Published in Wellcome Open Res on March 17, 2017
Magnesium gates glutamate-activated channels in mouse central neurones. Nature (1984) 13.67
Analysis of protein-coding genetic variation in 60,706 humans. Nature (2016) 11.83
Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron (1994) 11.44
Diagnostic exome sequencing in persons with severe intellectual disability. N Engl J Med (2012) 10.80
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature (1984) 9.22
Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature (1987) 8.89
Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science (1992) 6.49
NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature (1986) 4.88
NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease. Nat Rev Neurosci (2013) 4.35
The UK10K project identifies rare variants in health and disease. Nature (2015) 3.89
Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes. Nat Genet (2010) 3.82
Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science (1993) 3.71
Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol Pharmacol (1993) 3.63
Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition. Nat Neurosci (1998) 2.21
Developmental changes in distribution of NMDA receptor channel subunit mRNAs. Neuroreport (1992) 2.11
GRIN2A mutations cause epilepsy-aphasia spectrum disorders. Nat Genet (2013) 1.85
Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes. Nat Genet (2013) 1.59
Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains. Am J Hum Genet (2016) 1.54
NMDA receptor subunit mutations in neurodevelopmental disorders. Curr Opin Pharmacol (2014) 1.08
Influence of GluN2 subunit identity on NMDA receptor function. Neuropharmacology (2013) 1.07
Expression of NMDA receptor NR1, NR2A and NR2B subunit mRNAs during development of the human hippocampal formation. Eur J Neurosci (2003) 1.06
Seizure-like activity and cellular damage in rat hippocampal neurons in cell culture. Neuron (1989) 1.03
Molecular pharmacology of human NMDA receptors. Neurochem Int (2011) 0.96
Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist. Br J Pharmacol (2012) 0.89
Altered zinc sensitivity of NMDA receptors harboring clinically-relevant mutations. Neuropharmacology (2016) 0.86
Mutation screening of GRIN2B in schizophrenia and autism spectrum disorder in a Japanese population. Sci Rep (2016) 0.77