miR-181b regulates vascular stiffness age dependently in part by regulating TGF-β signaling.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28323879)

Published in PLoS One on March 21, 2017

Authors

Daijiro Hori1,2,3, Brittany Dunkerly-Eyring4, Yohei Nomura1,2, Debjit Biswas4, Jochen Steppan2, Jorge Henao-Mejia5, Hideo Adachi3, Lakshmi Santhanam2, Dan E Berkowitz2, Charles Steenbergen4, Richard A Flavell5, Samarjit Das4

Author Affiliations

1: Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
2: Department of Anesthesiology & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America.
3: Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
4: Department of Cardiovascular Pathology, Ross Research Building, Johns Hopkins University, Baltimore, Maryland, United States of America.
5: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, United States of America.

Articles cited by this

Dose translation from animal to human studies revisited. FASEB J (2007) 15.67

Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science (2006) 10.25

Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation (1997) 7.34

Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res (2008) 4.95

Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology (2009) 3.92

Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study. Nat Methods (2014) 2.58

TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene (2009) 2.33

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proc Natl Acad Sci U S A (2011) 2.27

MicroRNA-181b regulates NF-κB-mediated vascular inflammation. J Clin Invest (2012) 2.24

The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis. Immunity (2013) 2.13

Clinical measurement of arterial stiffness obtained from noninvasive pressure waveforms. Am J Hypertens (2005) 2.09

Neutralization of transforming growth factor-beta attenuates hypertension and prevents renal injury in uremic rats. J Hypertens (2005) 2.04

Systemic delivery of microRNA-181b inhibits nuclear factor-κB activation, vascular inflammation, and atherosclerosis in apolipoprotein E-deficient mice. Circ Res (2013) 2.01

Nuclear miRNA regulates the mitochondrial genome in the heart. Circ Res (2012) 1.95

Transforming growth factor-β regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM. Oncogene (2010) 1.92

A simple method of isolating mouse aortic endothelial cells. J Atheroscler Thromb (2005) 1.88

Matrix metalloproteinase 2 activation of transforming growth factor-beta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall. Arterioscler Thromb Vasc Biol (2006) 1.69

Transforming growth factor-beta induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells. Invest Ophthalmol Vis Sci (2011) 1.60

Phosphorylation of endothelial nitric-oxide synthase regulates superoxide generation from the enzyme. J Biol Chem (2008) 1.55

Arterial stiffening with ageing is associated with transforming growth factor-β1-related changes in adventitial collagen: reversal by aerobic exercise. J Physiol (2010) 1.51

Pressure amplification explains why pulse pressure is unrelated to risk in young subjects. Hypertension (2001) 1.47

Measurement of aortic input impedance in mice: effects of age on aortic stiffness. Am J Physiol Heart Circ Physiol (2003) 1.46

Induction of tissue transglutaminase in the trabecular meshwork by TGF-beta1 and TGF-beta2. Invest Ophthalmol Vis Sci (2000) 1.37

Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogen-activated protein kinase. Circ Res (2013) 1.35

Cardiovascular protection by ApoE and ApoE-HDL linked to suppression of ECM gene expression and arterial stiffening. Cell Rep (2012) 1.34

A negative feedback mechanism involving nitric oxide and nuclear factor kappa-B modulates endothelial nitric oxide synthase transcription. J Mol Cell Cardiol (2005) 1.27

Activin and TGFβ regulate expression of the microRNA-181 family to promote cell migration and invasion in breast cancer cells. Cell Signal (2013) 1.22

Microvessel vascular smooth muscle cells contribute to collagen type I deposition through ERK1/2 MAP kinase, alphavbeta3-integrin, and TGF-beta1 in response to ANG II and high glucose. Am J Physiol Heart Circ Physiol (2008) 1.17

Increased aortic stiffness assessed by pulse wave velocity in apolipoprotein E-deficient mice. Am J Physiol Heart Circ Physiol (2000) 1.14

Inhibition of glycosphingolipid synthesis ameliorates atherosclerosis and arterial stiffness in apolipoprotein E-/- mice and rabbits fed a high-fat and -cholesterol diet. Circulation (2014) 1.06

Role of miR-181 family in regulating vascular inflammation and immunity. Trends Cardiovasc Med (2013) 1.06

Integrating the myocardial matrix into heart failure recognition and management. Circ Res (2013) 1.00

Increased tissue transglutaminase activity contributes to central vascular stiffness in eNOS knockout mice. Am J Physiol Heart Circ Physiol (2013) 0.98

MicroRNA-181b inhibits thrombin-mediated endothelial activation and arterial thrombosis by targeting caspase recruitment domain family member 10. FASEB J (2016) 0.95

Exercise, vascular stiffness, and tissue transglutaminase. J Am Heart Assoc (2014) 0.93

Smad2 mediates transforming growth factor-beta induction of endothelial nitric oxide synthase expression. Circ Res (2002) 0.92

LOXL4 is induced by transforming growth factor β1 through Smad and JunB/Fra2 and contributes to vascular matrix remodeling. Mol Cell Biol (2013) 0.91

Coupled and uncoupled NOS: separate but equal? Uncoupled NOS in endothelial cells is a critical pathway for intracellular signaling. Circ Res (2006) 0.91

