Published in eNeuro on March 29, 2017
Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons. Neuron (2011) 4.88
RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues. J Mol Diagn (2012) 4.63
An endocannabinoid mechanism for stress-induced analgesia. Nature (2005) 4.03
State-dependent opioid control of pain. Nat Rev Neurosci (2004) 3.51
How opioids inhibit GABA-mediated neurotransmission. Nature (1997) 3.09
Descending control of nociception: Specificity, recruitment and plasticity. Brain Res Rev (2008) 2.75
Remote control of neuronal signaling. Pharmacol Rev (2011) 2.66
Endogenous pain control mechanisms: review and hypothesis. Ann Neurol (1978) 2.63
Surgery in the rat during electrical analgesia induced by focal brain stimulation. Science (1969) 2.40
Functional characteristics of the midbrain periaqueductal gray. Prog Neurobiol (1995) 2.35
DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility. Annu Rev Pharmacol Toxicol (2014) 1.99
Chemogenetic tools to interrogate brain functions. Annu Rev Neurosci (2014) 1.92
Pain relief by electrical stimulation of the central gray matter in humans and its reversal by naloxone. Science (1977) 1.62
Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 receptors. J Pharmacol Exp Ther (2005) 1.56
Supraspinal brain-derived neurotrophic factor signaling: a novel mechanism for descending pain facilitation. J Neurosci (2006) 1.45
Pain reduction by focal electrical stimulation of the brain: an anatomical and behavioral analysis. Brain Res (1974) 1.43
Analgesia from electrical stimulation of the periaqueductal gray matter in the cat: behavioral observations and inhibitory effects on spinal cord interneurons. Brain Res (1973) 1.35
Spatiotemporal control of opioid signaling and behavior. Neuron (2015) 1.32
Evidence that an excitatory connection between the periaqueductal gray and nucleus raphe magnus mediates stimulation produced analgesia. Brain Res (1979) 1.22
Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways. J Neurosci (2007) 1.20
Periaqueductal gray neurons project to spinally projecting GABAergic neurons in the rostral ventromedial medulla. Pain (2008) 1.19
Contribution of brainstem GABAergic circuitry to descending antinociceptive controls: I. GABA-immunoreactive projection neurons in the periaqueductal gray and nucleus raphe magnus. J Comp Neurol (1990) 1.14
The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation. J Comp Neurol (1979) 1.13
Evidence for GABA involvement in midbrain control of medullary neurons that modulate nociceptive transmission. Brain Res (1986) 1.11
Lidocaine in the rostroventromedial medulla and the periaqueductal gray attenuates allodynia in neuropathic rats. Neurosci Lett (1996) 1.09
Inflammation-induced shift in the valence of spinal GABA-A receptor-mediated modulation of nociception in the adult rat. J Pain (2008) 1.09
Midbrain circuits for defensive behaviour. Nature (2016) 1.06
Inhibition of spinal nociceptive transmission from the midbrain, pons and medulla in the rat: activation of descending inhibition by morphine, glutamate and electrical stimulation. Brain Res (1988) 1.02
Endogenous opioid peptides acting at mu-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons. J Neurophysiol (1998) 1.00
Columnar organization in the midbrain periaqueductal gray and the integration of emotional expression. Prog Brain Res (1996) 0.99
Capsaicin infused into the PAG affects rat tail flick responses to noxious heat and alters neuronal firing in the RVM. J Neurophysiol (2003) 0.99
The NMDA receptor: central role in pain inhibition in rat periaqueductal gray. Eur J Pharmacol (1988) 0.99
Stimulation of the periaqueductal gray matter inhibits nociception at the supraspinal as well as spinal level. Brain Res (1989) 0.98
Role of the amygdala and periaqueductal gray in anxiety and panic. Behav Brain Res (1993) 0.98
Local opioid withdrawal in rat single periaqueductal gray neurons in vitro. J Neurosci (1996) 0.98
Descending modulation of pain: the GABA disinhibition hypothesis of analgesia. Curr Opin Neurobiol (2014) 0.97
Prostaglandin E2 in the midbrain periaqueductal gray produces hyperalgesia and activates pain-modulating circuitry in the rostral ventromedial medulla. Pain (2004) 0.97
Mu- and delta-opioid receptor mRNAs are expressed in periaqueductal gray neurons projecting to the rostral ventromedial medulla. Neuroscience (2002) 0.95
Autopsy analysis of the safety, efficacy and cartography of electrical stimulation of the central gray in humans. Brain Res (1986) 0.93
The effect of GABA and its antagonists on midbrain periaqueductal gray neurons in the rat. Pain (1990) 0.93
GABAergic modulation of the analgesic effects of morphine microinjected in the ventral periaqueductal gray matter of the rat. Brain Res (1987) 0.92
Descending control of spinal nociception from the periaqueductal grey distinguishes between neurons with and without C-fibre inputs. Pain (2007) 0.92
