A safe packaging line for gene transfer: separating viral genes on two different plasmids.

PubWeight™: 7.87‹?› | Rank: Top 0.1%

🔗 View Article (PMC 253118)

Published in J Virol on April 01, 1988

Authors

D Markowitz1, S Goff, A Bank

Author Affiliations

1: Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032.

Articles citing this

(truncated to the top 100)

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res (1990) 20.53

A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc Natl Acad Sci U S A (1996) 8.53

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis. EMBO J (1994) 8.02

A transient three-plasmid expression system for the production of high titer retroviral vectors. Nucleic Acids Res (1995) 7.08

The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. J Virol (1996) 6.62

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J (1998) 5.21

Identification of a signal in a murine retrovirus that is sufficient for packaging of nonretroviral RNA into virions. J Virol (1988) 4.88

A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes. Proc Natl Acad Sci U S A (1994) 4.86

Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J (1996) 4.26

Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection. J Exp Med (1993) 3.29

pH-independent murine leukemia virus ecotropic envelope-mediated cell fusion: implications for the role of the R peptide and p12E TM in viral entry. J Virol (1994) 2.87

New retrovirus helper cells with almost no nucleotide sequence homology to retrovirus vectors. J Virol (1989) 2.86

PML, a growth suppressor disrupted in acute promyelocytic leukemia. Mol Cell Biol (1994) 2.68

Repression of cyclin D1: a novel function of MYC. Mol Cell Biol (1994) 2.67

Active immunotherapy of cancer with a nonreplicating recombinant fowlpox virus encoding a model tumor-associated antigen. J Immunol (1995) 2.45

Programmed cell death and Bcl-2 protection in the absence of a nucleus. EMBO J (1994) 2.43

Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity. J Exp Med (1990) 2.41

Type C retrovirus inactivation by human complement is determined by both the viral genome and the producer cell. J Virol (1994) 2.36

Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt. Mol Cell Biol (1998) 2.28

Resistance to virus infection conferred by the interferon-induced promyelocytic leukemia protein. J Virol (1998) 2.26

Packaging of human immunodeficiency virus type 1 RNA requires cis-acting sequences outside the 5' leader region. J Virol (1993) 2.15

Analysis of the functional and host range-determining regions of the murine ectropic and amphotropic retrovirus envelope proteins. J Virol (1993) 2.12

Helper virus induced T cell lymphoma in nonhuman primates after retroviral mediated gene transfer. J Exp Med (1992) 2.12

Formation of infectious hybrid virions with gibbon ape leukemia virus and human T-cell leukemia virus retroviral envelope glycoproteins and the gag and pol proteins of Moloney murine leukemia virus. J Virol (1989) 2.11

Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor. EMBO J (1994) 2.02

A chromatin insulator protects retrovirus vectors from chromosomal position effects. Proc Natl Acad Sci U S A (2000) 1.97

Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments. EMBO J (1998) 1.96

Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. EMBO J (1995) 1.92

Multiple modifications in cis elements of the long terminal repeat of retroviral vectors lead to increased expression and decreased DNA methylation in embryonic carcinoma cells. J Virol (1995) 1.90

The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. J Exp Med (2004) 1.90

Expression cloning of oncogenes by retroviral transfer of cDNA libraries. Mol Cell Biol (1995) 1.89

LIGHT, a novel ligand for lymphotoxin beta receptor and TR2/HVEM induces apoptosis and suppresses in vivo tumor formation via gene transfer. J Clin Invest (1998) 1.89

Retroviral integration within the Fli-2 locus results in inactivation of the erythroid transcription factor NF-E2 in Friend erythroleukemias: evidence that NF-E2 is essential for globin expression. Proc Natl Acad Sci U S A (1994) 1.84

Binding kinetics of ecotropic (Moloney) murine leukemia retrovirus with NIH 3T3 cells. J Virol (1995) 1.82

Generation of targeted retroviral vectors by using single-chain variable fragment: an approach to in vivo gene delivery. Proc Natl Acad Sci U S A (1995) 1.80

An internal ribosomal entry mechanism promotes translation of murine leukemia virus gag polyprotein precursors. J Virol (1995) 1.80

The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions. J Cell Biol (1996) 1.79

NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice. EMBO J (2001) 1.78

Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus. J Exp Med (1992) 1.74

The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes Dev (2000) 1.74

Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation. J Cell Biol (2001) 1.73

