Published in Cell Death Dis on February 23, 2017
REP1 Modulates Autophagy and Macropinocytosis to Enhance Cancer Cell Survival. Int J Mol Sci (2017) 0.75
Stat3 as an oncogene. Cell (1999) 17.39
STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer (2009) 15.45
Cell signaling by receptor tyrosine kinases. Cell (2010) 12.39
Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA (2003) 8.07
EGFR and cancer prognosis. Eur J Cancer (2001) 7.52
Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer. Nat Rev Cancer (2010) 5.82
The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer (2004) 5.47
Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev (2011) 5.20
Endocytosis and intracellular trafficking of ErbBs. Exp Cell Res (2009) 3.70
The quest to overcome resistance to EGFR-targeted therapies in cancer. Nat Med (2013) 3.20
The ERBB network: at last, cancer therapy meets systems biology. Nat Rev Cancer (2012) 2.79
Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase. Science (1993) 2.27
Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Oncogene (2004) 1.95
TAZ is a novel oncogene in non-small cell lung cancer. Oncogene (2011) 1.85
Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling. Oncogene (2007) 1.79
Targeting the ERBB family in cancer: couples therapy. Nat Rev Cancer (2013) 1.72
Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancer. Histochem Cell Biol (2008) 1.65
Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Dev Biol (2009) 1.52
Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential. Oncogene (1997) 1.48
Regulation of EGFR endocytic trafficking by rab proteins. Histol Histopathol (2006) 1.32
Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia. J Clin Invest (2006) 1.29
Mutation of the zebrafish choroideremia gene encoding Rab escort protein 1 devastates hair cells. Proc Natl Acad Sci U S A (2004) 1.29
Mouse choroideremia gene mutation causes photoreceptor cell degeneration and is not transmitted through the female germline. Hum Mol Genet (1997) 1.27
Organization of the Rab-GDI/CHM superfamily: the functional basis for choroideremia disease. Traffic (2001) 1.25
Rab5 isoforms differentially regulate the trafficking and degradation of epidermal growth factor receptors. J Biol Chem (2009) 1.25
Noncell-autonomous photoreceptor degeneration in a zebrafish model of choroideremia. Proc Natl Acad Sci U S A (2007) 1.16
Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma. Nat Rev Cancer (2015) 1.15
Targeting the epidermal growth factor receptor. Br J Cancer (2004) 1.14
Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma. World J Gastroenterol (2008) 1.07
Altered EGFR localization and degradation in human breast cancer cells with an amphiregulin/EGFR autocrine loop. Cell Signal (2008) 1.06
Novel functions for Rab GTPases in multiple aspects of tumour progression. Biochem Soc Trans (2012) 1.04
Rab escort protein 1 (REP1) in intracellular traffic: a functional and pathophysiological overview. Ophthalmic Genet (2004) 1.03
Detection and characterization of point mutations in the choroideremia candidate gene by PCR-SSCP analysis and direct DNA sequencing. Am J Hum Genet (1992) 1.02
Epidermal growth factor-stimulated tyrosine phosphorylation of caveolin-1. Enhanced caveolin-1 tyrosine phosphorylation following aberrant epidermal growth factor receptor status. J Biol Chem (2000) 1.00
Salinomycin induces cell death via inactivation of Stat3 and downregulation of Skp2. Cell Death Dis (2013) 0.98
Modulation of host cell endocytosis by the type III cytotoxin, Pseudomonas ExoS. Traffic (2008) 0.96
Choroideremia gene product affects trophoblast development and vascularization in mouse extra-embryonic tissues. Dev Biol (2004) 0.96
Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase. J Biol Chem (2008) 0.96
Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium. PLoS One (2013) 0.94
EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors. Oncogene (2013) 0.94
Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling. Sci Rep (2013) 0.90
Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment. EMBO J (2012) 0.88
Stat3 induces oncogenic Skp2 expression in human cervical carcinoma cells. Biochem Biophys Res Commun (2012) 0.87
Single choroideremia gene in nonmammalian vertebrates explains early embryonic lethality of the zebrafish model of choroideremia. Invest Ophthalmol Vis Sci (2008) 0.86
RAB7 and TSG101 are required for the constitutive recycling of unliganded EGFRs via distinct mechanisms. Mol Cell Endocrinol (2013) 0.85
Interferon consensus sequence-binding protein (ICSBP) promotes epithelial-to-mesenchymal transition (EMT)-like phenomena, cell-motility, and invasion via TGF-β signaling in U2OS cells. Cell Death Dis (2014) 0.82
EGFR endocytosis is a novel therapeutic target in lung cancer with wild-type EGFR. Oncotarget (2014) 0.79
Quantitative analysis of transcript variants of CHM gene containing LTR12C element in humans. Gene (2011) 0.77
Recent advances and future prospects in choroideremia. Clin Ophthalmol (2015) 0.76
A novel role for flotillin-1 in H-Ras-regulated breast cancer aggressiveness. Int J Cancer (2015) 0.81
REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival. Cell Death Dis (2017) 0.78
Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8. Sci Rep (2017) 0.75