The periaqueductal gray controls brainstem emotional motor systems including respiration. Prog Brain Res (2014) 0.92
Chronic spinal nerve ligation induces changes in response characteristics of nociceptive spinal dorsal horn neurons and in their descending regulation originating in the periaqueductal gray in the rat. Exp Neurol (1997) 0.91
Inhibitory effects evoked from both the lateral and ventrolateral periaqueductal grey are selective for the nociceptive responses of rat dorsal horn neurones. Brain Res (1997) 0.90
Distribution of messenger RNAs encoding enkephalin, substance P, somatostatin, galanin, vasoactive intestinal polypeptide, neuropeptide Y, and calcitonin gene-related peptide in the midbrain periaqueductal grey in the rat. J Comp Neurol (1994) 0.89
Evidence for two classes of nociceptive modulating neurons in the periaqueductal gray. J Neurosci (1987) 0.89
Blockade of GABAA receptors in the midbrain periaqueductal gray abolishes nociceptive spinal dorsal horn neuronal activity. Eur J Pharmacol (1989) 0.89
Behavioral evidence linking opioid-sensitive GABAergic neurons in the ventrolateral periaqueductal gray to morphine tolerance. Neuroscience (2003) 0.88
Comparison of the antinociceptive effect of morphine and glutamate at coincidental sites in the periaqueductal gray and medial medulla in rats. Brain Res (1989) 0.88
The projections of the midbrain periaqueductal grey to the pons and medulla oblongata in rats. Eur J Neurosci (2001) 0.87
Inhibition of spinal cord interneurons by narcotic microinjection and focal electrical stimulation in the periaqueductal central gray matter. Brain Res (1979) 0.86
The midbrain periaqueductal gray in the rat, cat, and monkey: a Nissl, Weil, and Golgi analysis. J Comp Neurol (1982) 0.86
Periaqueductal grey stimulation: an association between selective inhibition of dorsal horn neurones and changes in peripheral circulation. Pain (1983) 0.85
T-type channels control the opioidergic descending analgesia at the low threshold-spiking GABAergic neurons in the periaqueductal gray. Proc Natl Acad Sci U S A (2010) 0.84
The peptidergic organization of the cat periaqueductal gray. I. The distribution of immunoreactive enkephalin-containing neurons and terminals. J Neurosci (1983) 0.84
Localization of the antinociceptive and antianalgesic effects of neurotensin within the rostral ventromedial medulla. Neurosci Lett (1994) 0.83
Hypofunction of glutamatergic neurotransmission in the periaqueductal gray contributes to nerve-injury-induced neuropathic pain. J Neurosci (2013) 0.82
Suppression of nociceptive responses in the primate by electrical stimulation of the brain or morphine administration: behavioral and electrophysiological comparisons. Brain Res (1979) 0.82
The peptidergic organization of the cat periaqueductal gray. II. The distribution of immunoreactive substance P and vasoactive intestinal polypeptide. J Neurosci (1983) 0.82
GABAergic synaptic response and its opioidergic modulation in periaqueductal gray neurons of rats with neuropathic pain. BMC Neurosci (2011) 0.82
The periaqueductal gray projections to the rat spinal trigeminal, raphe magnus, gigantocellular pars alpha and paragigantocellular nuclei arise from separate neurons. Brain Res (1983) 0.81
Quantitative comparison of inhibition of visceral and cutaneous spinal nociceptive transmission from the midbrain and medulla in the rat. J Neurophysiol (1987) 0.81
The neural basis of footshock analgesia: the role of specific ventral medullary nuclei. Brain Res (1983) 0.81
Brain sources of inhibitory input to the rat rostral ventrolateral medulla. J Comp Neurol (2013) 0.81
Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1. J Pain (2013) 0.81
Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes. Nat Neurosci (2016) 0.81
Microinjections of glutamate or morphine at coincident midbrain sites have different effects on nociceptive dorsal horn neurons in the rat. Neurosci Lett (1988) 0.79
Suppression of a hind limb flexion withdrawal reflex by microinjection of glutamate or morphine into the periaqueductal gray in the rat. Pain (1990) 0.78
Activation of periaqueductal grey pools of beta-endorphin by analgetic electrical stimulation in freely moving rats. Brain Res (1987) 0.77
Post-ictal analgesia in genetically epilepsy-prone rats is induced by audiogenic seizures and involves cannabinoid receptors in the periaqueductal gray. Brain Res (2011) 0.77
The effects of lesions of medullary midline and lateral reticular areas on inhibition in the dorsal horn produced by periaqueductal grey stimulation in the cat. Brain Res (1984) 0.76
NMDA receptor blockade in the periaqueductal grey prevents stress-induced analgesia in attacked mice. Eur J Pharmacol (1989) 0.76
Endogenous opioids acting at a medullary mu-opioid receptor contribute to the behavioral antinociception produced by GABA antagonism in the midbrain periaqueductal gray. Neuroscience (1996) 0.76
Neural Correlates of Fear in the Periaqueductal Gray. J Neurosci (2016) 0.76