The J-shaped Curve for Blood Pressure and Cardiovascular Disease Risk: Historical Context and Recent Updates.

Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet (2002) 40.37

2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA (2014) 34.12

Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet (1998) 26.64

Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med (2010) 21.49

Treatment of hypertension in patients 80 years of age or older. N Engl J Med (2008) 21.04

A Randomized Trial of Intensive versus Standard Blood-Pressure Control. N Engl J Med (2015) 19.14

Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. JAMA (1991) 14.36

Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet (1997) 9.18

Mortality and morbidity results from the European Working Party on High Blood Pressure in the Elderly trial. Lancet (1985) 8.35

Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Research Group. JAMA (2000) 7.73

Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg. JAMA (1970) 6.73

Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data. Lancet (2014) 6.23

Five-year findings of the hypertension detection and follow-up program. I. Reduction in mortality of persons with high blood pressure, including mild hypertension. Hypertension Detection and Follow-up Program Cooperative Group. JAMA (1979) 5.72

Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease. N Engl J Med (2016) 5.72

Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial. JAMA (2016) 5.67

A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial. JAMA (2003) 5.67

Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. JAMA (1967) 5.54

Dogma disputed: can aggressively lowering blood pressure in hypertensive patients with coronary artery disease be dangerous? Ann Intern Med (2006) 5.18

Tight blood pressure control and cardiovascular outcomes among hypertensive patients with diabetes and coronary artery disease. JAMA (2010) 5.06

MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party. Br Med J (Clin Res Ed) (1985) 4.98

Benefits and potential harm of lowering high blood pressure. Lancet (1987) 4.88

A longitudinal study of coronary heart disease. Circulation (1963) 4.30

Coronary heart disease in the Framingham study. Am J Public Health Nations Health (1957) 4.13

Incidence and prediction of ischaemic heart-disease in London busmen. Lancet (1966) 3.91

Effects of intensive blood pressure reduction on myocardial infarction and stroke in diabetes: a meta-analysis in 73,913 patients. J Hypertens (2011) 3.50

Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension (2010) 3.00

Executive Summary: Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation (2016) 2.87

The Australian therapeutic trial in mild hypertension. Report by the Management Committee. Lancet (1980) 2.81

Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. Circulation (2017) 2.76

The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective. Lancet (2013) 2.74

The J-curve phenomenon and the treatment of hypertension. Is there a point beyond which pressure reduction is dangerous? JAMA (1991) 2.68

Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials. Lancet (2017) 2.65

Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. A cooperative study. JAMA (1977) 2.60

A likely explanation for the J-curve of blood pressure cardiovascular risk. Am J Cardiol (2004) 2.36

An effective approach to high blood pressure control: a science advisory from the American Heart Association, the American College of Cardiology, and the Centers for Disease Control and Prevention. Hypertension (2013) 1.95

Screening for High Blood Pressure in Adults: U.S. Preventive Services Task Force Recommendation Statement. Ann Intern Med (2015) 1.94

Upward shift of the lower range of coronary flow autoregulation in hypertensive patients with hypertrophy of the left ventricle. Circulation (1991) 1.89

Blood pressure targets recommended by guidelines and incidence of cardiovascular and renal events in the Ongoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial (ONTARGET). Circulation (2011) 1.77

Long-term observations on high blood-pressure presenting in fit young men. Lancet (1971) 1.71

The J-curve between blood pressure and coronary artery disease or essential hypertension: exactly how essential? J Am Coll Cardiol (2009) 1.67

Cardiovascular event rates and mortality according to achieved systolic and diastolic blood pressure in patients with stable coronary artery disease: an international cohort study. Lancet (2016) 1.59

Treatment of hypertension in patients with coronary artery disease: A scientific statement from the American Heart Association, American College of Cardiology, and American Society of Hypertension. J Am Soc Hypertens (2015) 1.45

Relation of low diastolic blood pressure to coronary heart disease death in presence of myocardial infarction: the Framingham Study. BMJ (1991) 1.44

Pulse Pressure and Risk for Cardiovascular Events in Patients With Atherothrombosis: From the REACH Registry. J Am Coll Cardiol (2016) 1.41

Level of systolic blood pressure within the normal range and risk of recurrent stroke. JAMA (2011) 1.40

Re-examination of some of the Framingham blood-pressure data. Lancet (1978) 1.13

Hypertension and Its Relationship to the Functional Activities of the Vessels. Can Med Assoc J (1924) 1.07

Blood pressure and mortality in elderly people aged 85 and older: community based study. BMJ (1998) 1.04

New prospects in the treatment of hypertension. Lancet (1957) 1.02

The 1980 report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure. Arch Intern Med (1980) 0.99

Antihypertensive treatment and the J-curve. Cardiovasc Drugs Ther (2000) 0.84

CDC Grand Rounds: A Public Health Approach to Detect and Control Hypertension. MMWR Morb Mortal Wkly Rep (2016) 0.84

Myocardial perfusion pressure in patients with hypertension and coronary artery disease: implications for DBP targets in hypertension management. J Hypertens (2013) 0.84

Arterial stiffness and coronary artery disease. Curr Opin Cardiol (2015) 0.83

High-sensitivity troponin T and cardiovascular events in systolic blood pressure categories: atherosclerosis risk in communities study. Hypertension (2014) 0.83

Change in blood pressure and 5-year risk of coronary heart disease among elderly men: the Finnish cohorts of the Seven Countries Study. J Hypertens (1994) 0.82

US Hypertension Management Guidelines: A Review of the Recent Past and Recommendations for the Future. J Am Heart Assoc (2015) 0.82

Diastolic Blood Pressure, Subclinical Myocardial Damage, and Cardiac Events: Implications for Blood Pressure Control. J Am Coll Cardiol (2016) 0.80

Coronary Artery Calcium to Guide a Personalized Risk-Based Approach to Initiation and Intensification of Antihypertensive Therapy. Circulation (2016) 0.80

The coronary artery disease paradox. Am J Hypertens (1996) 0.76

Lessons learned from Systolic Blood Pressure Intervention Trial. Curr Opin Cardiol (2017) 0.76

Troponin and the J-Curve of Diastolic Blood Pressure: When Lower Is Not Better. J Am Coll Cardiol (2016) 0.76

The Significance, Treatment, and Prognosis of High Blood-pressure. Proc R Soc Med (1913) 0.75