Effect of overall phenotypic selection on genetic change at individual loci.

PubWeight™: 3.41‹?› | Rank: Top 1%

🔗 View Article (PMC 393140)

Published in Proc Natl Acad Sci U S A on December 01, 1978

Authors

M Kimura, J F Crow

Articles citing this

Comparing evolvability and variability of quantitative traits. Genetics (1992) 10.50

Selection in the evolution of gene duplications. Genome Biol (2002) 5.58

Pleiotropic models of quantitative variation. Genetics (1990) 4.42

Comparative evolutionary rates of introns and exons in murine rodents. J Mol Evol (1997) 2.75

Deleterious mutations, apparent stabilizing selection and the maintenance of quantitative variation. Genetics (1992) 2.59

Possibility of extensive neutral evolution under stabilizing selection with special reference to nonrandom usage of synonymous codons. Proc Natl Acad Sci U S A (1981) 2.23

The consequences of fluctuating selection for isozyme polymorphisms in Daphnia. Genetics (1987) 2.14

Efficiency of truncation selection. Proc Natl Acad Sci U S A (1979) 2.00

Selective sweep at a quantitative trait locus in the presence of background genetic variation. Genetics (2008) 1.86

Genome-wide effects of long-term divergent selection. PLoS Genet (2010) 1.82

Multidimensional epistasis and the disadvantage of sex. Proc Natl Acad Sci U S A (2001) 1.56

Gene duplication and the origin of novel proteins. Proc Natl Acad Sci U S A (2005) 1.47

Selection for high and low virulence in the malaria parasite Plasmodium chabaudi. Proc Biol Sci (1999) 1.31

The statistics of bulk segregant analysis using next generation sequencing. PLoS Comput Biol (2011) 1.27

Integrating evolutionary and functional approaches to infer adaptation at specific loci. Evolution (2010) 1.21

On the quantitative genetics of mixture characters. Genetics (2006) 1.13

Cliff-edge model of obstetric selection in humans. Proc Natl Acad Sci U S A (2016) 1.07

Local fitness landscape of the green fluorescent protein. Nature (2016) 0.96

Geographical variation in a quantitative character. Genetics (1994) 0.94

Epistasis Is a Major Determinant of the Additive Genetic Variance in Mimulus guttatus. PLoS Genet (2015) 0.92

Polygenic mutation in Drosophila melanogaster: Mapping spontaneous mutations affecting sensory bristle number. Genetics (2005) 0.89

Measuring natural selection on genotypes and phenotypes in the wild. Cold Spring Harb Symp Quant Biol (2010) 0.86

Rate of evolution of a quantitative character. Proc Natl Acad Sci U S A (1992) 0.79

A finite locus effect diffusion model for the evolution of a quantitative trait. J Math Biol (2006) 0.79

An alternative to the breeder's and Lande's equations. G3 (Bethesda) (2014) 0.75

Natural selection opposing artificial selection: a two-locus deterministic simulation. Genetics (1981) 0.75

Substitution rates under stabilizing selection. Genetics (1987) 0.75

Selection limits and strategies. Proc Natl Acad Sci U S A (1980) 0.75

What drives the evolution of condition-dependent recombination in diploids? Some insights from simulation modelling. Philos Trans R Soc Lond B Biol Sci (2017) 0.75

The Genomic Architecture of Flowering Time Varies Across Space and Time in Mimulus guttatus. Genetics (2017) 0.75

Articles by these authors

(truncated to the top 100)

A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences. J Mol Evol (1980) 113.75

Evolutionary rate at the molecular level. Nature (1968) 33.15

AN ESTIMATE OF THE MUTATIONAL DAMAGE IN MAN FROM DATA ON CONSANGUINEOUS MARRIAGES. Proc Natl Acad Sci U S A (1956) 23.27

The number of heterozygous nucleotide sites maintained in a finite population due to steady flux of mutations. Genetics (1969) 22.59

Rates of spontaneous mutation. Genetics (1998) 14.89

A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population. Genet Res (1973) 13.08

Mutation rate and dominance of genes affecting viability in Drosophila melanogaster. Genetics (1972) 12.05

Mutations affecting fitness in Drosophila populations. Annu Rev Genet (1977) 9.39

A Comparison of the Effect of Lethal and Detrimental Chromosomes from Drosophila Populations. Genetics (1960) 9.38

A stochastic model concerning the maintenance of genetic variability in quantitative characters. Proc Natl Acad Sci U S A (1965) 9.20

Obesity, cigarette smoking, and telomere length in women. Lancet (2005) 8.59

Artemisinins target the SERCA of Plasmodium falciparum. Nature (2003) 7.72

The substitutional load in a finite population. Heredity (Edinb) (1969) 7.56

Linkage disequilibrium at steady state determined by random genetic drift and recurrent mutation. Genetics (1969) 7.33