Expression of human alpha 1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes. Proc Natl Acad Sci U S A (1992) 1.72

Promoter interactions in retrovirus vectors introduced into fibroblasts and embryonic stem cells. J Virol (1991) 1.72

Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing. Proc Natl Acad Sci U S A (1992) 1.72

Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins. Proc Natl Acad Sci U S A (1991) 1.71

Functional characterization of a U5 ribozyme: intracellular suppression of human immunodeficiency virus type 1 expression. J Virol (1992) 1.68

Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J Clin Invest (2001) 1.66

Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells. EMBO J (2002) 1.66

Retroviral vectors containing putative internal ribosome entry sites: development of a polycistronic gene transfer system and applications to human gene therapy. Nucleic Acids Res (1992) 1.66

Targeted and highly efficient gene transfer into CD4+ cells by a recombinant human immunodeficiency virus retroviral vector. J Clin Invest (1991) 1.64

Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal. EMBO J (1994) 1.64

Genetic rearrangements occurring during a single cycle of murine leukemia virus vector replication: characterization and implications. J Virol (1995) 1.62

Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene. EMBO J (1993) 1.61

Role of p120 Ras-GAP in directed cell movement. J Cell Biol (2000) 1.59

Development of a high-titer retrovirus producer cell line capable of gene transfer into rhesus monkey hematopoietic stem cells. Proc Natl Acad Sci U S A (1990) 1.59

Determination of the site of first strand transfer during Moloney murine leukemia virus reverse transcription and identification of strand transfer-associated reverse transcriptase errors. EMBO J (1997) 1.54

Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase. Mol Cell Biol (1996) 1.50

Inducible human immunodeficiency virus type 1 packaging cell lines. J Virol (1996) 1.49

Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells. EMBO J (1995) 1.48

Somatic cell mutants resistant to retrovirus replication: intracellular blocks during the early stages of infection. Mol Biol Cell (1999) 1.47

Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron. Mol Cell Biol (1995) 1.47

Clonal analysis of stably transduced human epidermal stem cells in culture. Proc Natl Acad Sci U S A (1996) 1.44

Independent expression of the transforming amino-terminal domain of SV40 large I antigen from an alternatively spliced third SV40 early mRNA. EMBO J (1993) 1.39

Stable alphavirus packaging cell lines for Sindbis virus and Semliki Forest virus-derived vectors. Proc Natl Acad Sci U S A (1999) 1.38

A new avian leukosis virus-based packaging cell line that uses two separate transcomplementing helper genomes. J Virol (1990) 1.38

Transduction of nondividing human macrophages with gammaretrovirus-derived vectors. J Virol (2006) 1.38

Consistent, persistent expression from modified retroviral vectors in murine hematopoietic stem cells. Proc Natl Acad Sci U S A (1998) 1.37

Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail. Proc Natl Acad Sci U S A (1995) 1.37

The beta-PDGF receptor induces neuronal differentiation of PC12 cells. Mol Biol Cell (1992) 1.36

Expression of human adenosine deaminase in murine hematopoietic cells. Mol Cell Biol (1988) 1.35

Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain. J Exp Med (1993) 1.35

Truncation of the human immunodeficiency virus type 1 envelope glycoprotein allows efficient pseudotyping of Moloney murine leukemia virus particles and gene transfer into CD4+ cells. J Virol (1997) 1.34

The Myc negative autoregulation mechanism requires Myc-Max association and involves the c-myc P2 minimal promoter. Mol Cell Biol (1997) 1.33

E- vectors: development of novel self-inactivating and self-activating retroviral vectors for safer gene therapy. J Virol (1995) 1.32

Unusually high frequency of reconstitution of long terminal repeats in U3-minus retrovirus vectors by DNA recombination or gene conversion. J Virol (1992) 1.32

Inhibition of human immunodeficiency virus type 1 replication by regulated expression of a polymeric Tat activation response RNA decoy as a strategy for gene therapy in AIDS. Proc Natl Acad Sci U S A (1993) 1.29

Mutagenesis analysis of the murine leukemia virus matrix protein: identification of regions important for membrane localization and intracellular transport. J Virol (1997) 1.28

A novel mechanism of retrovirus inactivation in human serum mediated by anti-alpha-galactosyl natural antibody. J Exp Med (1995) 1.28

