The Role of Carbohydrate Response Element Binding Protein in Intestinal and Hepatic Fructose Metabolism.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28241431)

Published in Nutrients on February 22, 2017

Authors

Katsumi Iizuka1,2

Author Affiliations

1: Department of Diabetes and Endocrinology, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan. kiizuka@gifu-u.ac.jp.
2: Gifu University Hospital Center for Nutritional Support and Infection Control, Gifu 501-1194, Japan. kiizuka@gifu-u.ac.jp.

Articles cited by this

A diet low in FODMAPs reduces symptoms of irritable bowel syndrome. Gastroenterology (2013) 8.37

Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr (2002) 5.13

A glucose-responsive transcription factor that regulates carbohydrate metabolism in the liver. Proc Natl Acad Sci U S A (2001) 4.73

Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Cell Metab (2006) 4.02

Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev (2010) 3.60

Glucose and cAMP regulate the L-type pyruvate kinase gene by phosphorylation/dephosphorylation of the carbohydrate response element binding protein. Proc Natl Acad Sci U S A (2001) 3.57

Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci U S A (2004) 3.54

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature (2012) 3.35

Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver. Proc Natl Acad Sci U S A (2003) 3.27

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metab (2008) 2.76

Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase. J Biol Chem (2001) 2.74

ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver. J Biol Chem (2006) 2.50

Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice. Diabetes (2006) 2.43

Carbohydrate response element binding protein directly promotes lipogenic enzyme gene transcription. Proc Natl Acad Sci U S A (2004) 2.29

Regulation of the fructose transporter GLUT5 in health and disease. Am J Physiol Endocrinol Metab (2008) 1.92

Glucose-stimulated expression of Txnip is mediated by carbohydrate response element-binding protein, p300, and histone H4 acetylation in pancreatic beta cells. J Biol Chem (2009) 1.82

Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes. J Biol Chem (2004) 1.80

Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proc Natl Acad Sci U S A (2012) 1.72

FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver. Cell Metab (2015) 1.68

FGF21 Regulates Sweet and Alcohol Preference. Cell Metab (2015) 1.66

Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module. Diabetes (2006) 1.61

Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice. Am J Physiol Endocrinol Metab (2006) 1.61

A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. Nat Cell Biol (2016) 1.50

Fructose induced lipogenesis: from sugar to fat to insulin resistance. Trends Endocrinol Metab (2010) 1.43

Glucose as a regulator of eukaryotic gene transcription. Trends Endocrinol Metab (2005) 1.40

Diabetes regulates fructose absorption through thioredoxin-interacting protein. Elife (2016) 1.39

Increased fructose concentrations in blood and urine in patients with diabetes. Diabetes Care (2002) 1.38

Novel insights into ChREBP regulation and function. Trends Endocrinol Metab (2013) 1.38

WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network. Hum Mol Genet (2001) 1.37

Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes. FEBS Lett (2009) 1.31

O-GlcNAcylation increases ChREBP protein content and transcriptional activity in the liver. Diabetes (2011) 1.28

Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme. J Histochem Cytochem (2009) 1.27

Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression. PLoS One (2011) 1.27

Fructose ingestion acutely stimulates circulating FGF21 levels in humans. Mol Metab (2014) 1.26

Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension. J Biol Chem (2008) 1.25

Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver. PLoS One (2012) 1.24

Glucose controls nuclear accumulation, promoter binding, and transcriptional activity of the MondoA-Mlx heterodimer. Mol Cell Biol (2010) 1.22

Fructose-mediated non-enzymatic glycation: sweet coupling or bad modification. Diabetes Metab Res Rev (2004) 1.22

The role of fructose transporters in diseases linked to excessive fructose intake. J Physiol (2012) 1.21

De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health. Nat Commun (2013) 1.20

Fructose metabolism in humans - what isotopic tracer studies tell us. Nutr Metab (Lond) (2012) 1.12

Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP). Biochem Biophys Res Commun (2010) 1.10