Group selection for a polygenic behavioral trait: estimating the degree of population subdivision. Proc Natl Acad Sci U S A (1984) 7.04

The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell (2006) 6.80

Protein polymorphism as a phase of molecular evolution. Nature (1971) 6.68

Theoretical foundation of population genetics at the molecular level. Theor Popul Biol (1971) 6.38

The probability of consanguineous marriages. Genetics (1966) 5.85

Estimation of evolutionary distances between homologous nucleotide sequences. Proc Natl Acad Sci U S A (1981) 5.34

On the stochastic model for estimation of mutational distance between homologous proteins. J Mol Evol (1972) 5.16

Evidence for sperm dysfunction as the mechanism of segregation distortion in Drosophila melanogaster. Proc Natl Acad Sci U S A (1967) 5.03

Heterozygous Effects on Viability, Fertility, Rate of Development, and Longevity of Drosophila Chromosomes That Are Lethal When Homozygous. Genetics (1960) 5.00

On some principles governing molecular evolution. Proc Natl Acad Sci U S A (1974) 4.97

Multilayer white light-emitting organic electroluminescent device. Science (1995) 4.86

Genetic variability maintained in a finite population due to mutational production of neutral and nearly neutral isoalleles. Genet Res (1968) 4.83

The rate of molecular evolution considered from the standpoint of population genetics. Proc Natl Acad Sci U S A (1969) 4.75

Pattern of neutral polymorphism in a geographically structured population. Genet Res (1971) 4.65

On the constancy of the evolutionary rate of cistrons. J Mol Evol (1971) 4.49

The age of a neutral mutant persisting in a finite population. Genetics (1973) 4.44

Genetic variability and effective population size when local extinction and recolonization of subpopulations are frequent. Proc Natl Acad Sci U S A (1980) 4.37

The basal ganglia and adaptive motor control. Science (1994) 4.27

The influence of epistasis on homozygous viability depression in Drosophila melanogaster. Genetics (1969) 4.25

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol (2011) 4.22

Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension (2001) 4.07

The genetic variance for viability and its components in a local population of Drosophila melanogaster. Genetics (1974) 4.04

Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution. Nature (1977) 4.00

Development of a pertussis component vaccine in Japan. Lancet (1984) 3.94

Measurement of inbreeding from the frequency of marriages between persons of the same surname. Eugen Q (1965) 3.88

Haploidy or diploidy: which is better? Nature (1991) 3.76

Distribution of allelic frequencies in a finite population under stepwise production of neutral alleles. Proc Natl Acad Sci U S A (1975) 3.64

Linkage disequilibrium between two segregating nucleotide sites under the steady flux of mutations in a finite population. Genetics (1971) 3.51

The average number of generations until extinction of an individual mutant gene in a finite population. Genetics (1969) 3.49

Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell (2006) 3.44

Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension (2000) 3.32

Stepwise mutation model and distribution of allelic frequencies in a finite population. Proc Natl Acad Sci U S A (1978) 3.29

Mutation and evolution at the molecular level. Genetics (1973) 2.79

On quasilinkage equilibrium and the fundamental theorem of natural selection. Theor Popul Biol (1970) 2.77

A molecular approach to estimating the human deleterious mutation rate. Hum Mutat (1993) 2.76

Fixation of a deleterious allele at one of two "duplicate" loci by mutation pressure and random drift. Proc Natl Acad Sci U S A (1979) 2.51

Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast. Cancer Res (1999) 2.28

Continuous selective models. Theor Popul Biol (1974) 2.27

Possibility of extensive neutral evolution under stabilizing selection with special reference to nonrandom usage of synonymous codons. Proc Natl Acad Sci U S A (1981) 2.23

Molecular clock of viral evolution, and the neutral theory. Proc Natl Acad Sci U S A (1990) 2.15

Responses of tonically active neurons in the primate's striatum undergo systematic changes during behavioral sensorimotor conditioning. J Neurosci (1994) 2.14

Sequence variation in the 18S rRNA gene, a target for PCR-based malaria diagnosis, in Plasmodium ovale from southern Vietnam. J Clin Microbiol (1996) 2.12

Structural analysis of the dnaA and dnaN genes of Escherichia coli. Gene (1984) 2.11

Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behçet disease. Proc Natl Acad Sci U S A (1997) 2.10

Group selection for a polygenic behavioral trait: a differential proliferation model. Proc Natl Acad Sci U S A (1982) 2.08