Phenotypic correction of factor IX deficiency in skin fibroblasts of hemophilic dogs. Proc Natl Acad Sci U S A (1990) 1.28

Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth development. Proc Natl Acad Sci U S A (2000) 1.28

Characterization of replication-competent retroviruses from nonhuman primates with virus-induced T-cell lymphomas and observations regarding the mechanism of oncogenesis. J Virol (1994) 1.28

PML suppresses oncogenic transformation of NIH/3T3 cells by activated neu. J Exp Med (1995) 1.26

Rho and rho kinase modulation of barrier properties: cultured endothelial cells and intact microvessels of rats and mice. J Physiol (2002) 1.26

High-efficiency gene transfer into normal and adenosine deaminase-deficient T lymphocytes is mediated by transduction on recombinant fibronectin fragments. J Virol (1998) 1.25

Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2. Proc Natl Acad Sci U S A (1999) 1.22

A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells. Mol Cell Biol (1995) 1.22

A single point mutation activates the Moloney murine leukemia virus long terminal repeat in embryonal stem cells. J Virol (1991) 1.22

Increased probability of expression from modified retroviral vectors in embryonal stem cells and embryonal carcinoma cells. J Virol (1997) 1.22

Regulation of the resident chromosomal copy of c-myc by c-Myb is involved in myeloid leukemogenesis. Mol Cell Biol (2000) 1.21

High rate of genetic rearrangement during replication of a Moloney murine leukemia virus-based vector. J Virol (1993) 1.21

High-efficiency identification of genes by functional analysis from a retroviral cDNA expression library. J Virol (1994) 1.21

Recombinant adeno-associated virus-mediated high-efficiency, transient expression of the murine cationic amino acid transporter (ecotropic retroviral receptor) permits stable transduction of human HeLa cells by ecotropic retroviral vectors. J Virol (1996) 1.20

Viral vectors for gene delivery to the central nervous system. Neurobiol Dis (2011) 1.20

The role of the membrane-spanning domain sequence in glycoprotein-mediated membrane fusion. Mol Biol Cell (1999) 1.19

Transduction of human embryonic stem cells by ecotropic retroviral vectors. Nucleic Acids Res (2006) 1.19

Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis. J Exp Med (1998) 1.19

Production of high-titer helper virus-free retroviral vectors by cocultivation of packaging cells with different host ranges. J Virol (1991) 1.17

The Moloney murine leukemia virus repressor binding site represses expression in murine and human hematopoietic stem cells. J Virol (2003) 1.17

Development of improved adenosine deaminase retroviral vectors. J Virol (1998) 1.16

A small and efficient dimerization/packaging signal of rat VL30 RNA and its use in murine leukemia virus-VL30-derived vectors for gene transfer. J Virol (1994) 1.16

Articles cited by this

Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65

Colony hybridization: a method for the isolation of cloned DNAs that contain a specific gene. Proc Natl Acad Sci U S A (1975) 77.46

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell (1983) 25.46

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase. Proc Natl Acad Sci U S A (1981) 22.21

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. Proc Natl Acad Sci U S A (1984) 17.51

Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production. Mol Cell Biol (1986) 16.65

Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase. J Virol (1981) 13.11

Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertion. Cell (1981) 8.69

Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors. Nature (1985) 7.54

Generation of helper-free amphotropic retroviruses that transduce a dominant-acting, methotrexate-resistant dihydrofolate reductase gene. Mol Cell Biol (1985) 7.49

Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice. Cell (1985) 6.88

Developmental potential and dynamic behavior of hematopoietic stem cells. Cell (1986) 5.98

High-efficiency gene transfer into mammalian cells: generation of helper-free recombinant retrovirus with broad mammalian host range. Proc Natl Acad Sci U S A (1984) 5.89

Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse. Nature (1984) 5.10

Construction of a helper cell line for avian reticuloendotheliosis virus cloning vectors. Mol Cell Biol (1983) 4.96

Gene expression in mice after high efficiency retroviral-mediated gene transfer. Science (1985) 4.77

Retroviruses as mutagens: insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus. Cell (1981) 4.66

Amphotropic retrovirus vector system for human cell gene transfer. Mol Cell Biol (1984) 4.16