TGFβ receptor activation enhances cardiac apoptosis via SMAD activation and concomitant NO release. J Cell Physiol (2011) 0.88

Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome. Arterioscler Thromb Vasc Biol (2015) 0.88

Increased aortic stiffness elevates pulse and mean pressure and compromises endothelial function in Wistar rats. Am J Physiol Heart Circ Physiol (2014) 0.88

The epidemiology of blood pressure and its worldwide management. Circ Res (2015) 0.87

Functional role of NF-κB in expression of human endothelial nitric oxide synthase. Biochem Biophys Res Commun (2014) 0.87

Exercise training in hypertension: Role of microRNAs. World J Cardiol (2014) 0.87

Aging impairs smooth muscle-mediated regulation of aortic stiffness: a defect in shock absorption function? Am J Physiol Heart Circ Physiol (2014) 0.86

miR181a protects against angiotensin II-induced osteopontin expression in vascular smooth muscle cells. Atherosclerosis (2013) 0.86

Future Treatment of Hypertension: Shifting the Focus from Blood Pressure Lowering to Arterial Stiffness Modulation? Curr Hypertens Rep (2015) 0.84

MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose Tissue. Circ Res (2016) 0.84

Restoring leptin signaling reduces hyperlipidemia and improves vascular stiffness induced by chronic intermittent hypoxia. Am J Physiol Heart Circ Physiol (2011) 0.83

Modulation of microRNAs in hypertension-induced arterial remodeling through the β1 and β3-adrenoreceptor pathways. J Mol Cell Cardiol (2013) 0.83

Mitochondrial miRNA (MitomiR): a new player in cardiovascular health. Can J Physiol Pharmacol (2015) 0.82

TGF-β Controls miR-181/ERK Regulatory Network during Retinal Axon Specification and Growth. PLoS One (2015) 0.82

Angiotensin II, mechanotransduction, and pulsatile arterial hemodynamics in hypertension. Am J Physiol Heart Circ Physiol (2009) 0.81

Effects of captopril, losartan, and nifedipine on cell hypertrophy of cultured vascular smooth muscle from hypertensive Ren-2 transgenic rats. Br J Pharmacol (1997) 0.81

miR-181 and metabolic regulation in the immune system. Cold Spring Harb Symp Quant Biol (2013) 0.81

Contribution of arginase activation to vascular dysfunction in cigarette smoking. Atherosclerosis (2013) 0.81

Losartan improves measures of activity, inflammation, and oxidative stress in older mice. Exp Gerontol (2014) 0.78

Vascular remodelling and molecular biology: new concepts and therapeutic possibilities. Clin Exp Pharmacol Physiol (1996) 0.78

NEDDylation promotes endothelial dysfunction: a role for HDAC2. J Mol Cell Cardiol (2015) 0.77

Divergent Effects of miR-181 Family Members on Myocardial Function Through Protective Cytosolic and Detrimental Mitochondrial microRNA Targets. J Am Heart Assoc (2017) 0.76

Soluble guanylate cyclase is required for systemic vasodilation but not positive inotropy induced by nitroxyl in the mouse. Hypertension (2014) 0.76

Articles by these authors

Reoperation for enlargement of the distal aorta after initial surgery for acute type A aortic dissection. J Thorac Cardiovasc Surg (2014) 0.95

Solitary intercostal artery aneurysm. Asian Cardiovasc Thorac Ann (2013) 0.80

Blood Pressure Deviations From Optimal Mean Arterial Pressure During Cardiac Surgery Measured With a Novel Monitor of Cerebral Blood Flow and Risk for Perioperative Delirium: A Pilot Study. J Cardiothorac Vasc Anesth (2016) 0.77

Perioperative optimal blood pressure as determined by ultrasound tagged near infrared spectroscopy and its association with postoperative acute kidney injury in cardiac surgery patients. Interact Cardiovasc Thorac Surg (2016) 0.77

Patient-specific assessment of hemodynamics by computational fluid dynamics in patients with bicuspid aortopathy. J Thorac Cardiovasc Surg (2017) 0.77

Efficacy of multiple arterial coronary bypass grafting in patients with diabetes mellitus. Eur J Cardiothorac Surg (2016) 0.76

Effect of carotid revascularization on cerebral autoregulation in combined cardiac surgery†. Eur J Cardiothorac Surg (2015) 0.75

Acute Aortic Dissection Occurring "Behind The Wheel", Report of 11 Cases. Ann Vasc Dis (2016) 0.75

Gene expression profiling of acute type A aortic dissection combined with in vitroassessment†. Eur J Cardiothorac Surg (2017) 0.75

[Diagnosis of thoracic aortic diseases by three-dimensional computed tomography]. Kyobu Geka (2007) 0.75

Pulsatile support using a rotary left ventricular assist device with an electrocardiography-synchronized rotational speed control mode for tracking heart rate variability. J Artif Organs (2015) 0.75

[Informed consent in cardiovascular surgery]. Kyobu Geka (2008) 0.75

Early and mid-term outcomes of endovascular and open surgical repair of non-dissected aortic arch aneurysm†. Interact Cardiovasc Thorac Surg (2017) 0.75