The length of time required for a selectively neutral mutant to reach fixation through random frequency drift in a finite population. Genet Res (1970) 2.05

A gene-counting method of maximum likelihood for estimating gene frequencies in ABO and ABO-like systems. Ann Hum Genet (1968) 2.05

Efficiency of truncation selection. Proc Natl Acad Sci U S A (1979) 2.00

Selective constraint in protein polymorphism: study of the effectively neutral mutation model by using an improved pseudosampling method. Proc Natl Acad Sci U S A (1983) 1.98

Details of an isolation method for hepatic lymphocytes in mice. J Immunol Methods (1992) 1.97

The effect of selected linked locus on heterozygosity of neutral alleles (the hitch-hiking effect). Genet Res (1975) 1.95

Neurons in the thalamic CM-Pf complex supply striatal neurons with information about behaviorally significant sensory events. J Neurophysiol (2001) 1.94

High prevalence of Plasmodium malariae and Plasmodium ovale in malaria patients along the Thai-Myanmar border, as revealed by acridine orange staining and PCR-based diagnoses. Trop Med Int Health (1998) 1.93

Alternative fitness models with the same allele frequency dynamics. Genetics (1990) 1.88

Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Valpha14 natural killer T cells. J Exp Med (1999) 1.88

New approach to cell lineage analysis in mammals using the Cre-loxP system. Mol Reprod Dev (2000) 1.88

Eukaryotes-prokaryotes divergence estimated by 5S ribosomal RNA sequences. Nat New Biol (1973) 1.88

Functional organization of genetic material as a product of molecular evolution. Nature (1971) 1.79

Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. J Biol Chem (1996) 1.72

Longitudinal versus cross-sectional evaluations of leukocyte telomere length dynamics: age-dependent telomere shortening is the rule. J Gerontol A Biol Sci Med Sci (2011) 1.72

Behavior of neutral mutants influenced by asociated overdominant loci in finite populations. Genetics (1971) 1.68

Drug-sensitivity of El Tor vibrio strains isolated in the Philippines in 1964 and 1965. Bull World Health Organ (1967) 1.67

Genetic evidence for the effect of a postglacial population expansion on the phylogeography of a North American songbird. Proc Biol Sci (2000) 1.66

Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma. Oncogene (2010) 1.65

Probability of fixation of a mutant gene in a finite population when selective advantage decreases with time. Genetics (1970) 1.65

Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene. Hum Mol Genet (1999) 1.60

Development of associative overdominance through linkage disequilibrium in finite populations. Genet Res (1970) 1.59

Self-regeneration of a Pd-perovskite catalyst for automotive emissions control. Nature (2002) 1.58

A model of evolutionary base substitutions and its application with special reference to rapid change of pseudogenes. Genetics (1981) 1.57

Genome-wide profiling of promoter methylation in human. Oncogene (2006) 1.55

Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis. Osteoporos Int (2007) 1.55

Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase beta. J Biol Chem (1999) 1.54

Telaprevir impairs renal function and increases blood ribavirin concentration during telaprevir/pegylated interferon/ribavirin therapy for chronic hepatitis C. J Viral Hepat (2014) 1.54

Conversion of normal behavior to shiverer by myelin basic protein antisense cDNA in transgenic mice. Science (1988) 1.53

Supernormal histamine release and normal cytotoxic activity of beige (Chédiak-Higashi syndrome) rat mast cells with giant granules. Int Arch Allergy Immunol (1993) 1.53

Probability of gene fixation in an expanding finite population. Proc Natl Acad Sci U S A (1974) 1.52

Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci U S A (1997) 1.52

Temporal and spatial characteristics of tonically active neurons of the primate's striatum. J Neurophysiol (1995) 1.52

Shortened telomere length in white blood cells of patients with IDDM. Diabetes (1998) 1.52

Bystander effect-mediated therapy of experimental brain tumor by genetically engineered tumor cells. Hum Gene Ther (1998) 1.51

A kinematic analysis of walking and physical fitness testing in elderly women. Can J Sport Sci (1991) 1.51

Effect of the nigrostriatal dopamine system on acquired neural responses in the striatum of behaving monkeys. Science (1994) 1.50

Sequence variation in the small-subunit rRNA gene of Plasmodium malariae and prevalence of isolates with the variant sequence in Sichuan, China. J Clin Microbiol (1998) 1.49

Organization of cat visual cortex as investigated by cross-correlation technique. J Neurophysiol (1981) 1.48

A new allele of the lpr locus, lprcg, that complements the gld gene in induction of lymphadenopathy in the mouse. J Exp Med (1990) 1.48

The features of causes of death in Japanese diabetics during the period 1971-1980. Tohoku J Exp Med (1983) 1.48