Prospects for human gene therapy. Science (1984) 3.93

Retrovirus-mediated transfer and expression of drug resistance genes in human haematopoietic progenitor cells. Nature (1986) 3.30

Regulated expression of a complete human beta-globin gene encoded by a transmissible retrovirus vector. Mol Cell Biol (1987) 2.77

Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo. Proc Natl Acad Sci U S A (1986) 2.69

Expression of a retrovirus encoding human HPRT in mice. Science (1984) 2.48

Replication-defective chimeric helper proviruses and factors affecting generation of competent virus: expression of Moloney murine leukemia virus structural genes via the metallothionein promoter. Mol Cell Biol (1987) 1.94

Gene transfer in intact animals. Nature (1980) 1.68

Retroviral vector-mediated gene transfer into human hematopoietic progenitor cells. Science (1985) 1.39

Human beta-globin gene expression after gene transfer using retroviral vectors. DNA (1987) 1.19

Articles by these authors

Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase. J Virol (1981) 13.11

A detailed model of reverse transcription and tests of crucial aspects. Cell (1979) 8.93

Structure of a cloned circular Moloney murine leukemia virus DNA molecule containing an inverted segment: implications for retrovirus integration. Proc Natl Acad Sci U S A (1980) 6.73

Changes in restricted human cellular DNA fragments containing globin gene sequences in thalassemias and related disorders. Proc Natl Acad Sci U S A (1978) 6.46

Human immunodeficiency virus type 1 mutants resistant to nonnucleoside inhibitors of reverse transcriptase arise in tissue culture. Proc Natl Acad Sci U S A (1991) 5.83

In vitro synthesis of a 9 kbp terminally redundant DNA carrying the infectivity of Moloney murine leukemia virus. Cell (1979) 5.78

Construction and use of a safe and efficient amphotropic packaging cell line. Virology (1988) 5.58

Organization of human delta--and beta-globin genes in cellular DNA and the presence of intragenic inserts. Cell (1978) 4.18

Intragenic recombination and diversifying selection contribute to the evolution of downy mildew resistance at the RPP8 locus of Arabidopsis. Plant Cell (1998) 3.47

In vitro synthesis of DNA components of human genes for globins. Nat New Biol (1972) 3.23

Rice transposable elements: a survey of 73,000 sequence-tagged-connectors. Genome Res (2000) 2.83

Increased efficiency of exogenous messenger RNA translation in a Krebs ascites cell lysate. Proc Natl Acad Sci U S A (1972) 2.49

Synthesis of a 600-nucleotide-long plus-strand DNA by virions of Moloney murine leukemia virus. Proc Natl Acad Sci U S A (1979) 2.39

The mouse c-abl locus: molecular cloning and characterization. Cell (1984) 2.33

Structure of the Abelson murine leukemia virus genome. Cell (1979) 2.27

A transformation-defective mutant of Abelson murine leukemia virus lacks protein kinase activity. Proc Natl Acad Sci U S A (1980) 2.16

Efficient retrovirus-mediated transfer of the multidrug resistance 1 gene into autologous human long-term repopulating hematopoietic stem cells. Nat Med (2000) 2.09

Decreased globin messenger RNA in thalassemia detected by molecular hybridization. Proc Natl Acad Sci U S A (1973) 2.07

Amputation and adriamycin in primary osteosarcoma. N Engl J Med (1974) 2.04

Erythroid cell differentiation: murine erythroleukemia cell variant with unique pattern of induction by polar compounds. Proc Natl Acad Sci U S A (1976) 1.99

An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells. Mol Cell Biol (2000) 1.97

Relative numbers of human globin genes assayed with purified alpha and beta complementary human DNA. Proc Natl Acad Sci U S A (1975) 1.97

Abnormal or absent beta mRNA in betao Ferrara and gene deletion in delta beta thalassaemia. Nature (1976) 1.96

A nucleotide change at a splice junction in the human beta-globin gene is associated with beta 0-thalassemia. Proc Natl Acad Sci U S A (1981) 1.93

Hemoglobin biosynthesis in murine virus-induced leukemic cells in vitro: structure and amounts of globin chains produced. Blood (1972) 1.81

Treatment of acute myelocytic leukemia: a study by cancer and leukemia group B. Blood (1981) 1.68

Globin composition and synthesis of hemoglobins in developing fetal mice erythroid cells. Science (1967) 1.66