Intestinal absorption of fructose in the rat. Gastroenterology (1991) 1.10

The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions. Am J Physiol Endocrinol Metab (2006) 1.07

Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver. J Hepatol (2011) 1.05

Thioredoxin/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases. Front Immunol (2014) 1.04

Fructose malabsorption and intolerance: effects of fructose with and without simultaneous glucose ingestion. Crit Rev Food Sci Nutr (2011) 0.96

Structure and alternative splicing of the ketohexokinase gene. Eur J Biochem (1998) 0.93

Glucose and thyroid hormone co-regulate the expression of the intestinal fructose transporter GLUT5. Biochem J (1999) 0.88

Eucalyptus leaf extract suppresses the postprandial elevation of portal, cardiac and peripheral fructose concentrations after sucrose ingestion in rats. J Clin Biochem Nutr (2010) 0.88

Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes. Biochem J (2012) 0.86

Hepatic FoxO1 integrates glucose utilization and lipid synthesis through regulation of Chrebp O-glycosylation. PLoS One (2012) 0.86

Fructose-induced increases in expression of intestinal fructolytic and gluconeogenic genes are regulated by GLUT5 and KHK. Am J Physiol Regul Integr Comp Physiol (2015) 0.84

Metabolite regulation of nucleo-cytosolic trafficking of carbohydrate response element-binding protein (ChREBP): role of ketone bodies. J Biol Chem (2013) 0.84

Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2. Biochem J (2003) 0.84

Fructose malabsorption. Mol Cell Pediatr (2016) 0.83

Feedback looping between ChREBP and PPARα in the regulation of lipid metabolism in brown adipose tissues. Endocr J (2013) 0.83

Transport, metabolism, and endosomal trafficking-dependent regulation of intestinal fructose absorption. FASEB J (2015) 0.83

Role of glucose-6-phosphate and xylulose-5-phosphate in the regulation of glucose-stimulated gene expression in the pancreatic β cell line, INS-1E. Endocr J (2012) 0.82

The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis. Trends Endocrinol Metab (2016) 0.81

ChREBP regulates fructose-induced glucose production independently of insulin signaling. J Clin Invest (2016) 0.80

Genome-Wide Analysis of ChREBP Binding Sites on Male Mouse Liver and White Adipose Chromatin. Endocrinology (2015) 0.80

A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism. Mol Metab (2016) 0.78

Diabetic Cardiomyopathy: The Case for a Role of Fructose in Disease Etiology. Diabetes (2016) 0.78

Triiodothyronine (T3) and fructose coordinately enhance expression of the GLUT5 gene in the small intestine of rats during weaning period. Biosci Biotechnol Biochem (2007) 0.77

Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation. Biochem Biophys Res Commun (2015) 0.77

Rat glucagon receptor mRNA is directly regulated by glucose through transactivation of the carbohydrate response element binding protein. Biochem Biophys Res Commun (2011) 0.77

Islet ChREBP-β is increased in diabetes and controls ChREBP-α and glucose-induced gene expression via a negative feedback loop. Mol Metab (2016) 0.76

A review of recent evidence relating to sugars, insulin resistance and diabetes. Eur J Nutr (2016) 0.76

Is fructose malabsorption a cause of irritable bowel syndrome? Med Hypotheses (2015) 0.76

FGF21 and metabolic disease in 2016: A new frontier in FGF21 biology. Nat Rev Endocrinol (2016) 0.76

Metabolite Regulation of Nuclear Localization of Carbohydrate-response Element-binding Protein (ChREBP): ROLE OF AMP AS AN ALLOSTERIC INHIBITOR. J Biol Chem (2016) 0.76

Keeping tabs on fructose. Elife (2016) 0.76

The transcription factor carbohydrate-response element-binding protein (ChREBP): A possible link between metabolic disease and cancer. Biochim Biophys Acta (2016) 0.76

Controversies about sugars: results from systematic reviews and meta-analyses on obesity, cardiometabolic disease and diabetes. Eur J Nutr (2016) 0.75