesis through targeting vascular endothelial growth factor (VEGF). Am J Pathol (2013) 0.90

Cholangiocarcinoma: Current Knowledge and New Developments. Gut Liver (2016) 0.89

Evading anti-angiogenic therapy: resistance to anti-angiogenic therapy in solid tumors. Am J Transl Res (2015) 0.87

A randomized, multicenter, phase II study of vandetanib monotherapy versus vandetanib in combination with gemcitabine versus gemcitabine plus placebo in subjects with advanced biliary tract cancer: the VanGogh study. Ann Oncol (2014) 0.86

FOLFIRI plus bevacizumab as a second-line therapy for metastatic intrahepatic cholangiocarcinoma. World J Gastroenterol (2015) 0.86

Lymphangiogenic and angiogentic microvessel density in gallbladder carcinoma. Hepatogastroenterology (2011) 0.82

Microvessel density correlates with lymph node metastases and prognosis in hilar cholangiocarcinoma. J Gastroenterol (2008) 0.82

Angiogenesis in esophageal and gastric cancer: a paradigm shift in treatment. Expert Opin Biol Ther (2014) 0.82

Circulating miR-106a is a Novel Prognostic and Lymph Node Metastasis Indicator for Cholangiocarcinoma. Sci Rep (2015) 0.81

Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-κB pathways in human cholangiocarcinomas both in vitro and in vivo. Oncol Rep (2014) 0.81

[Expressions of VEGF-C and VEGF-D and their correlation with lymphangiogenesis and angiogenesis in gallbladder carcinoma]. Zhonghua Zhong Liu Za Zhi (2010) 0.81

Inhibition of tumor angiogenesis by interferon-γ by suppression of tumor-associated macrophage differentiation. Oncol Res (2014) 0.80

Histamine and histamine receptor regulation of gastrointestinal cancers. Transl Gastrointest Cancer (2012) 0.80

Prognostic impact of vascular endothelial growth factor-A expression in resected gallbladder carcinoma. Tumour Biol (2011) 0.79

Angiopoietin-2 and biliary diseases: elevated serum, but not bile levels are associated with cholangiocarcinoma. PLoS One (2014) 0.79

Differences in immunohistochemical biomarkers between intra- and extrahepatic cholangiocarcinoma: a systematic review and meta-analysis. J Gastroenterol Hepatol (2014) 0.79

Biliary cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol (2016) 0.79

Preclinical activity of EGFR and MEK1/2 inhibitors in the treatment of biliary tract carcinoma. Oncotarget (2016) 0.78

Disease control with sunitinib in advanced intrahepatic cholangiocarcinoma resistant to gemcitabine-oxaliplatin chemotherapy. World J Hepatol (2015) 0.78

Inhibition of carbonic anhydrase potentiates bevacizumab treatment in cholangiocarcinoma. Tumour Biol (2016) 0.78

Second-line chemotherapy in advanced biliary cancer progressed to first-line platinum-gemcitabine combination: a multicenter survey and pooled analysis with published data. J Exp Clin Cancer Res (2015) 0.78

Role of tumor angiogenesis in gallbladder carcinoma: with special reference to thymidine phosphorylase. Int J Clin Oncol (2008) 0.78

Platelet-derived growth factor may be a potential diagnostic and prognostic marker for cholangiocarcinoma. Tumour Biol (2012) 0.78

Prognostic significance of microRNA-203 in cholangiocarcinoma. Int J Clin Exp Pathol (2015) 0.76

Phase I trial of vandetanib in combination with gemcitabine and capecitabine in patients with advanced solid tumors with an expanded cohort in pancreatic and biliary cancers. Invest New Drugs (2015) 0.75