Disorders of human hemoglobin. Science (1980) 1.60

Accumulation of alpha- and beta-globin messenger RNAs in mouse erythroleukemia cells. Cell (1977) 1.54

Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching. Proc Natl Acad Sci U S A (1999) 1.53

The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90. Chem Biol (2000) 1.52

Vagus nerve stimulation and drug reduction. Neurology (2001) 1.45

Cloning and sequence analysis of the putative rifamycin polyketide synthase gene cluster from Amycolatopsis mediterranei. FEMS Microbiol Lett (1998) 1.40

Absolute rates of globin chain synthesis in thalassemia. Blood (1968) 1.40

Reversibility of IVS 2 missplicing in a mutant human beta-globin gene. J Biol Chem (1985) 1.40

Globin messenger RNA activity in erythroid precursor cells and the effect of erythropoietin. Proc Natl Acad Sci U S A (1972) 1.37

Protein synthesis in a cell free human reticulocyte system: ribosome function in thalassemia. J Clin Invest (1966) 1.35

Abnormal splice in a mutant human beta-globin gene not at the site of a mutation. Proc Natl Acad Sci U S A (1983) 1.34

Early stimulation of RNA synthesis by erythropoietin in cultures of erythroid precursor cells. Proc Natl Acad Sci U S A (1973) 1.33

Isolation and characterization of cloned DNA: the delta and beta globin genes in homozygous beta + thalassemia. Blood (1981) 1.33

Changes in globin messenger RNA content during erythroid cell differentiation. J Biol Chem (1975) 1.32

A DNA-binding factor in adult hematopoietic cells interacts with a pyrimidine-rich domain upstream from the human delta-globin gene. Proc Natl Acad Sci U S A (1991) 1.32

Nucleotide sequence analysis of RNA synthesized from rabbit globin complementary DNA. Proc Natl Acad Sci U S A (1974) 1.31

A PAK-like protein kinase is required for maturation of young hyphae and septation in the filamentous ascomycete Ashbya gossypii. J Cell Sci (2000) 1.30

Globin synthesis of intact cells and activity of isolated mRNA in -thalassaemia. Nat New Biol (1973) 1.29

Conservation of globin messenger RNA in rabbit reticulocyte monoribosomes after sodium fluoride treatment. Biochem Biophys Res Commun (1972) 1.27

Heterogeneity of DNA fragments associated with the sickle-globin gene. J Clin Invest (1979) 1.27

Differential effects of chemical inducers on expression of beta globin genes in murine erythroleukemia cells. Proc Natl Acad Sci U S A (1977) 1.25

Polyribosomes and control of protein synthesis: effects of sodium fluoride and temperature of reticulocytes. J Mol Biol (1966) 1.23

A limited number of globin genes in human DNA. Proc Natl Acad Sci U S A (1974) 1.23

Changing rates of globin chain synthesis during erythroid cell maturation in thalassemia. J Mol Biol (1969) 1.21

Human beta-globin gene expression after gene transfer using retroviral vectors. DNA (1987) 1.19

Two cloned beta thalassemia genes are associated with amber mutations at codon 39. Nucleic Acids Res (1981) 1.14

Decreased beta globin mRNA activity in bone marrow cells in homozygous and heterozygous beta thalassaemia. Nat New Biol (1973) 1.12

Epiploic appendicitis: CT characteristics. J Comput Assist Tomogr (1986) 1.12

Polyadenylate sequences and biologic activity of human globin messenger ribonucleic acid. J Biol Chem (1974) 1.11

Decreased globin messenger RNA activity associated with polyribosomes in thalassaemia. Nat New Biol (1973) 1.07

Postsurgical adjuvant chemotherapy of stage II breast carcinoma with or without crossover to a non-cross-resistant regimen: a Cancer and Leukemia Group B study. J Clin Oncol (1996) 1.07

Synthesis of globin mRNA in relation to the cell cycle during induced murine erythroleukemia differentiation. Proc Natl Acad Sci U S A (1978) 1.06

Structure and expression of the Abelson murine leukemia virus genome and its relationship to a normal cell gene. Cold Spring Harb Symp Quant Biol (1980) 1.05

The molecular basis of disorders of human hemoglobin synthesis. Mol Cell Biochem (1980) 1.04

