Published in Sci Rep on February 24, 2017
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol (1998) 21.48
Mitochondrial membrane permeabilization in cell death. Physiol Rev (2007) 12.72
NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer (2002) 11.39
Two CD95 (APO-1/Fas) signaling pathways. EMBO J (1998) 10.42
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell (2007) 7.74
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science (2000) 5.22
cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell (2011) 4.78
NF-kappaB signals induce the expression of c-FLIP. Mol Cell Biol (2001) 4.55
The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol Cell (2011) 4.43
Radical-free biology of oxidative stress. Am J Physiol Cell Physiol (2008) 4.33
Targeting IAP proteins for therapeutic intervention in cancer. Nat Rev Drug Discov (2012) 3.88
Thioredoxin and related molecules--from biology to health and disease. Antioxid Redox Signal (2007) 3.50
Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity (2013) 3.22
Necroptosis and its role in inflammation. Nature (2015) 3.01
Mechanisms of necroptosis in T cells. J Exp Med (2011) 2.51
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med (2006) 2.35
Redox regulation of NF-kappaB activation: distinct redox regulation between the cytoplasm and the nucleus. Antioxid Redox Signal (2005) 2.16
Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer. Structure (1996) 2.07
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death. Nat Rev Mol Cell Biol (2013) 1.89
Mammalian mitochondrial IAP binding proteins. Biochem Biophys Res Commun (2003) 1.79
Stoichiometry of the CD95 death-inducing signaling complex: experimental and modeling evidence for a death effector domain chain model. Mol Cell (2012) 1.57
The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. Mol Cell (2013) 1.54
High-throughput detection and multiplex identification of cell contaminations. Nucleic Acids Res (2009) 1.49
Dimethylfumarate is a potent inducer of apoptosis in human T cells. J Invest Dermatol (2003) 1.49
Dimethylfumarate inhibits TNF-induced nuclear entry of NF-kappa B/p65 in human endothelial cells. J Immunol (2002) 1.39
Targeting NF-kappaB in hematologic malignancies. Cell Death Differ (2006) 1.38
Phase II trial of proteasome inhibitor bortezomib in patients with relapsed or refractory cutaneous T-cell lymphoma. J Clin Oncol (2007) 1.35
Down-regulating constitutive activation of the NF-kappaB canonical pathway overcomes the resistance of cutaneous T-cell lymphoma to apoptosis. Blood (2005) 1.34
Regulation of the catalytic activity and structure of human thioredoxin 1 via oxidation and S-nitrosylation of cysteine residues. J Biol Chem (2008) 1.32
Dimethylfumarate for psoriasis: more than a dietary curiosity. Trends Mol Med (2005) 1.31
Transcription factor NF-kappaB is constitutively activated in acute lymphoblastic leukemia cells. Leukemia (2000) 1.23
Redox regulation of nuclear post-translational modifications during NF-kappaB activation. Antioxid Redox Signal (2009) 1.21
Rearranged NFKB2 gene in the HUT78 T-lymphoma cell line codes for a constitutively nuclear factor lacking transcriptional repressor functions. Oncogene (1994) 1.20
Loss of androgen receptor expression promotes a stem-like cell phenotype in prostate cancer through STAT3 signaling. Cancer Res (2013) 1.13
Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis. Cell Death Differ (2015) 1.11
Human thioredoxin homodimers: regulation by pH, role of aspartate 60, and crystal structure of the aspartate 60 --> asparagine mutant. Biochemistry (1997) 1.10
Inhibition of constitutively activated nuclear factor-kappaB induces reactive oxygen species- and iron-dependent cell death in cutaneous T-cell lymphoma. Cancer Res (2009) 1.06
The Ripoptosome: death decision in the cytosol. Mol Cell (2011) 1.04
Curcumin selectively induces apoptosis in cutaneous T-cell lymphoma cell lines and patients' PBMCs: potential role for STAT-3 and NF-kappaB signaling. J Invest Dermatol (2010) 1.01
Cytokine induced expression of porcine inhibitor of apoptosis protein (iap) family member is regulated by NF-kappa B. Biochem Biophys Res Commun (1998) 1.00
Oxidative inactivation of thioredoxin as a cellular growth factor and protection by a Cys73-->Ser mutation. Biochem Pharmacol (1996) 0.93
Aquaria: simplifying discovery and insight from protein structures. Nat Methods (2015) 0.91
Thioredoxin-1 and posttranslational modifications. Antioxid Redox Signal (2006) 0.91
Thioredoxin redox western analysis. Curr Protoc Toxicol (2009) 0.90
Nonsteroidal anti-inflammatory drugs induce apoptosis in cutaneous T-cell lymphoma cells and enhance their sensitivity for TNF-related apoptosis-inducing ligand. J Invest Dermatol (2011) 0.90
PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-kappaB-dependent proinflammatory activation of alveolar epithelial cells. Br J Pharmacol (2008) 0.87
Dimethylfumarate inhibits nuclear binding of nuclear factor kappaB but not of nuclear factor of activated T cells and CCAAT/enhancer binding protein beta in activated human T cells. Br J Dermatol (2007) 0.86
Dimethyl fumarate restores apoptosis sensitivity and inhibits tumor growth and metastasis in CTCL by targeting NF-κB. Blood (2016) 0.83
Cutaneous T-cell lymphoma: a paradigm for biological therapies. Leuk Lymphoma (2004) 0.81
Interferon-α abrogates the suppressive effect of apoptotic cells on dendritic cells in an in vitro model of systemic lupus erythematosus pathogenesis. J Rheumatol (2013) 0.80