Adoptive natural killer cell therapy is effective in reducing pulmonary metastasis of Ewing sarcoma.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28507811)

Published in Oncoimmunology on March 16, 2017

Authors

Alexander A Tong1, Hasan Hashem2, Saada Eid2, Frederick Allen1, Daniel Kingsley2, Alex Y Huang1,2,3,4

Author Affiliations

1: Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
2: Division of Pediatric Hematology-Oncology, Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
3: Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
4: Angie Fowler AYA Cancer Institute, University Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA.

Articles cited by this

Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med (2003) 8.48

The Ewing family of tumors--a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl J Med (1994) 4.65

Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group. J Clin Oncol (2000) 4.15

Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group. J Clin Oncol (2012) 2.96

Cytotoxicity of activated natural killer cells against pediatric solid tumors. Clin Cancer Res (2010) 2.51

NK cell-based immunotherapy for malignant diseases. Cell Mol Immunol (2013) 2.39

Membrane-bound IL-21 promotes sustained ex vivo proliferation of human natural killer cells. PLoS One (2012) 2.09

Cytogenetic characterization of selected small round cell tumors of childhood. Cancer Genet Cytogenet (1986) 2.04

Complexities of TGF-β targeted cancer therapy. Int J Biol Sci (2012) 1.84

Natural killer cell-based immunotherapy in cancer: current insights and future prospects. J Intern Med (2009) 1.51

Evidence for NK cell subsets based on chemokine receptor expression. J Immunol (2006) 1.39

Expansion, purification, and functional assessment of human peripheral blood NK cells. J Vis Exp (2011) 1.32

NK cells recognize and lyse Ewing sarcoma cells through NKG2D and DNAM-1 receptor dependent pathways. Mol Immunol (2008) 1.23

Reduced human leukocyte antigen expression in advanced-stage Ewing sarcoma: implications for immune recognition. J Pathol (2009) 1.09

Prognostic factors for local and distant control in Ewing sarcoma family of tumors. Ann Oncol (2007) 1.08

Infusions of allogeneic natural killer cells as cancer therapy. Clin Cancer Res (2014) 1.05

Human natural killer cells: origin, receptors, function, and clinical applications. Int Arch Allergy Immunol (2014) 1.03

Expansion and activation of natural killer cells for cancer immunotherapy. Korean J Lab Med (2009) 1.02

TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway. Sci Signal (2016) 0.97

Autonomous growth and increased cytotoxicity of natural killer cells expressing membrane-bound interleukin-15. Blood (2014) 0.92

Natural killer cell therapy and aerosol interleukin-2 for the treatment of osteosarcoma lung metastasis. Pediatr Blood Cancer (2013) 0.90

Immune reconstitution prevents metastatic recurrence of murine osteosarcoma. Cancer Immunol Immunother (2006) 0.90

CXCL10-induced migration of adoptively transferred human natural killer cells toward solid tumors causes regression of tumor growth in vivo. Cancer Immunol Immunother (2014) 0.90

Functional and molecular characterization of interleukin-2 transgenic Ewing tumor cells for in vivo immunotherapy. Pediatr Blood Cancer (2004) 0.89

Activated and expanded natural killer cells target osteosarcoma tumor initiating cells in an NKG2D-NKG2DL dependent manner. Cancer Lett (2015) 0.87

Natural Killer Cell Immunomodulation: Targeting Activating, Inhibitory, and Co-stimulatory Receptor Signaling for Cancer Immunotherapy. Front Immunol (2015) 0.85

Challenges of cancer therapy with natural killer cells. Cytotherapy (2014) 0.84

Ewing's sarcoma: ex vivo sensitivity towards natural and lymphokine-activated killing. Oncology (1988) 0.84

Lymphokine-activated killer cytotoxicity in neonatal mononuclear cells: in vitro responses to tumor cell lines from pediatric solid tumors. Pediatr Res (1989) 0.84

Killing the killer: natural killer cells to treat Ewing's sarcoma. Clin Cancer Res (2010) 0.83

Going back to class I: MHC and immunotherapies for childhood cancer. Pediatr Blood Cancer (2014) 0.80

Natural killer cells: biology, physiology and medicine--part 1. J Innate Immun (2011) 0.79

Mechanistic model of natural killer cell proliferative response to IL-15 receptor stimulation. PLoS Comput Biol (2013) 0.78

Cellular immunotherapy strategies for Ewing sarcoma. Immunotherapy (2014) 0.78

Natural killer cell receptors: alterations and therapeutic targeting in malignancies. Immunol Res (2016) 0.78

Natural killer cells inhibit pulmonary metastasis of hepatocellular carcinoma in nude mice. Oncol Lett (2016) 0.77