Specific globin mRNAs in human erythroleukemia (K562) cells. Blood (1984) 1.04

Intracellular loss of free alpha chains in beta thalassemia. Nature (1969) 1.03

Sequences in the human immunodeficiency virus type 1 U3 region required for in vivo and in vitro integration. J Virol (1995) 1.02

A new polymorphism in the human beta-globin gene useful in antenatal diagnosis. J Clin Invest (1981) 1.02

Transfer and expression of the human multiple drug resistance gene into live mice. Proc Natl Acad Sci U S A (1992) 1.01

The thalassemia syndromes. Blood (1978) 1.01

Preparative polyacrylamide gel electrophoretic purification of human alpha- and beta-globin messenger RNAs. J Biol Chem (1977) 1.00

Absence of beta mRNA in beta0-thalassemia in Kurdish Jews. Blood (1978) 1.00

Isolation and characterization of cloned human fetal globin genes. Nucleic Acids Res (1979) 0.98

Electrical stimulation for gastroparesis. Gastric motility restored. Surg Endosc (2005) 0.98

Long-term transfer and expression of the human beta-globin gene in a mouse transplant model. Blood (1997) 0.97

Quantitation of human gamma globin genes and gamma globin mRNA with purified gamma globin complementary DNA. J Clin Invest (1976) 0.97

Localization of the site of recombination in formation of the Lepore Boston globin gene. J Clin Invest (1981) 0.97

Erythroleukemia (K562) cells contain a functional beta-globin gene. Mol Cell Biol (1984) 0.97

Tissue specific transcription of the human epsilon-globin gene following transfection into the embryonic erythroid cell line K562. Nucleic Acids Res (1985) 0.96

Lentiviral transduction of green fluorescent protein in retinal epithelium: evidence of rejection. Vision Res (2002) 0.95

DNA sequences regulating human beta globin gene expression. Nucleic Acids Res (1985) 0.95

Stable transfer and expression of exogenous human globin genes in human erythroleukemia (K562) cells. Proc Natl Acad Sci U S A (1984) 0.95

Activation of latent transgenes in Arabidopsis using a hybrid transcription factor. Genetics (1998) 0.95

Phase I trial of retroviral-mediated transfer of the human MDR1 gene as marrow chemoprotection in patients undergoing high-dose chemotherapy and autologous stem-cell transplantation. J Clin Oncol (1998) 0.94

Changes in globin synthesis with erythroid cell maturation in sickle thalassemia. Blood (1973) 0.93

Hemoglobin synthesis in beta-thalassemia: the properties of the free alpha-chains. J Clin Invest (1968) 0.93

Expression of human gamma-globin genes in human erythroleukemia (K562) cells. J Biol Chem (1987) 0.93

Structure of cloned retroviral circular DNAs: implications for virus integration. Cold Spring Harb Symp Quant Biol (1981) 0.93

Defects in DNA and globin messenger RNA in homozygotes for hemoglobin Lepore. J Clin Invest (1979) 0.92

Arterial distensibility and physical activity in the ARIC study. Med Sci Sports Exerc (2001) 0.91

Combination chemotherapy and radiotherapy for acute lymphocytic leukemia in adults: results of CALGB protocol 7113. Leuk Res (1979) 0.91

A novel beta thalassemia gene with a single base mutation in the conserved polypyrimidine sequence at the 3' end of IVS 2. Nucleic Acids Res (1988) 0.91

Retroviral gene transfer using safe and efficient packaging cell lines. Ann N Y Acad Sci (1990) 0.90

Five nucleotide changes in the large intervening sequence of a beta globin gene in a beta+ thalassemia patient. Nucleic Acids Res (1982) 0.90

Frequent and extensive deletion during the 9,22 translocation in CML. Blood (1986) 0.89

Preferential binding of beta s globin chains associated with stroma in sickle cell disorders. J Clin Invest (1974) 0.88

Anticipated reactions to genetic testing for hereditary non-polyposis colorectal cancer susceptibility. Clin Genet (2004) 0.88

Hemoglobin synthesis in thalassemia. Ser Haematol (1971) 0.88

The role of human globin gene promoters in the expression of hybrid genes in erythroid and non-erythroid cells. Biochem Biophys Res Commun (1987) 0.87

Globin chain synthesis in heterozygotes for beta chain mutations. J Lab Clin Med (1970) 0.86